Titulo:
Capacidades operativas de las definiciones de caso de COVID-19, para detectar pacientes diagnosticados por RT-PCR.
.
Sumario:
Objetivo. Las definiciones operativas de caso (D.O.C.) para el nuevo coronavirus (COVID-19) se construyeron para identificar personas potencialmente infectadas (PPI), en esta investigación medimos las capacidades operativas de sus componentes para discriminar infectados con COVID-19. Metodología. Con un diseño de corte transversal, utilizando datos contenidos en las fichas de notificación obligatorias y registros médicos de PPI de COVID-19 entre marzo-mayo/2020, atendidos por Cruz Roja IPS en Bogotá, se describieron las características sociodemográficas y clínicas, y se determinaron las capacidades operativas de las D.O.C. y sus componentes para discriminar pacientes diagnosticados con COVID-19 por RT-PCR. Resultados. Se identificaron 2174... Ver más
Guardado en:
0121-2133
2500-7181
26
2020-08-24
16
21
Aníbal A. Teherán - 2020
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http://purl.org/coar/access_right/c_abf2
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Capacidades operativas de las definiciones de caso de COVID-19, para detectar pacientes diagnosticados por RT-PCR. Operational capabilities of the COVID-19 case definitions to detect patients diagnosed by RT-PCR. Objetivo. Las definiciones operativas de caso (D.O.C.) para el nuevo coronavirus (COVID-19) se construyeron para identificar personas potencialmente infectadas (PPI), en esta investigación medimos las capacidades operativas de sus componentes para discriminar infectados con COVID-19. Metodología. Con un diseño de corte transversal, utilizando datos contenidos en las fichas de notificación obligatorias y registros médicos de PPI de COVID-19 entre marzo-mayo/2020, atendidos por Cruz Roja IPS en Bogotá, se describieron las características sociodemográficas y clínicas, y se determinaron las capacidades operativas de las D.O.C. y sus componentes para discriminar pacientes diagnosticados con COVID-19 por RT-PCR. Resultados. Se identificaron 2174 PPI de COVID-19, la prevalencia de infectados fue 14.7%, edad mediana 36 años, 57.7% mujeres, la mayoría presentó contacto estrecho, entre 12.7-21.1% de infectados eran trabajadores de la salud y 35.2% asintomáticos portadores. Los infectados presentaron con mayor frecuencia fiebre (32.8%; p: <0.001), y en general, 50-60% presentaron síntomas respiratorios. La sensibilidad de las manifestaciones clínicas fue menor al 50%. Los componentes de las D.O.C. más sensibles y específicos para discriminar infectados con COVID-19, respectivamente, fueron el antecedente de contacto estrecho y de viajes a áreas de transmisión local comunitaria en los últimos 14 días. Discusión. La baja sensibilidad de las manifestaciones clínicas para discriminar pacientes infectados con COVID-19, induce a actualizar las D.O.C. para mejorar la identificación de PPI. Adicionalmente, las medidas para prevenir la propagación en escenarios de atención de urgencias deben optimizarse y contemplar un tamizaje rutinario en salas No COVID. Objetive. The operational case definitions (OCD) for the new coronavirus (COVID-19) were constructed to identify potentially infected persons (PIP), in this investigation we measured the operational capabilities of its components to discriminate COVID-19 persons infected. Methodology. A cross-sectional design was performed using data contained in the mandatory notification records and PPI medical records of COVID-19 between March-May / 2020, attended by the IPS Red Cross in Bogota, the sociodemographic and clinical characteristics were described, and determined the operational capabilities of OCDs and its components to discriminate patients diagnosed with COVID-19 by RT-PCR. Results. 