Utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
Titulo:

Utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
.

Sumario:

Introducción: El síncope vasovagal es la principal causa de pérdida transitoria de la conciencia, y es un motivo de consulta cada vez más frecuente en pediatría y medicina del adulto. La midodrina es un agonista de los receptores alfa, de acción periférica, empleada principalmente en el manejo de la hipotensión ortostática; sin embargo, también se ha evaluado en el síncope vasovagal, con resultados prometedores. Objetivo: Analizar la evidencia más reciente sobre la utilidad de la midodrina para el control y la prevención del síncope vasovagal. Materiales y métodos: Se realizó una búsqueda bibliográfica utilizando términos de búsqueda como Vasovagal Syncope y Midodrine, así como sinónimos, que se combinaron con operadores booleanos, en cinco... Ver más

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Revista Investigación en Salud Universidad de Boyacá

2389-7325

2539-2018

Picón-Jaimes, Yelson Alejandro

Toro-Gómez, Diana María

Castillo-Restrepo, Manuela

Sánchez-Estrada, Luis Fernando

Cárdenas-Bravo, Diego Fernando

Acosta-Agámez , Diana Marcela

Gómez-Galán, María Alejandra

Chamorro-Azuaje, Teosmar Jhonswaldo

Salcedo-Pacheco, María del Carmen

UNIVERSIDAD DE BOYACÁ

10.24267/23897325.890

10

2023-03-31

112

128

Colombia

midodrina

síncope vasovagal

sincope

adrenérgicos

medicina basada en la evidencia

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spelling Utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
Usefulness of Midodrine for the Control of Recurrent Vasovagal Syncope: Does the Evidence Recommend it?
Introducción: El síncope vasovagal es la principal causa de pérdida transitoria de la conciencia, y es un motivo de consulta cada vez más frecuente en pediatría y medicina del adulto. La midodrina es un agonista de los receptores alfa, de acción periférica, empleada principalmente en el manejo de la hipotensión ortostática; sin embargo, también se ha evaluado en el síncope vasovagal, con resultados prometedores. Objetivo: Analizar la evidencia más reciente sobre la utilidad de la midodrina para el control y la prevención del síncope vasovagal. Materiales y métodos: Se realizó una búsqueda bibliográfica utilizando términos de búsqueda como Vasovagal Syncope y Midodrine, así como sinónimos, que se combinaron con operadores booleanos, en cinco bases de datos, hasta octubre del 2022. Se incluyeron estudios originales, revisiones sistemá- ticas y metanálisis, publicados tanto en inglés como en español. Resultados: Ensayos controlados aleatorizados y revisiones sistemáticas y metanálisis difieren ligeramente entre resultados, pero estos demuestran un efecto global protector. La evidencia más reciente y completa indica que utilizar este agente reduce significativamente la positividad al realizar la prueba de la mesa inclinada y que previene la aparición de episodios sincopales. Conclusiones: Aunque la evidencia actual sobre la eficacia de la midodrina respecto a la prevención y control del síncope vasovagal es limitada, se observa un efecto protector significativo, porque disminuye el riesgo de sufrir un episodio sincopal, aproximadamente hasta en un 50%.
Introduction: Vasovagal syncope is the main cause of transient loss of consciousness, being an increasingly frequent reason for consultation in pediatrics and adult medicine. Midodrine, a peripherally acting alpha-receptor agonist, is mainly used in the management of orthostatic hypotension. However, it has also been evaluated in vasovagal syncope, with promising results. Objective: To analyze the most recent evidence on the usefulness of midodrine for the control and prevention of vasovagal syncope. Materials and Methods: A literature search was performed using search terms such as “Vasovagal Syncope” and “Midodrine,” as well as synonyms, which were combined with Boolean operators, in 5 databases until October 2022. Original studies, systematic reviews and meta-analyses, published in both English and Spanish, were included. Results: Randomized controlled trials and systematic reviews and meta-analyses differ slightly between results, but these demonstrate an overall protective effect. The most recent and complete evidence shows that using this agent significantly reduces the probability of positivity when performing the tilt table test and prevents the occurrence of syncopal episodes. Conclusions: Although current evidence on the efficacy of midodrine with respect to the prevention and control of vasovagal syncope is limited, a significant protective effect is observed, reducing the risk of suffering syncopal episode by approximately up to 50%.
