Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
Titulo:

Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
.

Sumario:

La hipercetonemia o cetosis bovina es un desorden metabólico, que se caracteriza por el incremento patológico de cuerpos cetónicos (beta-hidroxibutirato (βHB), Acetoacetato (AcAc) y acetona) y ocurre en el periparto de vacas de leche. El origen primario de la enfermedad es el balance energético negativo (BEN), que puede ser desencadenado por el incremento excesivo de los requerimientos energéticos o la presentación de enfermedades posparto, resultando en la presentación de signos clínicos o disminución de la producción de leche. El objetivo de esta revisión consiste en describir, mediante un modelo, los procesos bioquímicos del rumen y los mecanismos fisiopatológicos, involucrados con incremento excesivo de los cuerpos cetónicos. En resumen... Ver más

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Revista U.D.C.A Actualidad & Divulgación Científica

0123-4226

2619-2551

Huertas-Molina, Oscar Felípe

Londoño-Vásquez, Daniela

Olivera-Angel, Martha

UNIVERSIDAD DE CIENCIAS APLICADAS Y AMBIENTALES

10.31910/rudca.v23.n1.2020.1304

23

2020-06-30

Colombia

balance energético negativo

cetosis

cuerpos cetónicos

vaca lechera

Oscar Felípe Huertas Molina, Daniela Londoño Vásquez, Martha Olivera Angel - 2020