2174 PIPs of COVID-19 were identified, the prevalence of those infected was 14.7%, median age 36 years, 57.7% women, the majority presented close contact, between 12.7-21.1% of those infected were health workers and 35.2% were asymptomatic carriers. Those infected more frequently presented fever (32.8%; p: <0.001), and in general, 50-60% presented respiratory symptoms. The sensitivity of the clinical manifestations was less than 50%. The components of the OCD most sensitive and specific to discriminate infected with COVID-19, respectively, were the history of close contact and trips to areas of local community transmission in the last 14 days. Discussion. The low sensitivity of clinical manifestations to discriminate patients infected with COVID-19, leads to update the OCD to improve PIP identification. Additionally, measures to prevent the spread in emergency care settings should be optimized and include a routine screening in Non-COVID rooms. Teherán, Aníbal A. Camero Ramos, Gabriel Prado de la Guardia, Ronald Sanabria, Cindy Martínez, Víctor M. Pombo, Luis Miguel Ospina, María del Pilar Mora, Lyst E. Coronavirus COVID-19 operating capacities screening operational case definition Coronavirus COVID-19 capacidades operativas tamizaje definición operativa de caso 26 1 Artículo de revista Journal article 2020-08-24T17:19:24Z 2020-08-24T17:19:24Z 2020-08-24 application/pdf Fundación Universitaria Juan N. Corpas Revista Cuarzo 0121-2133 2500-7181 https://revistas.juanncorpas.edu.co/index.php/cuarzo/article/view/500 10.26752/cuarzo.v26.n1.500 https://doi.org/10.26752/cuarzo.v26.n1.500 spa https://creativecommons.org/licenses/by-nc-sa/4.0/ Aníbal A. Teherán - 2020 16 21 Laiton K, Villabona CJ, Usme JA, Franco C, Alvarez DA, Villabona LS, et al. Genomic epidemiology of SARS-CoV-2 in Colombia. medRxiv 2020.06.26.20135715; doi: https://doi.org/10.1101/2020.06.26.20135715. Teheran AA, Camero G, Prado R, Hernandez C, Herrera G, Pombo LM, et al. Epidemiological characterization of asymptomatic carriers of COVID-19 in Colombia. medRxiv 2020.06.18.20134734; doi: https://doi.org/10.1101/2020.06.18.20134734. World Health Organization. (2020). Novel Coronavirus (2019-nCoV): situation report, 1. World Health Organization. https://apps.who.int/iris/handle/10665/330760 Ramirez JD, Munoz M, Hernandez C, Florez C, Gomez S, Rico A, et al. Genetic diversity among SARS-CoV2 strains in South America may impact performance of Molecular detection. medRxiv 2020.06.18.20134759; doi: https://doi.org/10.1101/2020.06.18.20134759. Amariles P, Granados J, Ceballos M, Montoya CJ. COVID-19 in Colombia endpoints. Are we different, like Europe? Res Social Adm Pharm. 2020 Mar 31. doi: http://10.1016/j.sapharm.2020.03.013. Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W; on behalf of the Sheffield COVID-19 Genomics Group. Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell (2020), doi: https://doi.org/10.1016/j.cell.2020.06.043. Grant MC, Geoghegan L, Arbyn M, Mohammed Z, McGuinness L, Clarke EL, et al. The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries. PLoS One. 2020 Jun 23;15(6):e0234765. doi: 10.1371/journal.pone.0234765. Gao Z, Xu Y, Sun C, Wang X, Guo Y, Qiu S, et al. A Systematic Review of Asymptomatic Infections with COVID-19. J Microbiol Immunol Infect. 2020 May 15. doi: 10.1016/j.jmii.2020.05.001. Al-Sadeq DW, Nasrallah GK. The incidence of the novel coronavirus SARS-CoV-2 among asymptomatic patients: a systematic review. Int J Infect Dis. 2020 Jul 2:S1201-9712(20)30533-6. doi: 10.1016/j.ijid.2020.06.098. Kronbichler A, Kresse D, Yoon S, Lee KH, Effenberger M, Shin JI. Asymptomatic patients as a source of COVID-19 infections: A systematic review and meta-analysis. Int J Infect Dis. 2020 Jun 17:S1201-9712(20)30487-2. doi: 10.1016/j.ijid.2020.06.052. Instituto Nacional de Salud [en línea]. Colombia: 2020 [actualizada 11/07/2020]. Instructivo para la vigilancia en salud pública intensificada de infección respiratoria aguda asociada al nuevo coronavirus 2019 (COVID-19). Disponible en: https://www.ins.gov.co/Noticias/Coronavirus/Anexo_%20Instructivo%20Vigilancia%20COVID%20v11%2012052020.pdf Organización Panamericana de la Salud, Organización Mundial de la Salud. Módulos de principios de epidemiología para el control de enfermedades (MOPECE). 