Picón-Jaimes, Yelson Alejandro
Toro-Gómez, Diana María
Castillo-Restrepo, Manuela
Sánchez-Estrada, Luis Fernando
Cárdenas-Bravo, Diego Fernando
Acosta-Agámez , Diana Marcela
Gómez-Galán, María Alejandra
Chamorro-Azuaje, Teosmar Jhonswaldo
Salcedo-Pacheco, María del Carmen
midodrina
síncope vasovagal
sincope
adrenérgicos
medicina basada en la evidencia
midodrine
vasovagal syncope
syncope
adrenergic agents
evidence-based medicine
midodrina
síncope vasovagal
síncope
adrenérgicos
medicina baseada em evidências
10
1
Núm. 1 , Año 2023 : Revista Investigación en Salud Universidad de Boyacá
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2023-03-31T00:00:00Z
2023-03-31T00:00:00Z
2023-03-31
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Universidad de Boyacá
Revista Investigación en Salud Universidad de Boyacá
2389-7325
2539-2018
https://revistasdigitales.uniboyaca.edu.co/index.php/rs/article/view/890
10.24267/23897325.890
https://doi.org/10.24267/23897325.890
spa
http://creativecommons.org/licenses/by-nc/4.0
La Revista Investigación en Salud (ISUB) es una publicación que sigue los términos de la licencia Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) la cual permite con una adecuada citación que los manuscritos sean usados de forma ilimitada; esta publicación se declara como de acceso abierto. Se conservan los derechos de autoría de los investigadores sobre su artículo; mientras que los derechos comerciales de publicación y los derechos para la publicación de compilaciones o traducciones de los manuscritos los conserva la Revista ISUB. Los datos personales de los autores que figuran en los manuscritos (nombres, direcciones de correo, ORCID y filiación) serán usados únicamente para los fines declarados de divulgación científica por la revista. - 2023
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
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Text
Publication
institution UNIVERSIDAD DE BOYACÁ
thumbnail https://nuevo.metarevistas.org/UNIVERSIDADDEBOYACA/logo.png
country_str Colombia
collection Revista Investigación en Salud Universidad de Boyacá
title Utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
spellingShingle Utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
Picón-Jaimes, Yelson Alejandro
Toro-Gómez, Diana María
Castillo-Restrepo, Manuela
Sánchez-Estrada, Luis Fernando
Cárdenas-Bravo, Diego Fernando
Acosta-Agámez , Diana Marcela
Gómez-Galán, María Alejandra
Chamorro-Azuaje, Teosmar Jhonswaldo
Salcedo-Pacheco, María del Carmen
midodrina
síncope vasovagal
sincope
adrenérgicos
medicina basada en la evidencia
midodrine
vasovagal syncope
syncope
adrenergic agents
evidence-based medicine
midodrina
síncope vasovagal
síncope
adrenérgicos
medicina baseada em evidências
title_short Utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
title_full Utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
title_fullStr Utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
title_full_unstemmed Utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
title_sort utilidad de la midodrina para controlar el síncope vasovagal: ¿la recomienda la evidencia?
title_eng Usefulness of Midodrine for the Control of Recurrent Vasovagal Syncope: Does the Evidence Recommend it?
description Introducción: El síncope vasovagal es la principal causa de pérdida transitoria de la conciencia, y es un motivo de consulta cada vez más frecuente en pediatría y medicina del adulto. La midodrina es un agonista de los receptores alfa, de acción periférica, empleada principalmente en el manejo de la hipotensión ortostática; sin embargo, también se ha evaluado en el síncope vasovagal, con resultados prometedores. Objetivo: Analizar la evidencia más reciente sobre la utilidad de la midodrina para el control y la prevención del síncope vasovagal. Materiales y métodos: Se realizó una búsqueda bibliográfica utilizando términos de búsqueda