Titulo:
Evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana
.
Sumario:
La endometritis bacteriana es una de las causas más comunes de falla reproductiva en yeguas, generalmente asociada a agentes bacterianos como Streptococcus equi, Echerichia coli, Enterococcus spp, Klebsiella sp., entre otros. De manera común se utilizan terapias antimicrobianas a base de fármacos betalactámicos y aminoglucósidos infiltrados a nivel uterino o en terapia sistémica. Para el presente estudio se tiene como objetivo principal evaluar la eficacia clínica de tres protocolos antibióticos en yeguas con diagnóstico de endometritis bacteriana y verificar su desempeño reproductivo postratamiento. La muestra se realizó con 90 yeguas diagnosticadas con infección uterina. Mediante examen clínico reproductivo, vaginoscopia y ecografía. Se t... Ver más
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Evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana Evaluation of the clinical efficacy of three antibiotic protocols in mares diagnosed with bacterial endometritis La endometritis bacteriana es una de las causas más comunes de falla reproductiva en yeguas, generalmente asociada a agentes bacterianos como Streptococcus equi, Echerichia coli, Enterococcus spp, Klebsiella sp., entre otros. De manera común se utilizan terapias antimicrobianas a base de fármacos betalactámicos y aminoglucósidos infiltrados a nivel uterino o en terapia sistémica. Para el presente estudio se tiene como objetivo principal evaluar la eficacia clínica de tres protocolos antibióticos en yeguas con diagnóstico de endometritis bacteriana y verificar su desempeño reproductivo postratamiento. La muestra se realizó con 90 yeguas diagnosticadas con infección uterina. Mediante examen clínico reproductivo, vaginoscopia y ecografía. Se tomaron muestras de cultivo uterino por medio de hisopado, a su vez se realizó antibiograma. Las yeguas fueron divididas en tres grupos de tratamiento antibiótico asignados según el resultado del antibiograma: penicilina G procaínica (n=4), ceftiofur (n=10) y gentamicina (n=20). Posteriormente se evaluó la eficacia clínica y el desempeño reproductivo de las yeguas. De las tratadas con penicilina, 75% (3/4) se recuperaron y dos quedaron gestantes; de las tratadas con gentamicina, 75% (15/20) se recuperaron y 8 quedaron gestantes; en tanto que de las tratadas con ceftiofur, 70% (7/10) se recuperaron y a 5 se le confirmó gestación. Se concluye no hubo diferencias clínicas o reproductivas postratamiento por efecto del tipo de antibiótico empleado. Bacterial endometritis is one of the most common causes of reproductive failure in mares, generally associated with bacterial agents such as Streptococcus equi, Echerichia coli, Enterococcus spp, Klebsiella sp., Among others. Antimicrobial therapies based on beta-lactam drugs and aminoglycosides infiltrated at the uterine level or in systemic therapy are commonly used. The main objective of this study is to evaluate the clinical efficacy of three antibiotic protocols in mares with a diagnosis of bacterial endometritis and to verify their post-treatment reproductive performance. The sample was made with 90 mares diagnosed with uterine infection. By reproductive clinical examination, vaginoscopy and ultrasound. Uterine culture samples were taken by means of swabbing, in turn an antibiogram was performed. The mares were divided into three antibiotic treatment groups assigned according to the antibiogram results: procaine penicillin G (n = 4), ceftiofur (n = 10) and gentamicin (n = 20). Subsequently, the clinical efficacy and reproductive performance of the mares were evaluated. Of those treated with penicillin, 75% (3/4) recovered and two became pregnant; of those treated with gentamicin, 75% (15/20) recovered and 8 became pregnant; while of those treated with ceftiofur, 70% (7/10) recovered and 5 had pregnancy confirmed. It is concluded there were no post-treatment clinical or reproductive differences due to the type of antibiotic used. Gallego Rodríguez, Renso Sneider Ruíz-Jaramillo, Andrés Felipe