Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad

Palacio, Juan David; Gomez-Valero, Maria Alejandra; Bustamante-Gomez, Paula Andrea; Arroyave-Sierra, Pilar; Vargas-Upegui, Cristian David; Pineda-Zapata, Julian; Castrillon, Gabriel; Aguirre-Acevedo, Daniel Camilo; Lopez-Jaramillo, Carlos

doi:10.21500/20112084.3971

Titulo:

Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad
.

Sumario:

Los hallazgos neuroanatómicos en la red límbica anterior en el trastorno bipolar (TB) en adultos no se han replicado en otras poblaciones, como en los hijos de pacientes con trastorno bipolar (HPTB). El objetivo de este estudio fue comparar los volúmenes de áreas del cerebro entre HPTB, con y sin algún trastorno afectivo (TA) a lo largo de la vida, con un grupo de hijos de padres control de la comunidad (HPC). Métodos: Se realizó un estudio observacional, descriptivo y transversal, con múltiples grupos de comparación. Siete sujetos (11-17 años) del grupo HPTB con TA se compararon con siete sujetos del grupo HPTB sin TA y siete sujetos del grupo HPC (pareados por edad, sexo y estadio Tanner). La resonancia magnética nuclear se realizó con un... Ver más

Guardado en:

Revista:

International Journal of Psychological Research

ISSN:

2011-2084

EISSN:

2011-7922

Autores:

Palacio, Juan David

Gomez-Valero, Maria Alejandra

Bustamante-Gomez, Paula Andrea

Arroyave-Sierra, Pilar

Vargas-Upegui, Cristian David

Pineda-Zapata, Julian

Castrillon, Gabriel

Aguirre-Acevedo, Daniel Camilo

Lopez-Jaramillo, Carlos

Editor:

UNIVERSIDAD DE SAN BUENAVENTURA

DOI:

10.21500/20112084.3971

Volumen:

Año de publicación:

2019-09-05

Pagina inicial:

Pagina final:

Pais:

Colombia

Palabras claves:

amígdala

corteza prefrontal

Hijos de paciente con trastorno bipolar

población de alto riesgo

trastorno bipolar

Resonancia magnética nuclear

Licencia:

