Método 30-30 para mejorar la calidad de vida de los pacientes con cáncer en estadio II onco-exe trial
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Introducción: El cáncer es una de las enfermedades con mayor prevalencia, mortalidad e incapacidad en la actualidad. Se dice que 1 de cada 5 y 6 hombres y mujeres respectivamente en todo el mundo, desarrollaran cáncer durante su vida, y uno de cada 8 hombres y una de cada 11 mujeres mueren por esta enfermedad. Objetivo: Determinar si el entrenamiento HIIT en modalidad 30-30 mejora la calidad de vida de los pacientes con cáncer en estadio II. Materiales y métodos: Estudio experimental descriptivo con seguimiento longitudinal de cronológia prospectiva con una muestra de 275 pacientes (H:150 vs M:125) con cáncer en estadio II. Se identificaron factores de riesgo y además, prueba de esfuerzo, antropometría, calidad de vida, parámetros clínicos... Ver más
2011-7191
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2021-12-22
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Corporación Universitaria Iberoamericana - 2021
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Método 30-30 para mejorar la calidad de vida de los pacientes con cáncer en estadio II onco-exe trial 30-30 method to improve the quality of life of patients with stage II cancer onco-exe trial OF LIFE OF CANCER PATIENTS IN STAGE II. ONCO-EXE TRIAL Introducción: El cáncer es una de las enfermedades con mayor prevalencia, mortalidad e incapacidad en la actualidad. Se dice que 1 de cada 5 y 6 hombres y mujeres respectivamente en todo el mundo, desarrollaran cáncer durante su vida, y uno de cada 8 hombres y una de cada 11 mujeres mueren por esta enfermedad. Objetivo: Determinar si el entrenamiento HIIT en modalidad 30-30 mejora la calidad de vida de los pacientes con cáncer en estadio II. Materiales y métodos: Estudio experimental descriptivo con seguimiento longitudinal de cronológia prospectiva con una muestra de 275 pacientes (H:150 vs M:125) con cáncer en estadio II. Se identificaron factores de riesgo y además, prueba de esfuerzo, antropometría, calidad de vida, parámetros clínicos y hemodinámicos. Las pruebas se realizaron pre y post entrenamiento del método 30-30. Cada sesión se realizó de 70 minutos, 3 veces por semana durante 3 meses. Resultados: Este estudio contó con pacientes de cáncer de próstata, mama, colorrectal, cervico-uterino, tiroides, pulmón, estomago, hepático y entre otros. La edad promedio fue de 56±10 años. Los participantes presentaron cambios pos entrenamiento en el Vo2 (7.5±5.7 vs. 13.9±3.3 mL/kg-1/ min-1), frecuencia cardíaca máxima (156±12 vs. 175±14), fracción de eyección (40±4,8 vs 47±5,6), calidad de vida (108±14 vs 121±7,6) y fatiga asociada al cáncer (16,3±9,7 vs 5,5±4,9). Conclusiones: El método de entrenamiento 30-30 se mostró seguro y mejoró todas las variables evaluadas. De hecho, luego de este programa de entrenamiento aumentó la calidad de vida significativamente (< 0,05) de los participantes intervenidos. Trial Registration: NCT03915288. Introduction: Cancer is one of the diseases with the highest prevalence, mortality and disability at present. It is said that 1 out of 5 and 6 men and women, respectively, worldwide, will develop cancer during their lives, and one in 8 men and one in 11 women die from this disease. Objective: To determine whether HIIT training in 30-30 modality improves the quality of life of patients with stage II cancer. Materials and methods: Descriptive experimental study with longitudinal follow-up of prospective chronology with