Ruíz-Buitrago, Jhon Didier Antibiotics diagnostics endometritis fertility mare reproduction Antibióticos diagnóstico endometritis fertilidad reproducción yegua 13 1 Núm. 1 , Año 2021 : RECIA 13(1):ENERO-JUNIO 2021 Artículo de revista Journal article 2020-11-11T00:00:00Z 2020-11-11T00:00:00Z 2020-11-11 application/pdf Universidad de Sucre Revista Colombiana de Ciencia Animal - RECIA 2027-4297 https://revistas.unisucre.edu.co/index.php/recia/article/view/e772 10.24188/recia.v13.n1.2021.772 https://doi.org/10.24188/recia.v13.n1.2021.772 spa https://creativecommons.org/licenses/by-nc-sa/4.0/ Revista Colombiana de Ciencia Animal - RECIA - 2021 e772 e772 Causey RC. Making Sense of Equine Uterine Infections: The Many Faces of Physical Clearance. Vet J. 2006; 172(3):405–421. https://doi.org/10.1016/j.tvjl.2005.08.005 Leblanc MM, Causey RC. Clinical and Subclinical Endometritis in the Mare: Both Threats to Fertility. Reprod Domest Anim. 2009; 44(S3):10–22. https://doi.org/10.2746/095777308X357621 Riddle WT, LeBlanc MM, Stromberg AJ. Relationships between Uterine Culture, Cytology and Pregnancy Rates in a Thoroughbred Practice. Theriogenology. 2007; 68(3):395–402. https://doi.org/10.1016/j.theriogenology.2007.05.050 Overbeck W, Witte TS, Heuwieser W. Comparison of Three Diagnostic Methods to Identify Subclinical Endometritis in Mares. Theriogenology. 2011; 75(7):1311–18. https://doi.org/10.1016/j.theriogenology.2010.12.002 Hurtgen JP. Pathogenesis and Treatment of Endometritis in the Mare: A Review. Theriogenology. 2006; 66(3 SPEC. ISS.): 560–566. https://doi.org/10.1016/j.theriogenology.2006.04.006 Ferris RA. Therapeutics for Infectious Endometritis: A Clinical Perspective. Rev Bras. Reprod Anim. 2017; 41(1):175–179. http://cbra.org.br/portal/downloads/publicacoes/rbra/v41/n1/p175-179%20(RB634).pdf Buczkowska J, Kozdrowski R, Sikora M, Dzieciol M, Matusz A. Non Traditional Treatments for Endometritis in Mares. Bulgarian Journal of Veterinary Medicine. 2015; 18(4):285-293 https://doi.org/10.15547/bjvm.870 Morales PC, Castro RA. Estimación de La Integridad Uterina En Yeguas Pura Raza Chilena y Su Asociación Con Edad y Número de Partos. Revista de Investigaciones Veterinarias del Perú. 2018 29(2): 565. https://doi.org/10.15381/rivep.v29i2.14489 Liu IK, Troedsson MH. The Diagnosis and Treatment of Endometritis in the Mare: Yesterday and Today. Theriogenology. 2008. 70(3):415–20. https://doi.org/10.1016/j.theriogenology.2008.05.040 LeBlanc MM. Advances in the Diagnosis and Treatment of Chronic Infectious and Post-Mating-Induced Endometritis in the Mare. Reproduction in Domestic Animals. 2010 45(Suppl. 2):21–27. https://doi.org/10.1111/j.1439-0531.2010.01634.x Cervantes CC, Brown MP, Gronwall R, and Merritt K. 1993. Pharmacokinetics and Concentrations of Ceftiofur Sodium in Body Fluids and Endometrium after Repeated Intramuscular Injections in Mares. Am J Vet Res. 1993. 54:573–575. https://pubmed.ncbi.nlm.nih.gov/8484577/ Jonker FH. Secretion of Ceftiofur in Equine Endometrium after Parenteral Administration. Vet Pharmacol Therap. 1997. 20:(Suppl):37. http://agris.fao.org/agris-search/search.do?recordID=GB1997026008 Nash D, Lane E, Herath S, Sheldon M. Endometrial Explant Culture for Characterizing Equine Endometritis. Am J Reprod Immunol. 2008 59(2):105–117. https://doi.org/10.1111/j.1600-0897.2007.00548.x Collard WT, Cox SR., Lesman SP, Grover GS, Boucher JF, Hallberg JW, and Robinson SA and Brown JA. Pharmacokinetics of Ceftiofur Crystalline-Free Acid Sterile Suspension in the Equine. Vet Pharmacol. 2011. 34(5):476–481. https://doi.org/10.1111/j.1365-2885.2011.01266.x Scofield D, Black J, Wittenburg L, Gustafson D, Ferris R, Hatzel J, Traub - Dargatz J, McCue P. Endometrial Tissue and Blood Plasma Concentration of Ceftiofur and Metabolites Following Intramuscular Administration of Ceftiofur Crystalline Free Acid to Mares. Equine Veterinary Journal. 2014. 