Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica
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En este artículo se realiza una revisión bibliográfica de algunas metodologías del diseño de experimentos, enfocándose en su función y relevancia dentro de los experimentos con materiales, donde se resalta la importancia de los diseños de experimentos dentro de la investigación usando ejemplos de estrategias metodológicas, en primer lugar se realizó una revisión que permitiera introducir el concepto de diseño de experimentos, como este fue concebido, sus principios y su relación con la investigación, se incluyen los elementos principales de los cuales se compone un diseño de experimentos, y algunos supuestos a tener en cuenta en el momento de aplicar un diseño experimental en la investigación. Además, se muestran diferentes metodologías uti... Ver más
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Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica Statistical metodologies used in experimentation with polymeric materials: a bibliographic review En este artículo se realiza una revisión bibliográfica de algunas metodologías del diseño de experimentos, enfocándose en su función y relevancia dentro de los experimentos con materiales, donde se resalta la importancia de los diseños de experimentos dentro de la investigación usando ejemplos de estrategias metodológicas, en primer lugar se realizó una revisión que permitiera introducir el concepto de diseño de experimentos, como este fue concebido, sus principios y su relación con la investigación, se incluyen los elementos principales de los cuales se compone un diseño de experimentos, y algunos supuestos a tener en cuenta en el momento de aplicar un diseño experimental en la investigación. Además, se muestran diferentes metodologías utilizas por algunos autores asociadas a los experimentos, se mencionan diferencias entre cada una de ellas y por qué emplearlas de acuerdo con la necesidad del experimento. Luego, se muestran distintos ejemplos de diseño de experimentos usadas en diferentes artículos de investigación enfocados en materiales poliméricos, en estos ejemplos se resaltan las distintas variables del experimento, cuál era el propósito de la investigación y porque se decantaron por el diseño de experimentos que mencionan. Por último, después de realizar la revisión bibliográfica se encontró que en la mayoría de los diseños experimentales aplicado al campo de la experimentación permite optimizar los recursos sin necesidad de realizar una gran cantidad de intentos, de hecho, dependiendo del tipo de experimento será factible elegir un diseño que se acomode a las necesidades de los investigadores, de acuerdo con los objetivos planteados en el experimento. In this article, a bibliographical review of some methodologies of design of experiments is carried out, focusing on its function and relevance within the experiments, where the importance of the designs of experiments within the investigation is highlighted using examples of the strategies and designs of experiments. In the first place, a review was carried out that would allow the introduction of the concept of design of experiments, how it was conceived, its principles and its relationship with the investigation, including the main elements of which designs of experiments are composed, and some assumptions to be considered at the time of apply an experimental design in research are included. In addition, different methodologies used by some authors in experiments are shown, what they are and a basic notion of the different methodologies used in the research, focusing on the differences between each one of them and why to use them according to the need of the experiment, then from this, different examples of the different experimental design methodologies used in research articles focused on polymeric materials were carried out, in these examples the different variables of the experiment were stood up, what was the purpose of the investigation and why they opted for the design of experiments they mention. Finally, after carrying out the bibliographical review, it was found that in most of the experimental design applied to the field of experimentation, it allows optimizing the resources without the need to make many attempts. In fact, depending on the type of experiment, it will be feasible to choose a design that is accommodate the needs of the researchers, according to the objectives set in the experiment. Correa Álvarez, Cristian David Aguirre Poblador, Jose Felipe Baena Peréz , Libia María design of experiments methods testing experiments design variability factorial design factor optimization materials Diseño de experimentos métodos ensayos experimentos diseño variabilidad Diseño factorial factores optimización materiales 20 40 Núm. 40 , Año 2023 : Tabla de contenido Revista EIA No. 40 Artículo de revista Journal article 2023-12-19 00:00:00 2023-12-19 00:00:00 2023-12-19 application/pdf Fondo Editorial EIA - Universidad EIA Revista EIA 1794-1237 2463-0950 https://revistas.eia.edu.co/index.php/reveia/article/view/1658 10.24050/reia.v20i40.1658 https://doi.org/10.24050/reia.v20i40.1658 spa https://creativecommons.org/licenses/by-nc-nd/4.0 Revista EIA - 2023 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0. 