como Vasovagal Syncope y Midodrine, así como sinónimos, que se combinaron con operadores booleanos, en cinco bases de datos, hasta octubre del 2022. Se incluyeron estudios originales, revisiones sistemá- ticas y metanálisis, publicados tanto en inglés como en español. Resultados: Ensayos controlados aleatorizados y revisiones sistemáticas y metanálisis difieren ligeramente entre resultados, pero estos demuestran un efecto global protector. La evidencia más reciente y completa indica que utilizar este agente reduce significativamente la positividad al realizar la prueba de la mesa inclinada y que previene la aparición de episodios sincopales. Conclusiones: Aunque la evidencia actual sobre la eficacia de la midodrina respecto a la prevención y control del síncope vasovagal es limitada, se observa un efecto protector significativo, porque disminuye el riesgo de sufrir un episodio sincopal, aproximadamente hasta en un 50%.
description_eng Introduction: Vasovagal syncope is the main cause of transient loss of consciousness, being an increasingly frequent reason for consultation in pediatrics and adult medicine. Midodrine, a peripherally acting alpha-receptor agonist, is mainly used in the management of orthostatic hypotension. However, it has also been evaluated in vasovagal syncope, with promising results. Objective: To analyze the most recent evidence on the usefulness of midodrine for the control and prevention of vasovagal syncope. Materials and Methods: A literature search was performed using search terms such as “Vasovagal Syncope” and “Midodrine,” as well as synonyms, which were combined with Boolean operators, in 5 databases until October 2022. Original studies, systematic reviews and meta-analyses, published in both English and Spanish, were included. Results: Randomized controlled trials and systematic reviews and meta-analyses differ slightly between results, but these demonstrate an overall protective effect. The most recent and complete evidence shows that using this agent significantly reduces the probability of positivity when performing the tilt table test and prevents the occurrence of syncopal episodes. Conclusions: Although current evidence on the efficacy of midodrine with respect to the prevention and control of vasovagal syncope is limited, a significant protective effect is observed, reducing the risk of suffering syncopal episode by approximately up to 50%.
author Picón-Jaimes, Yelson Alejandro
Toro-Gómez, Diana María
Castillo-Restrepo, Manuela
Sánchez-Estrada, Luis Fernando
Cárdenas-Bravo, Diego Fernando
Acosta-Agámez , Diana Marcela
Gómez-Galán, María Alejandra
Chamorro-Azuaje, Teosmar Jhonswaldo
Salcedo-Pacheco, María del Carmen
author_facet Picón-Jaimes, Yelson Alejandro
Toro-Gómez, Diana María
Castillo-Restrepo, Manuela
Sánchez-Estrada, Luis Fernando
Cárdenas-Bravo, Diego Fernando
Acosta-Agámez , Diana Marcela
Gómez-Galán, María Alejandra
Chamorro-Azuaje, Teosmar Jhonswaldo
Salcedo-Pacheco, María del Carmen
topicspa_str_mv midodrina
síncope vasovagal
sincope
adrenérgicos
medicina basada en la evidencia
topic midodrina
síncope vasovagal
sincope
adrenérgicos
medicina basada en la evidencia
midodrine
vasovagal syncope
syncope
adrenergic agents
evidence-based medicine
midodrina
síncope vasovagal
síncope
adrenérgicos
medicina baseada em evidências
topic_facet midodrina
síncope vasovagal
sincope
adrenérgicos
medicina basada en la evidencia
midodrine
vasovagal syncope
syncope
adrenergic agents
evidence-based medicine
midodrina
síncope vasovagal
síncope
adrenérgicos
medicina baseada em evidências
citationvolume 10
citationissue 1
citationedition Núm. 1 , Año 2023 : Revista Investigación en Salud Universidad de Boyacá
publisher Universidad de Boyacá
ispartofjournal Revista Investigación en Salud Universidad de Boyacá
source https://revistasdigitales.uniboyaca.edu.co/index.php/rs/article/view/890
language spa
format Article
rights http://creativecommons.org/licenses/by-nc/4.0
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publishDate 2023-03-31
date_accessioned 2023-03-31T00:00:00Z
date_available 2023-03-31T00:00:00Z
url https://revistasdigitales.uniboyaca.edu.co/index.php/rs/article/view/890
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citationstartpage 112
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