a sample of 275 patients (H:150 vs M:125) with stage II cancer. Risk factors were identified and, in addition, stress test, anthropometry, quality of life, clinical and hemodynamic parameters. The tests were done pre and post training of the 30-30 method. Each session was held for 70 minutes, 3 times a week for 3 months. Results: This study included patients with prostate, breast, colorectal, cervico-uterine, thyroid, lung, stomach, liver and others. Their average age was 56±10 years. Participants presented post-training changes in Vo2 (7.5±5.7 vs. 13.9±3.3 mL/kg-1/min-1), maximum heart rate (156±12 vs. 175±14), ejection fraction (40±4,8 vs 47±5.6), quality of life (108±14 vs 121±7.6) and fatigue associated with cancer (16.3±9.7 vs 5.5±4.9). Conclusions: The 30-30 training method was safe and improved all the variables evaluated. In fact, after this training program, the quality of life significantly increased (<0.05) of the participants who underwent surgery. Trial Registration: NCT03915288. Pereira Rodriguez, Javier Eliecer Peñaranda Florez, Devi Geesel Ricardo, Pereira Rodríguez Pedro, Pereira Rodríguez Leidy Laura, Barreto Castillo Karla Noelly, Santamaría Perez Neoplasia ejercicio aeróbico entrenamiento de alta intensidad fuerza Fisioterpia 15 1 Artículo de revista Journal article 2021-12-22T15:50:00Z 2021-12-22T15:50:00Z 2021-12-22 application/pdf Bogotá: Corporación Universitaria Iberoamericana Movimiento científico 2011-7191 2463-2236 https://revmovimientocientifico.ibero.edu.co/article/view/mct15101 10.33881/2011-7191.mct.15101 https://doi.org/10.33881/2011-7191.mct.15101 spa https://creativecommons.org/licenses/by-nc-sa/4.0 Corporación Universitaria Iberoamericana - 2021 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0. 1 9 Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., . . . Fumikazu, T. (3 de Marzo de 1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology. JNCI Journal of the National Cancer Institute, 85(5), 365-376. doi:10.1093/jnci/85.5.365 American Thoracic Society. (2002). ATS Statement: Guidelines for the Six-Minute Walk Test. American Journal of Respiratory and Critical Care Medicine, 166(1), 111–117. doi:10.1164/ajrccm.166.1.at1102 Ballesta, I., Rubio, J. Á., Ramos, D. J., Martínez, I., & Carrasco, M. (2019). Dosis de ejercicio interválico de alta intensidad en la rehabilitación cardiaca de la insuficiencia cardiaca y la enfermedad arterial coronaria: revisión sistemática y metanálisis. Revista Española de Cardiología, 72(3), 233-243. doi:10.1016/j.recesp.2018.02.017 Chan, D., Vieira, A., Aune, D., Bandera, E., Greenwood, D., McTiernan, A., . . . Norat, T. (2014). Body mass index and survival in women with breast cancer—systematic literature review and meta-analysis of 82 follow-up studies. Annals of Oncology, 25(10), 1901-1914. doi:10.1093/annonc/mdu042 Courneya, K. S., Segal, R. J., Mackey, J. R., Gelmon, K., Reid, R. D., Friedenreich, C. M., . . . McKenzie, D. C. (2007). Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. Journal of Clinical Oncology, 25(28), 4396–4404. doi:10.1200/JCO.2006.08.2024 Devin, J. L., Sax, A. T., Hughes, G. I., Jenkins, D. G., Aitken, J. F., Chambers, S. K., . . . Skinner, T. L. (2016). The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial. Journal of Cancer Survivorship, 10(3), 467–479. doi:10.1007/s11764-015-0490-7 Dolan, L. B., Campbell, K., Gelmon, K., Neil-Sztramko, S., Holmes, D., & McKenzie, D. C. (2016). Interval versus continuous aerobic exercise training in breast cancer survivors—a pilot RCT. Supportive Care in Cancer, 