id	metarevistapublica_asoneumocito_revistacolombianadeneumologia_28_article_666
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spelling	Introduction: Inhaled therapy using a metered-dose inhaler (MDI) with attached valved holding chamber has been increasingly recognized as the optimal method for delivering bronchodilators for asthma treatment. However, mainly due to the high cost of these valved holding chambers, in Colombia the use of spacers without valves is frequent, despite the scarce evidence that supports its effectiveness. Objective: The aim of this study was to compare the bronchodilator response to albuterol administered by MDI with a valved holding chamber versus a commercially produced non-valved spacer. Design: A randomized, two-period, two-sequence crossover trial. Patients and methods: 31 patients were studied on two separate test days, and were randomly assigned to receive 100 and 400 mcg of salbutamol MDI either through a valved holding chamber or a non-valved spacer. Thereupon, crossover treatment was employed by the use of the alternative spacer in the same way. Spirometry was recorded before and after salbutamol administration. We evaluated sequence and period effects before testing for any treatment effect, using Student´s t test for independent samples, or the Mann-Whitney U test, as appropriate. Results: Since we identified no notable sequence or period effects, we tested for treatment effects in both periods. When patients received 100mcg of salbutamol, we found no statistically significant treatment differences in VEF1 (t=-0.42, p=0.68), CVF (t=-1.30, p=0.24) or MMEF (t=1.47, p=0.18). Likewise, when patients received 400mcg of salbutamol, we found no statistically significant treatment differences in VEF1 (t=-0.06, p=0.95), CVF (t=-1.28, p=0.24) or MMEF (t=1.16, p=0.28). Conclusions: The use of a valved spacer showed no advantage over the use of a non-valved spacer with respect to the bronchodilator response at different dosages of albuterol in stable asthmatic pediatric patients. Rodríguez Martínez, Carlos E. Sossa Briceño, Mónica P. Asthma Pediatrics Therapeutics Inhalation spacers cámaras espaciadoras administración inhalación asma 21 1 Artículo de revista Journal article 2009-04-14T00:00:00Z 2009-04-14T00:00:00Z 2009-04-14 application/pdf Asociación Colombiana de Neumología y Cirugía de Tórax Revista Colombiana de Neumología 0121-5426 2538-9513 https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/666 https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/666 spa https://creativecommons.org/licenses/by-nc-nd/4.0 Revista Colombiana de Neumología - 2023 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0. 2 13 https://revistas.asoneumocito.org/index.php/rcneumologia/article/download/666/546 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_2df8fbb1 http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication
institution	ASOCIACION COLOMBIANA DE NEUMOLOGIA Y CIRUGIA DE TORAX
thumbnail	https://nuevo.metarevistas.org/ASOCIACIONCOLOMBIANADENEUMOLOGIAYCIRUGIADETORAX/logo.png
country_str	Colombia
collection	Revista Colombiana de Neumología
description_eng	Introduction: Inhaled therapy using a metered-dose inhaler (MDI) with attached valved holding chamber has been increasingly recognized as the optimal method for delivering bronchodilators for asthma treatment. However, mainly due to the high cost of these valved holding chambers, in Colombia the use of spacers without valves is frequent, despite the scarce evidence that supports its effectiveness. Objective: The aim of this study was to compare the bronchodilator response to albuterol administered by MDI with a valved holding chamber versus a commercially produced non-valved spacer. Design: A randomized, two-period, two-sequence crossover trial. Patients and methods: 31 patients were studied on two separate test days, and were randomly assigned to receive 100 and 400 mcg of salbutamol MDI either through a valved holding chamber or a non-valved spacer. Thereupon, crossover treatment was employed by the use of the alternative spacer in the same way. Spirometry was recorded before and after salbutamol administration. We evaluated sequence and period effects before testing for any treatment effect, using Student´s t test for independent samples, or the Mann-Whitney U test, as appropriate. Results: Since we identified no notable sequence or period effects, we tested for treatment effects in both periods. When patients received 100mcg of salbutamol, we found no statistically significant treatment differences in VEF1 (t=-0.42, p=0.68), CVF (t=-1.30, p=0.24) or MMEF (t=1.47, p=0.18). Likewise, when patients received 400mcg of salbutamol, we found no statistically significant treatment differences in VEF1 (t=-0.06, p=0.95), CVF (t=-1.28, p=0.24) or MMEF (t=1.16, p=0.28). Conclusions: The use of a valved spacer showed no advantage over the use of a non-valved spacer with respect to the bronchodilator response at different dosages of albuterol in stable asthmatic pediatric patients.
author	Rodríguez Martínez, Carlos E. Sossa Briceño, Mónica P.
spellingShingle	Rodríguez Martínez, Carlos E. Sossa Briceño, Mónica P. Asthma Pediatrics Therapeutics Inhalation spacers cámaras espaciadoras administración inhalación asma
author_facet	Rodríguez Martínez, Carlos E. Sossa Briceño, Mónica P.
topic	Asthma Pediatrics Therapeutics Inhalation spacers cámaras espaciadoras administración inhalación asma
topic_facet	Asthma Pediatrics Therapeutics Inhalation spacers cámaras espaciadoras administración inhalación asma
topicspa_str_mv	cámaras espaciadoras administración inhalación asma
citationvolume	21
citationissue	1
publisher	Asociación Colombiana de Neumología y Cirugía de Tórax
ispartofjournal	Revista Colombiana de Neumología
source	https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/666
language	spa
format	Article
rights	https://creativecommons.org/licenses/by-nc-nd/4.0 Revista Colombiana de Neumología - 2023 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0. info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2
type_driver	info:eu-repo/semantics/article
type_coar	http://purl.org/coar/resource_type/c_6501
type_version	info:eu-repo/semantics/publishedVersion
type_coarversion	http://purl.org/coar/version/c_970fb48d4fbd8a85
type_content	Text
publishDate	2009-04-14
date_accessioned	2009-04-14T00:00:00Z
date_available	2009-04-14T00:00:00Z
url	https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/666
url_doi	https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/666
issn	0121-5426
eissn	2538-9513
citationstartpage	2
citationendpage	13
url2_str_mv	https://revistas.asoneumocito.org/index.php/rcneumologia/article/download/666/546
_version_	1811200732251029504

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