4004 pp. 1 17 Atuanya, C. U.; Aigbodion, V. S.; Nwigbo, S. C. (2014). Experimental study of the thermal and wear properties of recycled polyethylene/breadfruit seed hull ash particulate composites. Materials and Design, 53, pp. 65–73. https://doi.org/10.1016/j.matdes.2013.06.057 Atuanya, C. U.; Aigbodion, V. S.; Obiorah, S. O.; Kchaou, M.; Elleuch, R. (2016). Empirical models for estimating the mechanical and morphological properties of recycled low density polyethylene/snail shell bio-composites. Journal of the Association of Arab Universities for Basic and Applied Sciences, 21, pp. 45–52. https://doi.org/10.1016/j.jaubas.2015.01.001 Babbie, E. (2000). Fundamentos de la Investigacion Social. Cengage Learning Latin Am. http://books.google.es/books?id=1_yyPqkoqMIC. Barad, M. (2018). Strategies and techniques for quality and flexibility. SpringerBriefs in Applied Sciences and Technology. Cham: Springer. https://doi.org/https://doi.org/10.1007/978-3-319-68400-0 Berger, P. D.; Maurer, R. E.; Celli, G. B. (2017). Experimental design: With applications in management, engineering, and the sciences, 2a ed., Suiza, Springer Cham. https://doi.org/10.1007/978-3-319-64583-4 Charbonné, C.; Dhuitte, M. L.; Bouziane, K.; Chamoret, D.; Candusso, D.; Meyer, Y. (2021). Design of experiments on the effects of linear and hyperelastic constitutive models and geometric parameters on polymer electrolyte fuel cell mechanical and electrical behaviour. International Journal of Hydrogen Energy, 46(26), 13775–13790. https://doi.org/10.1016/j.ijhydene.2021.02.122 Coleman, D. E.; Montgomery, D. C. (1993). A Systematic Approach to Planning for a Designed Industrial Experiment. Technometrics, 35(1), 1. https://doi.org/10.2307/1269280 Colwell, M.; Frith, R. (2021). Utilising the scientific method to demonstrate that slender beam/column behaviour is the dominant behavioural mechanism leading to roof/rib failure. International Journal of Mining Science and Technology, 31(5), 867–887. https://doi.org/10.1016/j.ijmst.2021.07.009 Del Vecchio, R. J. (2007). Design of Experiments. Handbook of Vinyl Formulating, 2a ed., Grossman, F., pp. 515–527. https://doi.org/10.1002/9780470253595.ch22 Doebelin, E. (2010). Introduction to Statistical Design of Experiments. In: Instrumentation Design Studies. CRC Press. https://doi.org/10.1201/9781439819487 Dong, J.; Mandenius, C. F.; Lübberstedt, M.; Urbaniak, T.; Nüssler, A. K. N.; Knobeloch, D.; Gerlach, J. C.; Zeilinger, K. (2008). Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology. Cytotechnology, 57(3), pp. 251–261. https://doi.org/10.1007/s10616-008-9168-6 Eckes, G. (2003). Six Sigma for Everyone, Hoboken, John Wiley & Sons, Inc. Farotti, E.; Natalini, M. (2018). Injection molding. Influence of process parameters on mechanical properties of polypropylene polymer. A first study. Procedia Structural Integrity, 8, pp. 256–264. https://doi.org/10.1016/j.prostr.2017.12.027 Gomes, F. P. C.; Thompson, M. R. (2018). Nondestructive evaluation of sintering and degradation for rotational molded polyethylene. Polymer Degradation and Stability, 157, pp. 34–43. https://doi.org/10.1016/j.polymdegradstab.2018.09.013 Gupta, S.; Uday, V.; Raghuwanshi, A. S.; Chowkshey, S.; Das, S. N.; Suresh, S. (2013). Simulation of Blow Molding Using Ansys Polyflow. APCBEE Procedia, 5, pp. 468–473. https://doi.org/10.1016/j.apcbee.2013.05.079 Jankovic, A.; Chaudhary, G.; Goia, F. (2021). Designing the design of experiments (DOE) – An investigation on the influence of different factorial designs on the characterization of complex systems. Energy and Buildings, 250, 111298. https://doi.org/10.1016/j.enbuild.2021.111298 Johnson, R.; Miller, I.; Freund, J. (2018). Miller & Freund’s probability and statistics for engineers, 9na ed., Madison, Pearson Education. Kumar, S.; Singh, R.; Singh, T. P.; Batish, A. (2019). On process capability comparison of hybrid and multi blend PLA matrix composite: Magnetic and surface properties viewpoint. Materials Today: Proceedings, 28, pp. 521–525. https://doi.org/10.1016/j.matpr.2019.12.212 Kwiatkowski, D.; Modławski, M.; Jaruga, T. (2017). Design of