http://purl.org/coar/access_right/c_abf2

info:eu-repo/semantics/openAccess

International Journal of Psychological Research - 2019

id	metarevistapublica_unisanbuenaventura_internationaljournalofpsychologicalresearch_21-article-3971
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institution	UNIVERSIDAD DE SAN BUENAVENTURA
thumbnail	https://nuevo.metarevistas.org/UNIVERSIDADDESANBUENAVENTURA_COLOMBIA/logo.png
country_str	Colombia
collection	International Journal of Psychological Research
title	Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad
spellingShingle	Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad Palacio, Juan David Gomez-Valero, Maria Alejandra Bustamante-Gomez, Paula Andrea Arroyave-Sierra, Pilar Vargas-Upegui, Cristian David Pineda-Zapata, Julian Castrillon, Gabriel Aguirre-Acevedo, Daniel Camilo Lopez-Jaramillo, Carlos amígdala corteza prefrontal Hijos de paciente con trastorno bipolar población de alto riesgo trastorno bipolar Resonancia magnética nuclear Magnetic Resonance Imaging bipolar offspring’s Bipolar Disorder high-risk population amygdala prefrontal cortex
title_short	Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad
title_full	Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad
title_fullStr	Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad
title_full_unstemmed	Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad
title_sort	diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad
description	Los hallazgos neuroanatómicos en la red límbica anterior en el trastorno bipolar (TB) en adultos no se han replicado en otras poblaciones, como en los hijos de pacientes con trastorno bipolar (HPTB). El objetivo de este estudio fue comparar los volúmenes de áreas del cerebro entre HPTB, con y sin algún trastorno afectivo (TA) a lo largo de la vida, con un grupo de hijos de padres control de la comunidad (HPC). Métodos: Se realizó un estudio observacional, descriptivo y transversal, con múltiples grupos de comparación. Siete sujetos (11-17 años) del grupo HPTB con TA se compararon con siete sujetos del grupo HPTB sin TA y siete sujetos del grupo HPC (pareados por edad, sexo y estadio Tanner). La resonancia magnética nuclear se realizó con un resonador Philips 3 Teslas y la segmentación volumétrica se realizó con el conjunto de análisis de imagen Freesurfer. Resultados: Se encontró un tamaño mayor en la región frontal rostral medial derecha en el grupo HPTB con TA en comparación con los otros dos grupos (p = 0.041). También se encontró un mayor volumen en el grupo HPTB con TA en el opérculo frontal izquierdo (Cohen d = 0,63) y en el istmo del giro del cíngulo derecho (d = 0,53) cuando se comparó con el grupo sin TA, y en el hipocampo derecho (d = 0,53) en comparación con el grupo HPC. Se encontró un volumen más pequeño en el grupo HPTB sin TA versus grupo HPC en el caudado anterior izquierdo (d = 0,6). Los grupos HPTB (con y sin TA) en comparación con HPC tienen un volumen mayor en el polo frontal derecho (d = 0.52). Estas diferencias volumétricas pueden atribuirse a la condición de HPTB con TA.
description_eng	Neuroanatomical findings in the anterior limbic network in bipolar disorder (BD) adults have not been replicated in other populations such as bipolar offspring (BO). The aim of this study was to compare some brain areas volumes between BO with and without a lifetime affective disorder (AD) to a group of community control offspring (CCO). Methods: A descriptive observational cross-sectional study was carried out, with multiple comparison groups. Seven subjects (11-17 years old) from the BO with AD group were compared to seven subjects from the BO without AD group and seven subjects from the CCO group (match by age, gender and Tanner stage). Magnetic resonance imaging was performed with a Philips 3 Teslas device and volumetric segmentation was performed with the Freesurfer image analysis suite. Results: A larger size was found in the right middle frontal rostral region in the BO with AD group compared to the other two groups (p = 0.041). A higher volume was also found in BO with AD group in the left pars opercularis (Cohen d = 0.63) and in the right cingulate isthmus (d = 0.53) when compared with BO without AD group, and in the right hippocampus (d = 0.53) when compared to CCO group. A smaller volume was found in the BO without AD group versus CCO group in the left anterior caudate (d = 0.6). The BO groups (with and without AD) compared to CCO have a higher volume in the right frontal pole (d = 0.52). These volumetric differences can be attributed to the condition of BO with AD.
author	Palacio, Juan David Gomez-Valero, Maria Alejandra Bustamante-Gomez, Paula Andrea Arroyave-Sierra, Pilar Vargas-Upegui, Cristian David Pineda-Zapata, Julian Castrillon, Gabriel Aguirre-Acevedo, Daniel Camilo Lopez-Jaramillo, Carlos
author_facet	Palacio, Juan David Gomez-Valero, Maria Alejandra Bustamante-Gomez, Paula Andrea Arroyave-Sierra, Pilar Vargas-Upegui, Cristian David Pineda-Zapata, Julian Castrillon, Gabriel Aguirre-Acevedo, Daniel Camilo Lopez-Jaramillo, Carlos
topicspa_str_mv	amígdala corteza prefrontal Hijos de paciente con trastorno bipolar población de alto riesgo trastorno bipolar Resonancia magnética nuclear
topic	amígdala corteza prefrontal Hijos de paciente con trastorno bipolar población de alto riesgo trastorno bipolar Resonancia magnética nuclear Magnetic Resonance Imaging bipolar offspring’s Bipolar Disorder high-risk population amygdala prefrontal cortex
topic_facet	amígdala corteza prefrontal Hijos de paciente con trastorno bipolar población de alto riesgo trastorno bipolar Resonancia magnética nuclear Magnetic Resonance Imaging bipolar offspring’s Bipolar Disorder high-risk population amygdala prefrontal cortex