2da edición revisada. Washington DC: OPS; 2002, 36 p. Disponible en: https://www.paho.org/bra/index.php?option=com_D.O.Cman&view=download&alias=1269-modulos-principios-epidemiologia-para-control-enfermedades-mopece-unidad-1-presentacion-marco-conceptual-9&category_slug=informacao-e-analise-saude-096&Itemid=965 Tostmann A, Bradley J, Bousema T, Yiek WK, Holwerda M, Bleeker-Rovers C, et al. Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020. Euro Surveill. 2020 Apr;25(16):2000508. https://doi.org/10.2807/1560-7917.ES.2020.25.16.2000508. Struyf T, Deeks JJ, Dinnes J, Takwoingi Y, Davenport C, Leeflang MM, et al; Cochrane COVID-19 Diagnostic Test Accuracy Group. Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19 disease. Cochrane Database Syst Rev. 2020 Jul 7;7:CD013665. https://doi.org/10.1002/14651858.CD013665. Lovato A, de Filippis C. Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms. Ear Nose Throat J. 2020 Apr 13:145561320920762. https://doi.org/10.1177/0145561320920762. Wynants Laure, Van Calster Ben, Collins Gary S, Riley Richard D, Heinze Georg, Schuit Ewoud et al. Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal. BMJ. 2020;369:m1328 Chung HS, Lee DE, Kim JK, Yeo IH, Kim C, Park J, et al. Revised Triage and Surveillance Protocols for Temporary Emergency Department Closures in Tertiary Hospitals as a Response to COVID-19 Crisis in Daegu Metropolitan City. J Korean Med Sci. 2020 May 18;35(19):e189. https://doi.org/10.3346/jkms.2020.35.e189. Center for Disease Control and Prevention[online]. Unitted States of America: 2020. Standard Operating Procedure (SOP) for Triage of Suspected COVID-19 Patients in non-US Healthcare Settings: Early Identification and Prevention of Transmission during Triage. Available in: https://www.cdc.gov/coronavirus/2019-ncov/hcp/non-us-settings/sop-triage-prevent-transmission.html. Shi Y, Wang X, Liu G, Zhu Q, Wang J, Yu H, et al. A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China. Ann Transl Med. 2020 Mar;8(5):241. https://doi.org/10.21037/atm.2020.03.22 Ministerio de Salud y Protección Social [en línea]. Colombia: 2020. Colombia aumenta su capacidad hospitalaria para atención de covid-19. Disponible en: https://www.minsalud.gov.co/Paginas/Colombia-aumenta-su-capacidad-hospitalaria-para--atencion-de-covid-19.aspx Center for Disease Control and Prevention[online]. Unitted States of America: 2020[Last Updated May 13, 2020]. Symptoms of Coronavirus. Available in: https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html https://revistas.juanncorpas.edu.co/index.php/cuarzo/article/download/500/438 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/redcol/resource_type/ARTREF info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication |
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FUNDACION UNIVERSITARIA JUAN N. CORPAS |
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Colombia |
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Revista Cuarzo |
| title |
Capacidades operativas de las definiciones de caso de COVID-19, para detectar pacientes diagnosticados por RT-PCR. |
| spellingShingle |
Capacidades operativas de las definiciones de caso de COVID-19, para detectar pacientes diagnosticados por RT-PCR. Teherán, Aníbal A. Camero Ramos, Gabriel Prado de la Guardia, Ronald Sanabria, Cindy Martínez, Víctor M. Pombo, Luis Miguel Ospina, María del Pilar Mora, Lyst E. Coronavirus COVID-19 operating capacities screening operational case definition Coronavirus COVID-19 capacidades operativas tamizaje definición operativa de caso |
| title_short |