46(5):606–610. https://doi.org/10.1111/evj.12192 Canisso IF, Coutinho DS. Bacterial Endometritis. Robinson’s Current Therapy in Equine Medicine. Saunders, Elsevier; 2015. https://doi.org/10.1016/B978-1-4557-4555-5.00163-1 Gores-Lindholm, Alicia R. et al. Relationships between Intrauterine Infusion of N-Acetylcysteine, Equine Endometrial Pathology, Neutrophil Function, Post-Breeding Therapy, and Reproductive Performance. Theriogenology. 2013 80(3):218–227. http://dx.doi.org/10.1016/j.theriogenology.2013.03.026 Sosa AM, Mahmoud EA. Ultrasonographic, Cytological and Bacteriological Investigation of Endometritis in Arabian Mares. Global Veterinaria. 15(3):296-303. https://www.idosi.org/gv/gv15(3)15/6.pdf Rodriguez JS, et al. Consequences of Intrauterine Enrofloxacin Infusion on Mare Endometrium. Journal of Equine Veterinary Science. 2012; 32(2):106–111. http://dx.doi.org/10.1016/j.jevs.2011.08.003 Pedersoli WM, Fazeli MH, Haddad NS, Ravis WR, Carson RL. Eudometrial AmY Serum Gentamicin Conwn-Tration in Pony .Xares given Repeated Intrauterine Infusion. Am J Vet Res. 1985; 46(5):1025-1028. https://www.ncbi.nlm.nih.gov/pubmed/4003879 Linton JK, Sertich PL. The Impact of Low-Volume Uterine Lavage on Endometrial Biopsy Classification. Theriogenology. 2016; 86(4):1004–1007. http://dx.doi.org/10.1016/j.theriogenology.2016.03.028 https://revistas.unisucre.edu.co/index.php/recia/article/download/e772/945 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/redcol/resource_type/ARTREF info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication |
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UNIVERSIDAD DE SUCRE |
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Colombia |
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Revista Colombiana de Ciencia Animal - RECIA |
| title |
Evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana |
| spellingShingle |
Evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana Gallego Rodríguez, Renso Sneider Ruíz-Jaramillo, Andrés Felipe Ruíz-Buitrago, Jhon Didier Antibiotics diagnostics endometritis fertility mare reproduction Antibióticos diagnóstico endometritis fertilidad reproducción yegua |
| title_short |
Evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana |
| title_full |
Evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana |
| title_fullStr |
Evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana |
| title_full_unstemmed |
Evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana |
| title_sort |
evaluación de la eficacia clínica de tres protocolos antibióticos en yeguas diagnosticadas con endometritis bacteriana |
| title_eng |
Evaluation of the clinical efficacy of three antibiotic protocols in mares diagnosed with bacterial endometritis |
| description |
La endometritis bacteriana es una de las causas más comunes de falla reproductiva en yeguas, generalmente asociada a agentes bacterianos como Streptococcus equi, Echerichia coli, Enterococcus spp, Klebsiella sp., entre otros. De manera común se utilizan terapias antimicrobianas a base de fármacos betalactámicos y aminoglucósidos infiltrados a nivel uterino o en terapia sistémica. Para el presente estudio se tiene como objetivo principal evaluar la eficacia clínica de tres protocolos antibióticos en yeguas con diagnóstico de endometritis bacteriana y verificar su desempeño reproductivo postratamiento. La muestra se realizó con 90 yeguas diagnosticadas con infección uterina. Mediante examen clínico reproductivo, vaginoscopia y ecografía. Se tomaron muestras de cultivo uterino por medio de hisopado, a su vez se realizó antibiograma. Las yeguas fueron divididas en tres grupos de tratamiento antibiótico asignados según el resultado del antibiograma: penicilina G procaínica (n=4), ceftiofur (n=10) y gentamicina (n=20). Posteriormente se evaluó la eficacia clínica y el desempeño reproductivo de las yeguas. De las tratadas con penicilina, 75% (3/4) se recuperaron y dos quedaron gestantes; de las tratadas con gentamicina, 75% (15/20) se recuperaron y 8 quedaron gestantes; en tanto que de las tratadas con ceftiofur, 70% (7/10) se recuperaron y a 5 se le confirmó gestación. Se concluye no hubo diferencias clínicas o reproductivas postratamiento por efecto del tipo de antibiótico empleado.
