Titulo:
Genes, the serotonergic system and suicidal behavior
.
Guardado en:
2011-2084
2011-7922
5
2012-06-30
52
58
International Journal of Psychological Research - 2012
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
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metarevistapublica_unisanbuenaventura_internationaljournalofpsychologicalresearch_21_article_751 |
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ojs |
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Genes, the serotonergic system and suicidal behavior Genes, the serotonergic system and suicidal behavior The study of suicidal behavior has gained relevance given that recently about 50% of the population between 14 and 19 years old exhibit suicidal ideation and, in the population in general, there has been a rise of up to 150% in suicidal behavior. The outcomes of these studies of genetic epidemiology show that several genes may be associated with suicidal behavior. In particular, one of the hypotheses propounds that genes of proteins that participate in the serotonergic pathway could be responsible for the development of this behavior. There is neurochemical evidence showing alterations at different levels along this pathway. In this work, a review is made of several of the genes participating in the serotonergic pathway and their possible participation in suicidal behavior. Tovilla-Zarate, Carlos Alfonso Gómez Mendoza, Alma Delia Suicide serotonin genetics polymorphism association studies 5 1 Artículo de revista Journal article 2012-06-30T00:00:00Z 2012-06-30T00:00:00Z 2012-06-30 application/pdf Universidad San Buenaventura - USB (Colombia) International Journal of Psychological Research 2011-2084 2011-7922 https://revistas.usb.edu.co/index.php/IJPR/article/view/751 10.21500/20112084.751 https://doi.org/10.21500/20112084.751 eng https://creativecommons.org/licenses/by-nc-sa/4.0/ International Journal of Psychological Research - 2012 52 58 Anguelova, M., Benkelfat, C., & Turecki, G. (2003). A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Molecular Psychiatry, 8(7), 646-653. Arango, V., Underwood, M. D., Gubbi, A. V., & Mann, J. J. (1995). Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research, 688(1-2), 121-133. Asberg, M., Traskman, L., & Thoren, P. (1976). 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Archives of General Psychiatry, 33(10), 1193-1197. Baldessarini, R. J. & Hennen, J. (2004). Genetics of suicide: an overview. Harvard of Review Psychiatry, 12(1), 1-13. Beck, A. T., Weissman, A., Lester, D., & Trexler, L. (1976). Classification of suicidal behaviors. II. Dimensions of suicidal intent. Archives of General Psychiatry, 33(7), 835-837. Bellivier, F., Chaste, P., & Malafosse, A. (2004). Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. American Journal of Medical Genetics. Part B Neuropsychiatric Genetics, 124B(1), 87-91. https://revistas.usb.edu.co/index.php/IJPR/article/download/751/550 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication |
| institution |
UNIVERSIDAD DE SAN BUENAVENTURA |
| thumbnail |
https://nuevo.metarevistas.org/UNIVERSIDADDESANBUENAVENTURA_COLOMBIA/logo.png |
| country_str |
Colombia |
| collection |
International Journal of Psychological Research |
| title |
Genes, the serotonergic system and suicidal behavior |
| spellingShingle |
Genes, the serotonergic system and suicidal behavior Tovilla-Zarate, Carlos Alfonso Gómez Mendoza, Alma Delia Suicide serotonin genetics polymorphism association studies |
| title_short |
Genes, the serotonergic system and suicidal behavior |
| title_full |
Genes, the serotonergic system and suicidal behavior |
| title_fullStr |
Genes, the serotonergic system and suicidal behavior |
| title_full_unstemmed |
Genes, the serotonergic system and suicidal behavior |
| title_sort |
genes, the serotonergic system and suicidal behavior |
| description_eng |
The study of suicidal behavior has gained relevance given that recently about 50% of the population between 14 and 19 years old exhibit suicidal ideation and, in the population in general, there has been a rise of up to 150% in suicidal behavior. The outcomes of these studies of genetic epidemiology show that several genes may be associated with suicidal behavior. In particular, one of the hypotheses propounds that genes of proteins that participate in the serotonergic pathway could be responsible for the development of this behavior. There is neurochemical evidence showing alterations at different levels along this pathway. In this work, a review is made of several of the genes participating in the serotonergic pathway and their possible participation in suicidal behavior.
|
| author |
Tovilla-Zarate, Carlos Alfonso Gómez Mendoza, Alma Delia |
| author_facet |
Tovilla-Zarate, Carlos Alfonso Gómez Mendoza, Alma Delia |
| topic |
Suicide serotonin genetics polymorphism association studies |
| topic_facet |
Suicide serotonin genetics polymorphism association studies |
| citationvolume |
5 |
| citationissue |
1 |
| publisher |
Universidad San Buenaventura - USB (Colombia) |
| ispartofjournal |
International Journal of Psychological Research |
| source |
https://revistas.usb.edu.co/index.php/IJPR/article/view/751 |
| language |
eng |
| format |
Article |
| rights |
https://creativecommons.org/licenses/by-nc-sa/4.0/ International Journal of Psychological Research - 2012 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
| references_eng |
Anguelova, M., Benkelfat, C., & Turecki, G. (2003). A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Molecular Psychiatry, 8(7), 646-653. Arango, V., Underwood, M. D., Gubbi, A. V., & Mann, J. J. (1995). Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research, 688(1-2), 121-133. Asberg, M., Traskman, L., & Thoren, P. (1976). 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Archives of General Psychiatry, 33(10), 1193-1197. Baldessarini, R. J. & Hennen, J. (2004). Genetics of suicide: an overview. Harvard of Review Psychiatry, 12(1), 1-13. Beck, A. T., Weissman, A., Lester, D., & Trexler, L. (1976). Classification of suicidal behaviors. II. Dimensions of suicidal intent. Archives of General Psychiatry, 33(7), 835-837. Bellivier, F., Chaste, P., & Malafosse, A. (2004). Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. American Journal of Medical Genetics. Part B Neuropsychiatric Genetics, 124B(1), 87-91. |
| type_driver |
info:eu-repo/semantics/article |
| type_coar |
http://purl.org/coar/resource_type/c_6501 |
| type_version |
info:eu-repo/semantics/publishedVersion |
| type_coarversion |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| type_content |
Text |
| publishDate |
2012-06-30 |
| date_accessioned |
2012-06-30T00:00:00Z |
| date_available |
2012-06-30T00:00:00Z |
| url |
https://revistas.usb.edu.co/index.php/IJPR/article/view/751 |
| url_doi |
https://doi.org/10.21500/20112084.751 |
| issn |
2011-2084 |
| eissn |
2011-7922 |
| doi |
10.21500/20112084.751 |
| citationstartpage |
52 |
| citationendpage |
58 |
| url2_str_mv |
https://revistas.usb.edu.co/index.php/IJPR/article/download/751/550 |
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1811200829517987840 |