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spelling Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
Hyperketonemia: Biochemistry of volatile fatty acid production and its hepatic metabolism
La hipercetonemia o cetosis bovina es un desorden metabólico, que se caracteriza por el incremento patológico de cuerpos cetónicos (beta-hidroxibutirato (βHB), Acetoacetato (AcAc) y acetona) y ocurre en el periparto de vacas de leche. El origen primario de la enfermedad es el balance energético negativo (BEN), que puede ser desencadenado por el incremento excesivo de los requerimientos energéticos o la presentación de enfermedades posparto, resultando en la presentación de signos clínicos o disminución de la producción de leche. El objetivo de esta revisión consiste en describir, mediante un modelo, los procesos bioquímicos del rumen y los mecanismos fisiopatológicos, involucrados con incremento excesivo de los cuerpos cetónicos. En resumen, se realizó un modelo fisiológico uniendo literatura fragmentada, sobre la relación entre la función ruminal, hepática y la inducción de lipolisis e incremento de la actividad de Carnitil-Palmitoil transferasa-1 (CPT-1), cuyo resultado puede ser la producción excesiva de Acetil-CoA que, junto con la falta de propionato y oxalacetato (precursores de gluconeogénesis y ciclo de Krebs), dan lugar a la producción patológica de acetoacetato y beta-hidroxibutirato.
Bovine hyperketonemia or ketosis is a metabolic disorder characterized by high levels of ketone bodies (beta-hydroxybutyrate (βHB), Acetoacetate (AcAc), and acetone) in periparturient dairy cows. A Negative Energy Balance (NEB) is identified as the primary cause of the disease, which is triggered by the excessive increase of energy requirements or the presence of postpartum diseases, resulting in the appearance of clinical signs or decreased milk production. The purpose of this review is to describe the rumen’s biochemical Process and the physiopathological mechanisms involved in the excessive production of ketone bodies. After conducting a literature review, a physiological model was carried out in order to understand the relationship between the rumen and liver functions with lipolysis induction and increased CPT-1 activity. The above may result in the overproduction of Acetyl-CoA, which together, with the lack of propionate and oxaloacetate (gluconeogenesis and Krebs cycle precursors), leads to the pathological production of acetoacetate and beta-hydroxybutyrate.
Huertas-Molina, Oscar Felípe
Londoño-Vásquez, Daniela
Olivera-Angel, Martha
balance energético negativo
cetosis
cuerpos cetónicos
vaca lechera
negative energy balance
ketosis
ketone bodies
dairy cattle
23
1
Núm. 1 , Año 2020 :Revista U.D.C.A Actualidad & Divulgación Científica. Enero-Junio
Artículo de revista
Journal article
2020-06-30T00:00:00Z
2020-06-30T00:00:00Z
2020-06-30
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Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
Revista U.D.C.A Actualidad & Divulgación Científica
0123-4226
2619-2551
https://revistas.udca.edu.co/index.php/ruadc/article/view/1304
10.31910/rudca.v23.n1.2020.1304
https://doi.org/10.31910/rudca.v23.n1.2020.1304
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https://creativecommons.org/licenses/by-nc-sa/4.0/
Oscar Felípe Huertas Molina, Daniela Londoño Vásquez, Martha Olivera Angel - 2020
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title Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
spellingShingle Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
Huertas-Molina, Oscar Felípe
Londoño-Vásquez, Daniela
Olivera-Angel, Martha
balance energético negativo
cetosis
cuerpos cetónicos
vaca lechera
negative energy balance
ketosis
ketone bodies
dairy cattle
title_short Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_full Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_fullStr Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_full_unstemmed Hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_sort hipercetonemia: bioquímica de la producción de ácidos grasos volátiles y su metabolismo hepático
title_eng Hyperketonemia: Biochemistry of volatile fatty acid production and its hepatic metabolism
description La hipercetonemia o cetosis bovina es un desorden metabólico, que se caracteriza por el incremento patológico de cuerpos cetónicos (beta-hidroxibutirato (βHB), Acetoacetato (AcAc) y acetona) y ocurre en el periparto de vacas de leche. El origen primario de la enfermedad es el balance energético negativo (BEN), que puede ser desencadenado por el incremento excesivo de los requerimientos energéticos o la presentación de enfermedades posparto, resultando en la presentación de signos clínicos o disminución de la producción de leche. El objetivo de esta revisión consiste en describir, mediante un modelo, los procesos bioquímicos del rumen y los mecanismos fisiopatológicos, involucrados con incremento excesivo de los cuerpos cetónicos. En resumen, se realizó un modelo fisiológico uniendo literatura fragmentada, sobre la relación entre la función ruminal, hepática y la inducción de lipolisis e incremento de la actividad de Carnitil-Palmitoil transferasa-1 (CPT-1), cuyo resultado puede ser la producción excesiva de Acetil-CoA que, junto con la falta de propionato y oxalacetato (precursores de gluconeogénesis y ciclo de Krebs), dan lugar a la producción patológica de acetoacetato y beta-hidroxibutirato.
description_eng Bovine hyperketonemia or ketosis is a metabolic disorder characterized by high levels of ketone bodies (beta-hydroxybutyrate (βHB), Acetoacetate (AcAc), and acetone) in periparturient dairy cows. A Negative Energy Balance (NEB) is identified as the primary cause of the disease, which is triggered by the excessive increase of energy requirements or the presence of postpartum diseases, resulting in the appearance of clinical signs or decreased milk production. The purpose of this review is to describe the rumen’s biochemical Process and the physiopathological mechanisms involved in the excessive production of ketone bodies. After conducting a literature review, a physiological model was carried out in order to understand the relationship between the rumen and liver functions with lipolysis induction and increased CPT-1 activity. The above may result in the overproduction of Acetyl-CoA, which together, with the lack of propionate and oxaloacetate (gluconeogenesis and Krebs cycle precursors), leads to the pathological production of acetoacetate and beta-hydroxybutyrate.
author Huertas-Molina, Oscar Felípe
Londoño-Vásquez, Daniela
Olivera-Angel, Martha
author_facet Huertas-Molina, Oscar Felípe
Londoño-Vásquez, Daniela
Olivera-Angel, Martha
topicspa_str_mv balance energético negativo
cetosis
cuerpos cetónicos
vaca lechera
topic balance energético negativo
cetosis
cuerpos cetónicos
vaca lechera
negative energy balance
ketosis
ketone bodies
dairy cattle
topic_facet balance energético negativo
cetosis
cuerpos cetónicos
vaca lechera
negative energy balance
ketosis
ketone bodies
dairy cattle
citationvolume 23
citationissue 1
citationedition Núm. 1 , Año 2020 :Revista U.D.C.A Actualidad & Divulgación Científica. Enero-Junio
publisher Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
ispartofjournal Revista U.D.C.A Actualidad & Divulgación Científica
source https://revistas.udca.edu.co/index.php/ruadc/article/view/1304
language spa
format Article
rights https://creativecommons.org/licenses/by-nc-sa/4.0/
Oscar Felípe Huertas Molina, Daniela Londoño Vásquez, Martha Olivera Angel - 2020
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
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url https://revistas.udca.edu.co/index.php/ruadc/article/view/1304
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