Flash Pocket Inserts in an Extrusion Blow Mould Based on the Results of Numerical Simulations. Procedia Engineering, 177, pp. 127–134. https://doi.org/10.1016/j.proeng.2017.02.200 Lee, B. C. Y.; Mahtab, M. S.; Neo, T. H.; Farooqi, I. H.; Khursheed, A. (2022). A comprehensive review of Design of experiment (DOE) for water and wastewater treatment application - Key concepts, methodology and contextualized application. Journal of Water Process Engineering, 47(December 2021), 102673. https://doi.org/10.1016/j.jwpe.2022.102673 Lewis, S. M.; De la Salle, B. (2008). Control de calidad, Dacie y Lewis, Hematología Práctica (10 ed.), pp. 561-572. https://doi.org/10.1016/b978-84-8086-229-5.50026-6 Lontos, A.; Gregoriou, A. (2019). The effect of the deformation rate on the wall thickness of 1.5LT PET bottle during ISBM (Injection Stretch Blow Molding) process. Procedia CIRP, 81, pp. 1307–1312. https://doi.org/10.1016/j.procir.2019.04.018 Machery, E. (2020). What is a Replication? Philosophy of Science, 87(4), pp. 545-567. https://doi.org/10.1086/709701. Montgomery, D. C. (2013). Design and Analysis of Experiments, 8va ed., Arizona State University, John Wiley & Sons. Nardi, D.; Sinke, J. (2021). Design analysis for thermoforming of thermoplastic composites: prediction and machine learning-based optimization. Composites Part C: Open Access, 5, 100126. https://doi.org/10.1016/j.jcomc.2021.100126 Nelles, O. (2020). Nonlinear System Identification. From Classical Approaches to Neural Networks, Fuzzy Models, and Gaussian Processes, Suiza, Springer: Cham. https://doi.org/10.1007/978-3-030-47439-3 Niedz, R. P.; Evens, T. J. (2016). Design of experiments (DOE)—history, concepts, and relevance to in vitro culture. In Vitro Cellular and Developmental Biology - Plant, 52(6), pp. 547–562. https://doi.org/10.1007/s11627-016-9786-1 Nieschlag, J.; Eisenhardt, P.; Coutandin, S.; Fleischer, J. (2021). Numerical design of rotationally molded composite tie rods. Composite Structures, 278, 114687. https://doi.org/10.1016/j.compstruct.2021.114687 Pakdil, F. (2020). Six Sigma for Students. A Problem-Solving Methodology, Suiza, Springer International Publishing. https://doi.org/10.1007/978-3-030-40709-4 Ramkumar, P. L.; Kulkarni, D. M.; Chaudhari, V. V. (2019). Fracture toughness of LLDPE parts using rotational moulding technology. International Journal of Materials and Product Technology, 58(4), pp. 305–322. https://doi.org/10.1504/IJMPT.2019.100003 Román-Ramírez, L. A.; Marco, J. (2022). Design of experiments applied to lithium-ion batteries: A literature review. Applied Energy, 320. https://doi.org/10.1016/j.apenergy.2022.119305 Saeedabadi, K.; Tosello, G.; Calaon, M. (2022). Optimization of injection molded polymer lab-on-a-chip for acoustic blood plasma separation using virtual design of experiment. Procedia CIRP, 107, pp. 40–45. https://doi.org/10.1016/j.procir.2022.04.007 Santa, A. C.; Tamayo, J. A.; Correa, C. D.; Gómez, M. A.; Castaño, J. G.; Baena, L. M. (2022). Atmospheric corrosion maps as a tool for designing and maintaining building materials: A review. Heliyon 8(9). https://doi.org/10.1016/j.heliyon.2022.e10438 Schiefer, H.; Schiefer, F. (2021). Statistics for Engineers, Wiesbaden, Springer Fachmedien Wiesbaden. https://doi.org/10.1007/978-3-658-32397-4 Tumova, O.; Kupka, L.; Netolicky, P. (2018). Design of Experiments approach and its application in the evaluation of experiments. 2018 International Conference on Diagnostics in Electrical Engineering, Diagnostika 2018, pp. 15–18. https://doi.org/10.1109/DIAGNOSTIKA.2018.8526104 Vieira, L. W.; Marques, A. D.; Schneider, P. S.; José da Silva Neto, A.; Viana, F. A. C.; Abdel-Jawad, M.; Hunt, J. D.; Siluk, J. C. M. (2021). Methodology for ranking controllable parameters to enhance operation of a steam generator with a combined Artificial Neural Network and Design of Experiments approach. Energy and AI, 3, 100040. https://doi.org/10.1016/j.egyai.2020.100040 Wu, C. F. J.; Hamada, M. (2021). Experiments: Planning, Analysis, and Optimization. In Journal of Engineering Management and Competitiveness 10(1). https://doi.org/10.1002/9781119470007 Xin, L. L.; Sharif, S.; Saad, R. M. (2015). Gas-assisted Injection Molding: Case Study on Process Optimization of CD-Rom Tray Manufacturing. In Procedia Manufacturing, 2, pp. 538–542. https://doi.org/10.1016/j.promfg.2015.07.093 Yuce, B. E.; Nielsen, P. V.; Wargocki, P. (2022). Numerical Analyses of Ventilation Performance in Buildings Using CFD with ANOVA, Taguchi and GRA. Ssrn, 225, 109587. https://doi.org/10.1016/j.buildenv.2022.109587 https://revistas.eia.edu.co/index.php/reveia/article/download/1658/1555 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_2df8fbb1 http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication |
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UNIVERSIDAD EIA |
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Colombia |
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Revista EIA |
title |
Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica |
spellingShingle |
Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica Correa Álvarez, Cristian David Aguirre Poblador, Jose Felipe Baena Peréz , Libia María design of experiments methods testing experiments design variability factorial design factor optimization materials Diseño de experimentos métodos ensayos experimentos diseño variabilidad Diseño factorial factores optimización materiales |
title_short |
Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica |
title_full |
Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica |
title_fullStr |
Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica |
title_full_unstemmed |
Metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica |
title_sort |
metodologías estadísticas utilizadas en la experimentación con materiales poliméricos: una revisión bibliográfica |
title_eng |
Statistical metodologies used in experimentation with polymeric materials: a bibliographic review |
description |
En este artículo se realiza una revisión bibliográfica de algunas metodologías del diseño de experimentos, enfocándose en su función y relevancia dentro de los experimentos con materiales, donde se resalta la importancia de los diseños de experimentos dentro de la investigación usando ejemplos de estrategias metodológicas, en primer lugar se realizó una revisión que permitiera introducir el concepto de diseño de experimentos, como este fue concebido, sus principios y su relación con la investigación, se incluyen los elementos principales de los cuales se compone un diseño de experimentos, y algunos supuestos a tener en cuenta en el momento de aplicar un diseño experimental en la investigación. Además, se muestran diferentes metodologías utilizas por algunos autores asociadas a los experimentos, se mencionan diferencias entre cada una de ellas y por qué emplearlas de acuerdo con la necesidad del experimento. Luego, se muestran distintos ejemplos de diseño de experimentos usadas en diferentes artículos de investigación enfocados en materiales poliméricos, en estos ejemplos se resaltan las distintas variables del experimento, cuál era el propósito de la investigación y porque se decantaron por el diseño de experimentos que mencionan. Por último, después de realizar la revisión bibliográfica se encontró que en la mayoría de los diseños experimentales aplicado al campo de la experimentación permite optimizar los recursos sin necesidad de realizar una gran cantidad de intentos, de hecho, dependiendo del tipo de experimento será factible elegir un diseño que se acomode a las necesidades de los investigadores, de acuerdo con los objetivos planteados en el experimento.
|
description_eng |
In this article, a bibliographical review of some methodologies of design of experiments is carried out, focusing on its function and relevance within the experiments, where the importance of the designs of experiments within the investigation is highlighted using examples of the strategies and designs of experiments. In the first place, a review was carried out that would allow the introduction of the concept of design of experiments, how it was conceived, its principles and its relationship with the investigation, including the main elements of which designs of experiments are composed, and some assumptions to be considered at the time of apply an experimental design in research are included. In addition, different methodologies used by some authors in experiments are shown, what they are and a basic notion of the different methodologies used in the research, focusing on the differences between each one of them and why to use them according to the need of the experiment, then from this, different examples of the different experimental design methodologies used in research articles focused on polymeric materials were carried out, in these examples the different variables of the experiment were stood up, what was the purpose of the investigation and why they opted for the design of experiments they mention. Finally, after carrying out the bibliographical review, it was found that in most of the experimental design applied to the field of experimentation, it allows optimizing the resources without the need to make many attempts. In fact, depending on the type of experiment, it will be feasible to choose a design that is accommodate the needs of the researchers, according to the objectives set in the experiment.