Capacidades operativas de las definiciones de caso de COVID-19, para detectar pacientes diagnosticados por RT-PCR. |
| title_full |
Capacidades operativas de las definiciones de caso de COVID-19, para detectar pacientes diagnosticados por RT-PCR. |
| title_fullStr |
Capacidades operativas de las definiciones de caso de COVID-19, para detectar pacientes diagnosticados por RT-PCR. |
| title_full_unstemmed |
Capacidades operativas de las definiciones de caso de COVID-19, para detectar pacientes diagnosticados por RT-PCR. |
| title_sort |
capacidades operativas de las definiciones de caso de covid-19, para detectar pacientes diagnosticados por rt-pcr. |
| title_eng |
Operational capabilities of the COVID-19 case definitions to detect patients diagnosed by RT-PCR. |
| description |
Objetivo. Las definiciones operativas de caso (D.O.C.) para el nuevo coronavirus (COVID-19) se construyeron para identificar personas potencialmente infectadas (PPI), en esta investigación medimos las capacidades operativas de sus componentes para discriminar infectados con COVID-19.
Metodología. Con un diseño de corte transversal, utilizando datos contenidos en las fichas de notificación obligatorias y registros médicos de PPI de COVID-19 entre marzo-mayo/2020, atendidos por Cruz Roja IPS en Bogotá, se describieron las características sociodemográficas y clínicas, y se determinaron las capacidades operativas de las D.O.C. y sus componentes para discriminar pacientes diagnosticados con COVID-19 por RT-PCR.
Resultados. Se identificaron 2174 PPI de COVID-19, la prevalencia de infectados fue 14.7%, edad mediana 36 años, 57.7% mujeres, la mayoría presentó contacto estrecho, entre 12.7-21.1% de infectados eran trabajadores de la salud y 35.2% asintomáticos portadores. Los infectados presentaron con mayor frecuencia fiebre (32.8%; p: <0.001), y en general, 50-60% presentaron síntomas respiratorios. La sensibilidad de las manifestaciones clínicas fue menor al 50%. Los componentes de las D.O.C. más sensibles y específicos para discriminar infectados con COVID-19, respectivamente, fueron el antecedente de contacto estrecho y de viajes a áreas de transmisión local comunitaria en los últimos 14 días.
Discusión. La baja sensibilidad de las manifestaciones clínicas para discriminar pacientes infectados con COVID-19, induce a actualizar las D.O.C. para mejorar la identificación de PPI. Adicionalmente, las medidas para prevenir la propagación en escenarios de atención de urgencias deben optimizarse y contemplar un tamizaje rutinario en salas No COVID.
|
| description_eng |
Objetive. The operational case definitions (OCD) for the new coronavirus (COVID-19) were constructed to identify potentially infected persons (PIP), in this investigation we measured the operational capabilities of its components to discriminate COVID-19 persons infected.
Methodology. A cross-sectional design was performed using data contained in the mandatory notification records and PPI medical records of COVID-19 between March-May / 2020, attended by the IPS Red Cross in Bogota, the sociodemographic and clinical characteristics were described, and determined the operational capabilities of OCDs and its components to discriminate patients diagnosed with COVID-19 by RT-PCR.
Results. 2174 PIPs of COVID-19 were identified, the prevalence of those infected was 14.7%, median age 36 years, 57.7% women, the majority presented close contact, between 12.7-21.1% of those infected were health workers and 35.2% were asymptomatic carriers. Those infected more frequently presented fever (32.8%; p: <0.001), and in general, 50-60% presented respiratory symptoms. The sensitivity of the clinical manifestations was less than 50%. The components of the OCD most sensitive and specific to discriminate infected with COVID-19, respectively, were the history of close contact and trips to areas of local community transmission in the last 14 days.
