Titulo:
Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro
.
Sumario:
Este artículo de revisión presenta las estrategias más apropiadas para el estudio de endofenotipos en los trastornos de personalidad. Actualmente existen muchos estudios neurobiológicos y moleculares que sugieren una predisposición genética a diferentes rasgos representativos expresados en dichos trastornos. No obstante, la replicación exitosa de tales resultados no ha sido posible, debido a dificultades relacionadas a la sensibilidad, especificidad y validación de los métodos implementados en las evaluaciones clínicas; el tamaño y tipo de poblaciones elegidas, y los diseños experimentales implementados. Desafortunadamente, los diagnósticos hechos en psiquiatría y psicología cuentan con un sistema de clasificación basado en la prevalencia y... Ver más
Guardado en:
2011-2084
2011-7922
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2015-01-01
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112
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
International Journal of Psychological Research - 2016
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metarevistapublica_unisanbuenaventura_internationaljournalofpsychologicalresearch_21-article-2105 |
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ojs |
| institution |
UNIVERSIDAD DE SAN BUENAVENTURA |
| thumbnail |
https://nuevo.metarevistas.org/UNIVERSIDADDESANBUENAVENTURA_COLOMBIA/logo.png |
| country_str |
Colombia |
| collection |
International Journal of Psychological Research |
| title |
Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro |
| spellingShingle |
Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro Valencia Piedrahita, Manuela Cuartas Arias, Jorge Mauricio genes candidatos. biomarcadores ERPs trastornos de personalidad personality disorders ERPs biomarkers candidate genes. |
| title_short |
Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro |
| title_full |
Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro |
| title_fullStr |
Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro |
| title_full_unstemmed |
Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro |
| title_sort |
potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro |
| description |
Este artículo de revisión presenta las estrategias más apropiadas para el estudio de endofenotipos en los trastornos de personalidad. Actualmente existen muchos estudios neurobiológicos y moleculares que sugieren una predisposición genética a diferentes rasgos representativos expresados en dichos trastornos. No obstante, la replicación exitosa de tales resultados no ha sido posible, debido a dificultades relacionadas a la sensibilidad, especificidad y validación de los métodos implementados en las evaluaciones clínicas; el tamaño y tipo de poblaciones elegidas, y los diseños experimentales implementados. Desafortunadamente, los diagnósticos hechos en psiquiatría y psicología cuentan con un sistema de clasificación basado en la prevalencia y la intensidad de los síntomas, sin tener en cuenta la etiología, neurobiología, epidemiología, genética y la respuesta a los medicamentos. Por otra parte, explicar la fenomenología de los trastornos de personalidad y como los genes expresan el fenotipo, implica una revisión de la teoría del caos, direccionándola a la conexión entre en neurodesarrollo, eventos estresantes significativos durante la infancia temprana y modificaciones en el ADN asociados a eventos estocásticos que contribuyen al desarrollo de conductas normales y anormales.