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author |
Correa Álvarez, Cristian David Aguirre Poblador, Jose Felipe Baena Peréz , Libia María |
author_facet |
Correa Álvarez, Cristian David Aguirre Poblador, Jose Felipe Baena Peréz , Libia María |
topic |
design of experiments methods testing experiments design variability factorial design factor optimization materials Diseño de experimentos métodos ensayos experimentos diseño variabilidad Diseño factorial factores optimización materiales |
topic_facet |
design of experiments methods testing experiments design variability factorial design factor optimization materials Diseño de experimentos métodos ensayos experimentos diseño variabilidad Diseño factorial factores optimización materiales |
topicspa_str_mv |
Diseño de experimentos métodos ensayos experimentos diseño variabilidad Diseño factorial factores optimización materiales |
citationvolume |
20 |
citationissue |
40 |
citationedition |
Núm. 40 , Año 2023 : Tabla de contenido Revista EIA No. 40 |
publisher |
Fondo Editorial EIA - Universidad EIA |
ispartofjournal |
Revista EIA |
source |
https://revistas.eia.edu.co/index.php/reveia/article/view/1658 |
language |
spa |
format |
Article |
rights |
https://creativecommons.org/licenses/by-nc-nd/4.0 Revista EIA - 2023 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0. info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
references |
Atuanya, C. U.; Aigbodion, V. S.; Nwigbo, S. C. (2014). Experimental study of the thermal and wear properties of recycled polyethylene/breadfruit seed hull ash particulate composites. Materials and Design, 53, pp. 65–73. https://doi.org/10.1016/j.matdes.2013.06.057 Atuanya, C. U.; Aigbodion, V. S.; Obiorah, S. O.; Kchaou, M.; Elleuch, R. (2016). Empirical models for estimating the mechanical and morphological properties of recycled low density polyethylene/snail shell bio-composites. Journal of the Association of Arab Universities for Basic and Applied Sciences, 21, pp. 45–52. https://doi.org/10.1016/j.jaubas.2015.01.001 Babbie, E. (2000). Fundamentos de la Investigacion Social. Cengage Learning Latin Am. http://books.google.es/books?id=1_yyPqkoqMIC. Barad, M. (2018). Strategies and techniques for quality and flexibility. SpringerBriefs in Applied Sciences and Technology. Cham: Springer. https://doi.org/https://doi.org/10.1007/978-3-319-68400-0 Berger, P. D.; Maurer, R. E.; Celli, G. B. (2017). Experimental design: With applications in management, engineering, and the sciences, 2a ed., Suiza, Springer Cham. https://doi.org/10.1007/978-3-319-64583-4 Charbonné, C.; Dhuitte, M. L.; Bouziane, K.; Chamoret, D.; Candusso, D.; Meyer, Y. (2021). Design of experiments on the effects of linear and hyperelastic constitutive models and geometric parameters on polymer electrolyte fuel cell mechanical and electrical behaviour. International Journal of Hydrogen Energy, 46(26), 13775–13790. https://doi.org/10.1016/j.ijhydene.2021.02.122 Coleman, D. E.; Montgomery, D. C. (1993). A Systematic Approach to Planning for a Designed Industrial Experiment. Technometrics, 35(1), 1. https://doi.org/10.2307/1269280 Colwell, M.; Frith, R. (2021). Utilising the scientific method to demonstrate that slender beam/column behaviour is the dominant behavioural mechanism leading to roof/rib failure. International Journal of Mining Science and Technology, 31(5), 867–887. https://doi.org/10.1016/j.ijmst.2021.07.009 Del Vecchio, R. J. (2007). Design of Experiments. Handbook of Vinyl Formulating, 2a ed., Grossman, F., pp. 515–527. https://doi.org/10.1002/9780470253595.ch22 Doebelin, E. (2010). Introduction to Statistical Design of Experiments. In: Instrumentation Design Studies. CRC Press. https://doi.org/10.1201/9781439819487 Dong, J.; Mandenius, C. F.; Lübberstedt, M.; Urbaniak, T.; Nüssler, A. K. N.; Knobeloch, D.; Gerlach, J. C.; Zeilinger, K. (2008). Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology. Cytotechnology, 57(3), pp. 251–261. https://doi.org/10.1007/s10616-008-9168-6 Eckes, G. (2003). Six Sigma for Everyone, Hoboken, John Wiley & Sons, Inc. Farotti, E.; Natalini, M. (2018). Injection molding. Influence of process parameters on mechanical properties of polypropylene polymer. A first study. Procedia Structural Integrity, 8, pp. 256–264. https://doi.org/10.1016/j.prostr.2017.12.027 Gomes, F. P. C.; Thompson, M. R. (2018). Nondestructive evaluation of sintering and degradation for rotational molded polyethylene. Polymer Degradation and Stability, 157, pp. 34–43. https://doi.org/10.1016/j.polymdegradstab.2018.09.013 Gupta, S.; Uday, V.; Raghuwanshi, A. S.; Chowkshey, S.; Das, S. N.; Suresh, S. (2013). Simulation of Blow Molding Using Ansys Polyflow. APCBEE Procedia, 5, pp. 468–473. https://doi.org/10.1016/j.apcbee.2013.05.079 Jankovic, A.; Chaudhary, G.; Goia, F. (2021). Designing the design of experiments (DOE) – An investigation on the influence of different factorial designs on the characterization of complex systems. Energy and Buildings, 250, 111298. https://doi.org/10.1016/j.enbuild.2021.111298 Johnson, R.; Miller, I.; Freund, J. (2018). Miller & Freund’s probability and statistics for engineers, 9na ed., Madison, Pearson Education. Kumar, S.; Singh, R.; Singh, T. P.; Batish, A. (2019). On process capability comparison of hybrid and multi blend PLA matrix composite: Magnetic and surface properties viewpoint. Materials Today: Proceedings, 28, pp. 521–525. https://doi.org/10.1016/j.matpr.2019.12.212 Kwiatkowski, D.; Modławski, M.; Jaruga, T. (2017). Design of Flash Pocket Inserts in an Extrusion Blow Mould Based on the Results of Numerical Simulations. Procedia Engineering, 177, pp. 127–134. https://doi.org/10.1016/j.proeng.2017.02.200 Lee, B. C. Y.; Mahtab, M. S.; Neo, T. H.; Farooqi, I. H.; Khursheed, A. (2022). A comprehensive review of Design of experiment (DOE) for water and wastewater treatment application - Key concepts, methodology and contextualized application. Journal of Water Process Engineering, 47(December 2021), 102673. https://doi.org/10.1016/j.jwpe.2022.102673 Lewis, S. M.; De la Salle, B. (2008). Control de calidad, Dacie y Lewis, Hematología Práctica (10 ed.), pp. 561-572. https://doi.org/10.1016/b978-84-8086-229-5.50026-6 Lontos, A.; Gregoriou, A. (2019). The effect of the deformation rate on the wall thickness of 1.5LT PET bottle during ISBM (Injection Stretch Blow Molding) process. Procedia CIRP, 81, pp. 1307–1312. https://doi.org/10.1016/j.procir.2019.04.018 Machery, E. (2020). What is a Replication? Philosophy of Science, 87(4), pp. 545-567. https://doi.org/10.1086/709701. Montgomery, D. C. (2013). Design and Analysis of Experiments, 8va ed., Arizona State University, John Wiley & Sons. Nardi, D.; Sinke, J. (2021). Design analysis for thermoforming of thermoplastic composites: prediction and machine learning-based optimization. Composites Part C: Open Access, 5, 100126. https://doi.org/10.1016/j.jcomc.2021.100126 Nelles, O. (2020). Nonlinear System Identification. From Classical Approaches to Neural Networks, Fuzzy Models, and Gaussian Processes, Suiza, Springer: Cham. https://doi.org/10.1007/978-3-030-47439-3 Niedz, R. P.; Evens, T. J. (2016). Design of experiments (DOE)—history, concepts, and relevance to in vitro culture. In Vitro Cellular and Developmental Biology - Plant, 52(6), pp. 547–562. https://doi.org/10.1007/s11627-016-9786-1 Nieschlag, J.; Eisenhardt, P.; Coutandin, S.; Fleischer, J. (2021). Numerical design of rotationally molded composite tie rods. Composite Structures, 278, 114687. https://doi.org/10.1016/j.compstruct.2021.114687 Pakdil, F. (2020). Six Sigma for Students. A Problem-Solving Methodology, Suiza, Springer International Publishing. https://doi.org/10.1007/978-3-030-40709-4 Ramkumar, P. L.; Kulkarni, D. M.; Chaudhari, V. V. (2019). Fracture toughness of LLDPE parts using rotational moulding technology. 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