Discussion. The low sensitivity of clinical manifestations to discriminate patients infected with COVID-19, leads to update the OCD to improve PIP identification. Additionally, measures to prevent the spread in emergency care settings should be optimized and include a routine screening in Non-COVID rooms.
|
| author |
Teherán, Aníbal A. Camero Ramos, Gabriel Prado de la Guardia, Ronald Sanabria, Cindy Martínez, Víctor M. Pombo, Luis Miguel Ospina, María del Pilar Mora, Lyst E. |
| author_facet |
Teherán, Aníbal A. Camero Ramos, Gabriel Prado de la Guardia, Ronald Sanabria, Cindy Martínez, Víctor M. Pombo, Luis Miguel Ospina, María del Pilar Mora, Lyst E. |
| topic |
Coronavirus COVID-19 operating capacities screening operational case definition Coronavirus COVID-19 capacidades operativas tamizaje definición operativa de caso |
| topic_facet |
Coronavirus COVID-19 operating capacities screening operational case definition Coronavirus COVID-19 capacidades operativas tamizaje definición operativa de caso |
| topicspa_str_mv |
Coronavirus COVID-19 capacidades operativas tamizaje definición operativa de caso |
| citationvolume |
26 |
| citationissue |
1 |
| publisher |
Fundación Universitaria Juan N. Corpas |
| ispartofjournal |
Revista Cuarzo |
| source |
https://revistas.juanncorpas.edu.co/index.php/cuarzo/article/view/500 |
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spa |
| format |
Article |
| rights |
https://creativecommons.org/licenses/by-nc-sa/4.0/ Aníbal A. Teherán - 2020 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
| references |
Laiton K, Villabona CJ, Usme JA, Franco C, Alvarez DA, Villabona LS, et al. Genomic epidemiology of SARS-CoV-2 in Colombia. medRxiv 2020.06.26.20135715; doi: https://doi.org/10.1101/2020.06.26.20135715. Teheran AA, Camero G, Prado R, Hernandez C, Herrera G, Pombo LM, et al. Epidemiological characterization of asymptomatic carriers of COVID-19 in Colombia. medRxiv 2020.06.18.20134734; doi: https://doi.org/10.1101/2020.06.18.20134734. World Health Organization. (2020). Novel Coronavirus (2019-nCoV): situation report, 1. World Health Organization. https://apps.who.int/iris/handle/10665/330760 Ramirez JD, Munoz M, Hernandez C, Florez C, Gomez S, Rico A, et al. Genetic diversity among SARS-CoV2 strains in South America may impact performance of Molecular detection. medRxiv 2020.06.18.20134759; doi: https://doi.org/10.1101/2020.06.18.20134759. Amariles P, Granados J, Ceballos M, Montoya CJ. COVID-19 in Colombia endpoints. Are we different, like Europe? Res Social Adm Pharm. 2020 Mar 31. doi: http://10.1016/j.sapharm.2020.03.013. Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W; on behalf of the Sheffield COVID-19 Genomics Group. Tracking changes in SARS-CoV-2 Spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell (2020), doi: https://doi.org/10.1016/j.cell.2020.06.043. Grant MC, Geoghegan L, Arbyn M, Mohammed Z, McGuinness L, Clarke EL, et al. The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries. PLoS One. 2020 Jun 23;15(6):e0234765. doi: 10.1371/journal.pone.0234765. Gao Z, Xu Y, Sun C, Wang X, Guo Y, Qiu S, et al. A Systematic Review of Asymptomatic Infections with COVID-19. J Microbiol Immunol Infect. 