|
| description_eng |
This review article presents the most appropriate strategies for examining the phenotype for personality disorders. At present there are many neurobiological and molecular studies that suggest a genetic predisposition to different traits representative of expressed personality disorders. Nonetheless, it has not been possible to accurately and successfully replicate such results due to some difficulties regarding the sensitivity, specificity and validity of the clinical evaluation methods, and the size and type of the chosen population and experimental designs used for research. Unfortunately, diagnoses done in psychiatry and psychology have a classification system based on the prevalence and intensity of symptoms and do not take into account the etiology, neurobiology, epidemiology, genetics, and drug responses. On the other hand, explaining the phenomenology of personality disorderes and how genes work together to express this phenotype implies a revision of the chaos theory, addressing the connection between neurodevelopment, significantly stressful events during early childhood and epigenetic modifications in DNA related to stochastic events which may contribute to the development of normal or abnormal behavior
|
| author |
Valencia Piedrahita, Manuela Cuartas Arias, Jorge Mauricio |
| author_facet |
Valencia Piedrahita, Manuela Cuartas Arias, Jorge Mauricio |
| topicspa_str_mv |
genes candidatos. biomarcadores ERPs trastornos de personalidad |
| topic |
genes candidatos. biomarcadores ERPs trastornos de personalidad personality disorders ERPs biomarkers candidate genes. |
| topic_facet |
genes candidatos. biomarcadores ERPs trastornos de personalidad personality disorders ERPs biomarkers candidate genes. |
| citationvolume |
9 |
| citationissue |
1 |
| publisher |
Universidad San Buenaventura - USB (Colombia) |
| ispartofjournal |
International Journal of Psychological Research |
| source |
https://revistas.usb.edu.co/index.php/IJPR/article/view/2105 |
| language |
Inglés |
| format |
Article |
| rights |
info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 International Journal of Psychological Research - 2016 https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| references_eng |
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Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro Potenciales biomarcadores en trastornos de la personalidad: estado actual y trabajo futuro Artículo de revista genes candidatos. biomarcadores ERPs trastornos de personalidad Este artículo de revisión presenta las estrategias más apropiadas para el estudio de endofenotipos en los trastornos de personalidad. Actualmente existen muchos estudios neurobiológicos y moleculares que sugieren una predisposición genética a diferentes rasgos representativos expresados en dichos trastornos. No obstante, la replicación exitosa de tales resultados no ha sido posible, debido a dificultades relacionadas a la sensibilidad, especificidad y validación de los métodos implementados en las evaluaciones clínicas; el tamaño y tipo de poblaciones elegidas, y los diseños experimentales implementados. Desafortunadamente, los diagnósticos hechos en psiquiatría y psicología cuentan con un sistema de clasificación basado en la prevalencia y la intensidad de los síntomas, sin tener en cuenta la etiología, neurobiología, epidemiología, genética y la respuesta a los medicamentos. Por otra parte, explicar la fenomenología de los trastornos de personalidad y como los genes expresan el fenotipo, implica una revisión de la teoría del caos, direccionándola a la conexión entre en neurodesarrollo, eventos estresantes significativos durante la infancia temprana y modificaciones en el ADN asociados a eventos estocásticos que contribuyen al desarrollo de conductas normales y anormales. info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:eu-repo/semantics/article http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Allen, N. B., Lewinsohn, P. M., & Seeley, J. R. (1998). 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European child & adolescent psychiatry, 19(3), 199-210. doi: 10.1007/s00787-009-0082-z World Health Organization. (2005). ICD-10 international statistical classification of diseases and related health problems (pp. 1 CD-ROM 4 3/4 in.). International Journal of Psychological Research - 2016 https://creativecommons.org/licenses/by-nc-sa/4.0/ Inglés https://revistas.usb.edu.co/index.php/IJPR/article/view/2105 International Journal of Psychological Research Universidad San Buenaventura - USB (Colombia) application/pdf 9 This review article presents the most appropriate strategies for examining the phenotype for personality disorders. At present there are many neurobiological and molecular studies that suggest a genetic predisposition to different traits representative of expressed personality disorders. Nonetheless, it has not been possible to accurately and successfully replicate such results due to some difficulties regarding the sensitivity, specificity and validity of the clinical evaluation methods, and the size and type of the chosen population and experimental designs used for research. Unfortunately, diagnoses done in psychiatry and psychology have a classification system based on the prevalence and intensity of symptoms and do not take into account the etiology, neurobiology, epidemiology, genetics, and drug responses. On the other hand, explaining the phenomenology of personality disorderes and how genes work together to express this phenotype implies a revision of the chaos theory, addressing the connection between neurodevelopment, significantly stressful events during early childhood and epigenetic modifications in DNA related to stochastic events which may contribute to the development of normal or abnormal behavior Valencia Piedrahita, Manuela Cuartas Arias, Jorge Mauricio personality disorders ERPs biomarkers candidate genes. Publication 1 Journal article 98 2015-01-01 https://revistas.usb.edu.co/index.php/IJPR/article/download/2105/1838 2016-01-01T00:00:00Z https://doi.org/10.21500/20112084.2105 10.21500/20112084.2105 2016-01-01T00:00:00Z 2011-7922 2011-2084 112 |