Parametric analysis of drug distribution during infusions into the brain using an axisymmetric model with backflow
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Abstract ─ Convection-enhanced delivery as a means to deliver therapeutic drugs directly to the brain has shown limited clinical efficacy, primarily attributed to the phenomena of backflow, in which the infused fluid flows preferentially along the shaft catheter rather than forward into the tissue. We have previously developed a finite element model of backflow that includes both material and geometric nonlinearities and the free boundary conditions associated with the displacement of the tissue away from the external surface of the catheter. However, that study was limited to predictions of the tissue deformation and resulting convective fluid velocity in the interstitial space. In this study, we use results from that model to solve for th... Ver más
1909-9762
1909-9991
8
2015-12-30
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