|
| description_eng |
Bacterial endometritis is one of the most common causes of reproductive failure in mares, generally associated with bacterial agents such as Streptococcus equi, Echerichia coli, Enterococcus spp, Klebsiella sp., Among others. Antimicrobial therapies based on beta-lactam drugs and aminoglycosides infiltrated at the uterine level or in systemic therapy are commonly used. The main objective of this study is to evaluate the clinical efficacy of three antibiotic protocols in mares with a diagnosis of bacterial endometritis and to verify their post-treatment reproductive performance. The sample was made with 90 mares diagnosed with uterine infection. By reproductive clinical examination, vaginoscopy and ultrasound. Uterine culture samples were taken by means of swabbing, in turn an antibiogram was performed. The mares were divided into three antibiotic treatment groups assigned according to the antibiogram results: procaine penicillin G (n = 4), ceftiofur (n = 10) and gentamicin (n = 20). Subsequently, the clinical efficacy and reproductive performance of the mares were evaluated. Of those treated with penicillin, 75% (3/4) recovered and two became pregnant; of those treated with gentamicin, 75% (15/20) recovered and 8 became pregnant; while of those treated with ceftiofur, 70% (7/10) recovered and 5 had pregnancy confirmed. It is concluded there were no post-treatment clinical or reproductive differences due to the type of antibiotic used.
|
| author |
Gallego Rodríguez, Renso Sneider Ruíz-Jaramillo, Andrés Felipe Ruíz-Buitrago, Jhon Didier |
| author_facet |
Gallego Rodríguez, Renso Sneider Ruíz-Jaramillo, Andrés Felipe Ruíz-Buitrago, Jhon Didier |
| topic |
Antibiotics diagnostics endometritis fertility mare reproduction Antibióticos diagnóstico endometritis fertilidad reproducción yegua |
| topic_facet |
Antibiotics diagnostics endometritis fertility mare reproduction Antibióticos diagnóstico endometritis fertilidad reproducción yegua |
| topicspa_str_mv |
Antibióticos diagnóstico endometritis fertilidad reproducción yegua |
| citationvolume |
13 |
| citationissue |
1 |
| citationedition |
Núm. 1 , Año 2021 : RECIA 13(1):ENERO-JUNIO 2021 |
| publisher |
Universidad de Sucre |
| ispartofjournal |
Revista Colombiana de Ciencia Animal - RECIA |
| source |
https://revistas.unisucre.edu.co/index.php/recia/article/view/e772 |
| language |
spa |
| format |
Article |
| rights |
https://creativecommons.org/licenses/by-nc-sa/4.0/ Revista Colombiana de Ciencia Animal - RECIA - 2021 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
| references |
Causey RC. Making Sense of Equine Uterine Infections: The Many Faces of Physical Clearance. Vet J. 2006; 172(3):405–421. https://doi.org/10.1016/j.tvjl.2005.08.005 Leblanc MM, Causey RC. Clinical and Subclinical Endometritis in the Mare: Both Threats to Fertility. Reprod Domest Anim. 2009; 44(S3):10–22. https://doi.org/10.2746/095777308X357621 Riddle WT, LeBlanc MM, Stromberg AJ. Relationships between Uterine Culture, Cytology and Pregnancy Rates in a Thoroughbred Practice. Theriogenology. 2007; 68(3):395–402. https://doi.org/10.1016/j.theriogenology.2007.05.050 Overbeck W, Witte TS, Heuwieser W. Comparison of Three Diagnostic Methods to Identify Subclinical Endometritis in Mares. Theriogenology. 2011; 75(7):1311–18. https://doi.org/10.1016/j.theriogenology.2010.12.002 Hurtgen JP. Pathogenesis and Treatment of Endometritis in the Mare: A Review. Theriogenology. 