24(1), 119-127. doi:10.1007/s00520-015-2749-y Drigny, J., Gremeaux, V., Dupuy, O., Gayda, M., Bherer, L., Juneau, M., & Nigam, A. (2014). Effect of interval training on cognitive functioning and cerebral oxygenation in obese patients: A pilot study. Journal of Rehabilitation Medicine, 46(10), 1050–1054. doi:10.2340/16501977-1905 Enright, P., & Sherrill, D. (1998). Reference equations for the six-minute walk in healthy adults. American Journal of Respiratory and Critical Care Medicine, 158(5 Pt 1), 1384-1387. doi:10.1164/ajrccm.158.5.9710086 Fayers, P., Aaronson, N., Bjordal, K., Groenvold, M., Curran, D., & Bottomley, A. (2001). EORTC QLQ-C30 Scoring Manual (3 ed.). Brussels: European Organisation for Research and Treatment of Cancer. Obtenido de https://www.eortc.org/app/uploads/sites/2/2018/02/SCmanual.pdf Fett, C. A., Rezende, W. C., & Marchini, J. S. (2009). Exercício resistido vs jogging em fatores de risco metabólicos de mulheres com sobrepeso/obesas. Arquivos Brasileiros de Cardiologia, 93(5), 519–525. doi:https://doi.org/10.1590/S0066-782X2009001100013 Frisancho, A. R. (1993). Anthropometric standard for the assessment of growth and nutritional status. Chapter II: Methods and materials. 9-31. Ann Arbor: University of Michigan Press. doi:10.3998/mpub.12198 Gibala, M. J., Little, J. P., van Essen, M., Wilkin, G. P., Burgomaster, K. A., Safdar, A., . . . Tarnopolsky, M. A. (2006). Short-term sprint intervalversustraditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. The Journal of Physiology, 575(Pt 3), 901–911. doi:10.1113/jphysiol.2006.112094 Gillgrass, A., Gill, N., Babian, A., & Ashkar, A. A. (2014). The Absence or Overexpression of IL-15 Drastically Alters Breast Cancer Metastasis via Effects on NK Cells, CD4 T Cells, and Macrophages. The Journal of Immunology, 193(12), 6184–6191. doi:10.4049/jimmunol.1303175 Hashimoto, K., Sasajima, Y., Ando, M., Yonemori, K., Hirakawa, A., Furuta, K., . . . Fujiwara, Y. (2012). Immunohistochemical Profile for Unknown Primary Adenocarcinoma. PLoS ONE, 7(1), e31181. doi:10.1371/journal.pone.0031181 Jadus, M. R., Natividad, J., Mai, A., Ouyang, Y., Lambrecht, N., Szabo, S., . . . Dacosta-Iyer, M. G. (2012). Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention. Clinical and Developmental Immunology, 2012(160724). doi:10.1155/2012/160724 Jaureguizar, K. V., Vicente-Campos, D., Ruiz Bautista, L., Hernández de la Peña, C., Arriaza Gómez, M. J., Calero Rueda, M. J., & Fernández Mahillo, I. (2016). Effect of High-Intensity Interval Versus Continuous Exercise Training on Functional Capacity and Quality of Life in Patients With Coronary Artery Disease: A RANDOMIZED CLINICAL TRIAL. Journal of Cardiopulmonary Rehabilitation and Prevention, 36(2), 96-105. doi:10.1097/HCR.0000000000000156 Kodama, S., Saito, K., Tanaka, S., Maki, M., Yachi, Y., Asumi, M., . . . Sone, H. (2009). Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA, 301(19), 2024-2035. doi:10.1001/jama.2009.681 Kong, Z., Fan, X., Sun, S., Song, L., Shi, Q., & Nie, J. (2016). Comparison of High-Intensity Interval Training and Moderate-to-Vigorous Continuous Training for Cardiometabolic Health and Exercise Enjoyment in Obese Young Women: A Randomized Controlled Trial. PLoS One, 11(7), e0158589. doi:10.1371/journal.pone.0158589 McAuley, E., Blissmer, B., Katula, J., Duncan, T. E., & Mihalko, S. L. (2000). Physical activity, self-esteem, and self-efficacy relationships in older adults: A randomized controlled trial. Annals of Behavioral Medicine, 22(2), 131–139. doi:https://doi.org/10.1007/BF02895777 Mijwel, S., Backman, M., Bolam, K. A., Jervaeus, A., Sundberg, C. J., Margolin, S., . . . Wengström, Y. (2018). Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial. Breast Cancer Research and Treatment, 168(1), 79–93. doi:10.1007/s10549-017-4571-3 Mitrus, I., Bryndza, E., Sochanik, A., & Szala, S. (2012). Evolving models of tumor origin and progression. Tumor Biology, 33(4), 911-917. doi:10.1007/s13277-012-0389-0 Mugele, H., Freitag, N., Wilhelmi, J., Yang, Y., Cheng, S., Bloch, W., & Schumann, M. (2019). High-intensity interval training in the therapy and aftercare of cancer patients: a systematic review with meta-analysis. Journal of Cancer Survivorship, 13(2), 205-223. doi:10.1007/s11764-019-00743-3 Mutrie, N., Campbell, A. M., Whyte, F., McConnachie, A., Emslie, C., Lee, L., . . . Ritchie, D. (2007). Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial. BMJ, 334(7592), 517. doi:10.1136/bmj.39094.648553.AE Ouerghi, N., Selmi, O., Ben Khalifa, W., Ben Fradj, M. K., Feki, M., Kaabachi, N., & Bouassida, A. (2016). Effect of High-intensity Intermittent Training Program on Mood State in Overweight/Obese Young Men. Iran Journal of Public Health, 45(7), 951-952. Obtenido de https://pubmed.ncbi.nlm.nih.gov/27517005/ Perry, C. G., Heigenhauser, G. J., Bonen, A., & Spriet, L. L. (2008). High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle. Applied Physiology, Nutrition, and Metabolism, 33(6), 1112–1123. doi:10.1139/H08-097 Saanijoki, T., Tuominen, L., Tuulari, J. J., Nummenmaa, L., Arponen, E., Kalliokoski, K., & Hirvonen, J. (2018). Opioid Release after High-Intensity Interval Training in Healthy Human Subjects. Neuropsychopharmacology, 43(2), 246–254. doi:10.1038/npp.2017.148 Salazar-Martínez, E., Santalla, A., Naranjo Orellana, J., Strobl, J., Burtscher, M., & Menz, V. (2018). Influence of high-intensity interval training on ventilatory efficiency in trained athletes. Respiratory Physiology & Neurobiology, 250, 19–23. doi:10.1016/j.resp.2018.01.016 Sánchez, N. C. (2013). Conociendo y comprendiendo la célula cancerosa: Fisiopatología del cáncer. Revista Médica Clínica Las Condes, 24(4), 553-562. doi:10.1016/S0716-8640(13)70659-X Sánchez, R., Sierra, F. A., & Martín, E. (2015). ¿Qué es calidad de vida para un paciente con cáncer? Avances en Psicología Latinoamericana, 33(3), 371-385. doi:dx.doi.org/10.12804/apl33.03.2015.01 Siegel, R. L., Miller, K. D., & Jemal, A. (2019). Cancer statistics, 2019. CA: A Cancer Journal for Clinicians, 69(1), 7-34. doi:10.3322/caac.21551 Talanian, J. L., Galloway, S. D., Heigenhauser, G. J., Bonen, A., & Spriet, L. L. (2007). Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. Journal of Applied Physiology, 102(4), 1439–1447. doi:10.1152/japplphysiol.01098.2006 Thomas, R. J., Balady, G., Banka, G., Beckie, T. M., Chiu, J., Gokak, S., . . . Wang, T. Y. (2018). 2018 ACC/AHA Clinical Performance and Quality Measures for Cardiac Rehabilitation: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Journal of the American College of Cardiology, 71(16), 1814-1837. doi:10.1016/j.jacc.2018.01.004 Thompson, W. (2018). Worldwide survey of fitness trends for 2019. ACSMʼs Health & Fitness Journal, 22(6), 10-17. doi:10.1249/FIT.0000000000000438 Thum, J. S., Parsons, G., Whittle, T., & Astorino, T. A. (2017). High-Intensity Interval Training Elicits Higher Enjoyment than Moderate Intensity Continuous Exercise. Plos One, 12(1), e0166299. doi:10.1371/journal.pone.0166299 Valent, P., Bonnet, D., De Maria, R., Lapidot, T., Copland, M., Melo, J. V., . . . Eaves, C. (2012). Cancer stem cell definitions and terminology: the devil is in the details. Nature Reviews Cancer, 12(11), 767–775. doi:10.1038/nrc3368 Wahid, A., Manek, N., Nichols, M., Kelly, P., Foster, C., Webster, P., . . . Scarborough, P. (2016). Quantifying the Association Between Physical Activity and Cardiovascular Disease and Diabetes: A Systematic Review and Meta-Analysis. Journal of the American Heart Association, 5(9), e002495. doi:10.1161/JAHA.115.002495 Yellen, S. B., Cella, D. F., Webster, K., Blendowski, C., & Kaplan, E. (1997). Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. Journal of Pain and Symptom Management, 13(2), 63-74. doi:10.1016/s0885-3924(96)00274-6 https://revmovimientocientifico.ibero.edu.co/article/download/mct15101/1738 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/redcol/resource_type/ARTREF info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication |
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title |
Método 30-30 para mejorar la calidad de vida de los pacientes con cáncer en estadio II onco-exe trial |
spellingShingle |
Método 30-30 para mejorar la calidad de vida de los pacientes con cáncer en estadio II onco-exe trial Pereira Rodriguez, Javier Eliecer Peñaranda Florez, Devi Geesel Ricardo, Pereira Rodríguez Pedro, Pereira Rodríguez Leidy Laura, Barreto Castillo Karla Noelly, Santamaría Perez Neoplasia ejercicio aeróbico entrenamiento de alta intensidad fuerza Fisioterpia |
title_short |
Método 30-30 para mejorar la calidad de vida de los pacientes con cáncer en estadio II onco-exe trial |
title_full |
Método 30-30 para mejorar la calidad de vida de los pacientes con cáncer en estadio II onco-exe trial |
title_fullStr |
Método 30-30 para mejorar la calidad de vida de los pacientes con cáncer en estadio II onco-exe trial |
title_full_unstemmed |
Método 30-30 para mejorar la calidad de vida de los pacientes con cáncer en estadio II onco-exe trial |
title_sort |
método 30-30 para mejorar la calidad de vida de los pacientes con cáncer en estadio ii onco-exe trial |
title_eng |
30-30 method to improve the quality of life of patients with stage II cancer onco-exe trial OF LIFE OF CANCER PATIENTS IN STAGE II. ONCO-EXE TRIAL |
description |
Introducción: El cáncer es una de las enfermedades con mayor prevalencia, mortalidad e incapacidad en la actualidad. Se dice que 1 de cada 5 y 6 hombres y mujeres respectivamente en todo el mundo, desarrollaran cáncer durante su vida, y uno de cada 8 hombres y una de cada 11 mujeres mueren por esta enfermedad.
Objetivo: Determinar si el entrenamiento HIIT en modalidad 30-30 mejora la calidad de vida de los pacientes con cáncer en estadio II.
Materiales y métodos: Estudio experimental descriptivo con seguimiento longitudinal de cronológia prospectiva con una muestra de 275 pacientes (H:150 vs M:125) con cáncer en estadio II. Se identificaron factores de riesgo y además, prueba de esfuerzo, antropometría, calidad de vida, parámetros clínicos y hemodinámicos. Las pruebas se realizaron pre y post entrenamiento del método 30-30. Cada sesión se realizó de 70 minutos, 3 veces por semana durante 3 meses.
Resultados: Este estudio contó con pacientes de cáncer de próstata, mama, colorrectal, cervico-uterino, tiroides, pulmón, estomago, hepático y entre otros. La edad promedio fue de 56±10 años. Los participantes presentaron cambios pos entrenamiento en el Vo2 (7.5±5.7 vs. 13.9±3.3 mL/kg-1/ min-1), frecuencia cardíaca máxima (156±12 vs. 175±14), fracción de eyección (40±4,8 vs 47±5,6), calidad de vida (108±14 vs 121±7,6) y fatiga asociada al cáncer (16,3±9,7 vs 5,5±4,9).
