Engineering antibody fragments: replicating the immune system and beyond - La ingeniería de fragmentos de anticuerpos: imitando y expandiendo el sistema inmune
.
Since genetic engineering of humanized murine monoclonal antibodies was first demonstrated over two decades ago, antibody engineering technologies have evolved based upon an increasing understanding of the mechanisms involved in antibody generation in vivo, and a constant search for alternative routes to evolve and exploit the characteristics of antibodies. As a result, antibody engineers have devised innovative strategies for the rapid evolution and selection of antibodies and novel antibody designs (i.e., antibody fragments). Phage display, cell display and ribosome display technologies, which comprise the core of the currently available technologies for the discovery and preparation of such antibodies, are reviewed herein. This article i... Ver más
1909-9762
1909-9991
4
2011-11-22
39
51
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