2020 May 15. doi: 10.1016/j.jmii.2020.05.001. Al-Sadeq DW, Nasrallah GK. The incidence of the novel coronavirus SARS-CoV-2 among asymptomatic patients: a systematic review. Int J Infect Dis. 2020 Jul 2:S1201-9712(20)30533-6. doi: 10.1016/j.ijid.2020.06.098. Kronbichler A, Kresse D, Yoon S, Lee KH, Effenberger M, Shin JI. Asymptomatic patients as a source of COVID-19 infections: A systematic review and meta-analysis. Int J Infect Dis. 2020 Jun 17:S1201-9712(20)30487-2. doi: 10.1016/j.ijid.2020.06.052. Instituto Nacional de Salud [en línea]. Colombia: 2020 [actualizada 11/07/2020]. Instructivo para la vigilancia en salud pública intensificada de infección respiratoria aguda asociada al nuevo coronavirus 2019 (COVID-19). Disponible en: https://www.ins.gov.co/Noticias/Coronavirus/Anexo_%20Instructivo%20Vigilancia%20COVID%20v11%2012052020.pdf Organización Panamericana de la Salud, Organización Mundial de la Salud. Módulos de principios de epidemiología para el control de enfermedades (MOPECE). 2da edición revisada. Washington DC: OPS; 2002, 36 p. Disponible en: https://www.paho.org/bra/index.php?option=com_D.O.Cman&view=download&alias=1269-modulos-principios-epidemiologia-para-control-enfermedades-mopece-unidad-1-presentacion-marco-conceptual-9&category_slug=informacao-e-analise-saude-096&Itemid=965 Tostmann A, Bradley J, Bousema T, Yiek WK, Holwerda M, Bleeker-Rovers C, et al. Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020. Euro Surveill. 2020 Apr;25(16):2000508. https://doi.org/10.2807/1560-7917.ES.2020.25.16.2000508. Struyf T, Deeks JJ, Dinnes J, Takwoingi Y, Davenport C, Leeflang MM, et al; Cochrane COVID-19 Diagnostic Test Accuracy Group. Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19 disease. Cochrane Database Syst Rev. 2020 Jul 7;7:CD013665. https://doi.org/10.1002/14651858.CD013665. Lovato A, de Filippis C. Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms. Ear Nose Throat J. 2020 Apr 13:145561320920762. https://doi.org/10.1177/0145561320920762. Wynants Laure, Van Calster Ben, Collins Gary S, Riley Richard D, Heinze Georg, Schuit Ewoud et al. Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal. BMJ. 2020;369:m1328 Chung HS, Lee DE, Kim JK, Yeo IH, Kim C, Park J, et al. Revised Triage and Surveillance Protocols for Temporary Emergency Department Closures in Tertiary Hospitals as a Response to COVID-19 Crisis in Daegu Metropolitan City. J Korean Med Sci. 2020 May 18;35(19):e189. https://doi.org/10.3346/jkms.2020.35.e189. Center for Disease Control and Prevention[online]. Unitted States of America: 2020. Standard Operating Procedure (SOP) for Triage of Suspected COVID-19 Patients in non-US Healthcare Settings: Early Identification and Prevention of Transmission during Triage. Available in: https://www.cdc.gov/coronavirus/2019-ncov/hcp/non-us-settings/sop-triage-prevent-transmission.html. Shi Y, Wang X, Liu G, Zhu Q, Wang J, Yu H, et al. A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China. Ann Transl Med. 2020 Mar;8(5):241. https://doi.org/10.21037/atm.2020.03.22 Ministerio de Salud y Protección Social [en línea]. Colombia: 2020. Colombia aumenta su capacidad hospitalaria para atención de covid-19. Disponible en: https://www.minsalud.gov.co/Paginas/Colombia-aumenta-su-capacidad-hospitalaria-para--atencion-de-covid-19.aspx Center for Disease Control and Prevention[online]. Unitted States of America: 2020[Last Updated May 13, 2020]. Symptoms of Coronavirus. Available in: https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html |
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