2006; 66(3 SPEC. ISS.): 560–566. https://doi.org/10.1016/j.theriogenology.2006.04.006 Ferris RA. Therapeutics for Infectious Endometritis: A Clinical Perspective. Rev Bras. Reprod Anim. 2017; 41(1):175–179. http://cbra.org.br/portal/downloads/publicacoes/rbra/v41/n1/p175-179%20(RB634).pdf Buczkowska J, Kozdrowski R, Sikora M, Dzieciol M, Matusz A. Non Traditional Treatments for Endometritis in Mares. Bulgarian Journal of Veterinary Medicine. 2015; 18(4):285-293 https://doi.org/10.15547/bjvm.870 Morales PC, Castro RA. Estimación de La Integridad Uterina En Yeguas Pura Raza Chilena y Su Asociación Con Edad y Número de Partos. Revista de Investigaciones Veterinarias del Perú. 2018 29(2): 565. https://doi.org/10.15381/rivep.v29i2.14489 Liu IK, Troedsson MH. The Diagnosis and Treatment of Endometritis in the Mare: Yesterday and Today. Theriogenology. 2008. 70(3):415–20. https://doi.org/10.1016/j.theriogenology.2008.05.040 LeBlanc MM. Advances in the Diagnosis and Treatment of Chronic Infectious and Post-Mating-Induced Endometritis in the Mare. Reproduction in Domestic Animals. 2010 45(Suppl. 2):21–27. https://doi.org/10.1111/j.1439-0531.2010.01634.x Cervantes CC, Brown MP, Gronwall R, and Merritt K. 1993. Pharmacokinetics and Concentrations of Ceftiofur Sodium in Body Fluids and Endometrium after Repeated Intramuscular Injections in Mares. Am J Vet Res. 1993. 54:573–575. https://pubmed.ncbi.nlm.nih.gov/8484577/ Jonker FH. Secretion of Ceftiofur in Equine Endometrium after Parenteral Administration. Vet Pharmacol Therap. 1997. 20:(Suppl):37. http://agris.fao.org/agris-search/search.do?recordID=GB1997026008 Nash D, Lane E, Herath S, Sheldon M. Endometrial Explant Culture for Characterizing Equine Endometritis. Am J Reprod Immunol. 2008 59(2):105–117. https://doi.org/10.1111/j.1600-0897.2007.00548.x Collard WT, Cox SR., Lesman SP, Grover GS, Boucher JF, Hallberg JW, and Robinson SA and Brown JA. Pharmacokinetics of Ceftiofur Crystalline-Free Acid Sterile Suspension in the Equine. Vet Pharmacol. 2011. 34(5):476–481. https://doi.org/10.1111/j.1365-2885.2011.01266.x Scofield D, Black J, Wittenburg L, Gustafson D, Ferris R, Hatzel J, Traub - Dargatz J, McCue P. Endometrial Tissue and Blood Plasma Concentration of Ceftiofur and Metabolites Following Intramuscular Administration of Ceftiofur Crystalline Free Acid to Mares. Equine Veterinary Journal. 2014. 46(5):606–610. https://doi.org/10.1111/evj.12192 Canisso IF, Coutinho DS. Bacterial Endometritis. Robinson’s Current Therapy in Equine Medicine. Saunders, Elsevier; 2015. https://doi.org/10.1016/B978-1-4557-4555-5.00163-1 Gores-Lindholm, Alicia R. et al. Relationships between Intrauterine Infusion of N-Acetylcysteine, Equine Endometrial Pathology, Neutrophil Function, Post-Breeding Therapy, and Reproductive Performance. Theriogenology. 2013 80(3):218–227. http://dx.doi.org/10.1016/j.theriogenology.2013.03.026 Sosa AM, Mahmoud EA. Ultrasonographic, Cytological and Bacteriological Investigation of Endometritis in Arabian Mares. Global Veterinaria. 15(3):296-303. https://www.idosi.org/gv/gv15(3)15/6.pdf Rodriguez JS, et al. Consequences of Intrauterine Enrofloxacin Infusion on Mare Endometrium. Journal of Equine Veterinary Science. 2012; 32(2):106–111. http://dx.doi.org/10.1016/j.jevs.2011.08.003 Pedersoli WM, Fazeli MH, Haddad NS, Ravis WR, Carson RL. Eudometrial AmY Serum Gentamicin Conwn-Tration in Pony .Xares given Repeated Intrauterine Infusion. Am J Vet Res. 1985; 46(5):1025-1028. https://www.ncbi.nlm.nih.gov/pubmed/4003879 Linton JK, Sertich PL. The Impact of Low-Volume Uterine Lavage on Endometrial Biopsy Classification. Theriogenology. 2016; 86(4):1004–1007. http://dx.doi.org/10.1016/j.theriogenology.2016.03.028 |
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