Conclusiones: El método de entrenamiento 30-30 se mostró seguro y mejoró todas las variables evaluadas. De hecho, luego de este programa de entrenamiento aumentó la calidad de vida significativamente (< 0,05) de los participantes intervenidos.
Trial Registration: NCT03915288.
|
description_eng |
Introduction: Cancer is one of the diseases with the highest prevalence, mortality and disability at present. It is said that 1 out of 5 and 6 men and women, respectively, worldwide, will develop cancer during their lives, and one in 8 men and one in 11 women die from this disease.
Objective: To determine whether HIIT training in 30-30 modality improves the quality of life of patients with stage II cancer.
Materials and methods: Descriptive experimental study with longitudinal follow-up of prospective chronology with a sample of 275 patients (H:150 vs M:125) with stage II cancer. Risk factors were identified and, in addition, stress test, anthropometry, quality of life, clinical and hemodynamic parameters. The tests were done pre and post training of the 30-30 method. Each session was held for 70 minutes, 3 times a week for 3 months.
Results: This study included patients with prostate, breast, colorectal, cervico-uterine, thyroid, lung, stomach, liver and others. Their average age was 56±10 years. Participants presented post-training changes in Vo2 (7.5±5.7 vs. 13.9±3.3 mL/kg-1/min-1), maximum heart rate (156±12 vs. 175±14), ejection fraction (40±4,8 vs 47±5.6), quality of life (108±14 vs 121±7.6) and fatigue associated with cancer (16.3±9.7 vs 5.5±4.9).
Conclusions: The 30-30 training method was safe and improved all the variables evaluated. In fact, after this training program, the quality of life significantly increased (<0.05) of the participants who underwent surgery.
Trial Registration: NCT03915288.
|
author |
Pereira Rodriguez, Javier Eliecer Peñaranda Florez, Devi Geesel Ricardo, Pereira Rodríguez Pedro, Pereira Rodríguez Leidy Laura, Barreto Castillo Karla Noelly, Santamaría Perez |
author_facet |
Pereira Rodriguez, Javier Eliecer Peñaranda Florez, Devi Geesel Ricardo, Pereira Rodríguez Pedro, Pereira Rodríguez Leidy Laura, Barreto Castillo Karla Noelly, Santamaría Perez |
topicspa_str_mv |
Neoplasia ejercicio aeróbico entrenamiento de alta intensidad fuerza Fisioterpia |
topic |
Neoplasia ejercicio aeróbico entrenamiento de alta intensidad fuerza Fisioterpia |
topic_facet |
Neoplasia ejercicio aeróbico entrenamiento de alta intensidad fuerza Fisioterpia |
citationvolume |
15 |
citationissue |
1 |
publisher |
Bogotá: Corporación Universitaria Iberoamericana |
ispartofjournal |
Movimiento científico |
source |
https://revmovimientocientifico.ibero.edu.co/article/view/mct15101 |
language |
spa |
format |
Article |
rights |
https://creativecommons.org/licenses/by-nc-sa/4.0 Corporación Universitaria Iberoamericana - 2021 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0. info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
references |
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., . . . Fumikazu, T. (3 de Marzo de 1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology. JNCI Journal of the National Cancer Institute, 85(5), 365-376. doi:10.1093/jnci/85.5.365 American Thoracic Society. (2002). ATS Statement: Guidelines for the Six-Minute Walk Test. American Journal of Respiratory and Critical Care Medicine, 166(1), 111–117. doi:10.1164/ajrccm.166.1.at1102 Ballesta, I., Rubio, J. Á., Ramos, D. J., Martínez, I., & Carrasco, M. (2019). Dosis de ejercicio interválico de alta intensidad en la rehabilitación cardiaca de la insuficiencia cardiaca y la enfermedad arterial coronaria: revisión sistemática y metanálisis. Revista Española de Cardiología, 72(3), 233-243. doi:10.1016/j.recesp.2018.02.017 Chan, D., Vieira, A., Aune, D., Bandera, E., Greenwood, D., McTiernan, A., . . . Norat, T. 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