citationvolume	12
citationissue	2
citationedition	Núm. 2 , Año 2019 : Volume 12(2)
publisher	Universidad San Buenaventura - USB (Colombia)
ispartofjournal	International Journal of Psychological Research
source	https://revistas.usb.edu.co/index.php/IJPR/article/view/3971
language	Inglés
format	Article
rights	http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ International Journal of Psychological Research - 2019
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spelling	Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad Artículo de revista amígdala corteza prefrontal Hijos de paciente con trastorno bipolar población de alto riesgo trastorno bipolar Resonancia magnética nuclear Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad Los hallazgos neuroanatómicos en la red límbica anterior en el trastorno bipolar (TB) en adultos no se han replicado en otras poblaciones, como en los hijos de pacientes con trastorno bipolar (HPTB). El objetivo de este estudio fue comparar los volúmenes de áreas del cerebro entre HPTB, con y sin algún trastorno afectivo (TA) a lo largo de la vida, con un grupo de hijos de padres control de la comunidad (HPC). Métodos: Se realizó un estudio observacional, descriptivo y transversal, con múltiples grupos de comparación. Siete sujetos (11-17 años) del grupo HPTB con TA se compararon con siete sujetos del grupo HPTB sin TA y siete sujetos del grupo HPC (pareados por edad, sexo y estadio Tanner). La resonancia magnética nuclear se realizó con un resonador Philips 3 Teslas y la segmentación volumétrica se realizó con el conjunto de análisis de imagen Freesurfer. Resultados: Se encontró un tamaño mayor en la región frontal rostral medial derecha en el grupo HPTB con TA en comparación con los otros dos grupos (p = 0.041). También se encontró un mayor volumen en el grupo HPTB con TA en el opérculo frontal izquierdo (Cohen d = 0,63) y en el istmo del giro del cíngulo derecho (d = 0,53) cuando se comparó con el grupo sin TA, y en el hipocampo derecho (d = 0,53) en comparación con el grupo HPC. Se encontró un volumen más pequeño en el grupo HPTB sin TA versus grupo HPC en el caudado anterior izquierdo (d = 0,6). Los grupos HPTB (con y sin TA) en comparación con HPC tienen un volumen mayor en el polo frontal derecho (d = 0.52). Estas diferencias volumétricas pueden atribuirse a la condición de HPTB con TA. info:eu-repo/semantics/article application/pdf Text http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/publishedVersion text/xml American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (Fifth Edit). Arlington, VA: American Psychiatric Publishing, Inc. Axelson, D., Goldstein, B., Goldstein, TRMonk, K., Yu, H., Hickey, M., & Al., E. (2015). Diagnostic Precursors to Bipolar Disorder in Offspring of Parents With Bipolar Disorder: A Longitudinal Study. 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Psychiatry Research, 131(1), 57-69. doi:10.1016/j.pscychresns.2004.01.004 Universidad San Buenaventura - USB (Colombia) International Journal of Psychological Research https://revistas.usb.edu.co/index.php/IJPR/article/view/3971 http://purl.org/coar/resource_type/c_6501 https://creativecommons.org/licenses/by-nc-sa/4.0/ International Journal of Psychological Research - 2019 Inglés Journal article Núm. 2 , Año 2019 : Volume 12(2) 2 Neuroanatomical findings in the anterior limbic network in bipolar disorder (BD) adults have not been replicated in other populations such as bipolar offspring (BO). The aim of this study was to compare some brain areas volumes between BO with and without a lifetime affective disorder (AD) to a group of community control offspring (CCO). Methods: A descriptive observational cross-sectional study was carried out, with multiple comparison groups. Seven subjects (11-17 years old) from the BO with AD group were compared to seven subjects from the BO without AD group and seven subjects from the CCO group (match by age, gender and Tanner stage). Magnetic resonance imaging was performed with a Philips 3 Teslas device and volumetric segmentation was performed with the Freesurfer image analysis suite. Results: A larger size was found in the right middle frontal rostral region in the BO with AD group compared to the other two groups (p = 0.041). A higher volume was also found in BO with AD group in the left pars opercularis (Cohen d = 0.63) and in the right cingulate isthmus (d = 0.53) when compared with BO without AD group, and in the right hippocampus (d = 0.53) when compared to CCO group. A smaller volume was found in the BO without AD group versus CCO group in the left anterior caudate (d = 0.6). The BO groups (with and without AD) compared to CCO have a higher volume in the right frontal pole (d = 0.52). These volumetric differences can be attributed to the condition of BO with AD. Palacio, Juan David Gomez-Valero, Maria Alejandra Bustamante-Gomez, Paula Andrea Arroyave-Sierra, Pilar Vargas-Upegui, Cristian David Pineda-Zapata, Julian Castrillon, Gabriel Aguirre-Acevedo, Daniel Camilo Lopez-Jaramillo, Carlos Magnetic Resonance Imaging Publication bipolar offspring’s Bipolar Disorder 12 high-risk population amygdala prefrontal cortex 2019-09-05T22:27:21Z 2019-09-05T22:27:21Z 2019-09-05 10.21500/20112084.3971 https://doi.org/10.21500/20112084.3971 https://revistas.usb.edu.co/index.php/IJPR/article/download/3971/3430 58 48 2011-2084 2011-7922 https://revistas.usb.edu.co/index.php/IJPR/article/download/3971/3667

Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad .

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Diferencias volumétricas de la corteza frontal rostro medial en hijos de pacientes con trastorno afectivo bipolar e hijos de padres control de la comunidad
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