Titulo:
.
Guardado en:
0121-5426
2538-9513
34
2022-06-01
11
19
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
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metarevistapublica_asoneumocito_revistacolombianadeneumologia_28_article_558 |
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ojs |
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Introduction: COVID-19 has generated challenges due to the high demand for health care services, making it necessary to seek ventilatory support alternatives that allow us to fulfill the needs of the population. It is important to have tools that allow to detect the failure of non-invasive ventilatory strategies early and to identify the need for intubation on time. Objective: Identify the variables associated with failure of high-flow nasal cannula treatment (HFNC) on COVID-19 patients. Materials and Methods: Analytical observational, cross-sectional study of 68 patients in the intensive care unit with COVID-19, who received treatment with HFNC. The variables of the study were evaluated at three time points, at 24, 48 and 72 hours. A bivariate and multivariate analysis was performed between those who failed and those who were successful. Results: In the bivariate analysis, the variables that presented a statistically significant relationship at 24h were: No increase in work of breathing (WOB) (p=0.000), normal oxygen saturation (SatO2) (p=0.006). At 48h: No increase in WOB (p=0.014), normal SatO2 (p=0.005), mild to moderate partial pressure arterial oxygen/fraction inspired oxygen ratio (P/F ratio) (p=0.039). At 72h failed: severe P/F ratio (p=0.000), Increased WOB (p=0.001) and ROX index less than 4.88 (p=0.023). According to multivariate analysis the predictive variables for the therapeutic failure at 24h were: FIO2, SatO2, WOB; at 48h: FIO2 and SatO2. Conclusions: Increased FIO2>70%, increased WOB and SpO2 less than 88% are variables associated with failure of HFNC, and facilitate clinical decisions on whether or not to progress with invasive ventilatory support. Zúñiga Montenegro, Jubel David González Ramos, Daniela Catillo, John James León Giraldo, Hoover Arboleda, Harold COVID-19 noninvasive ventilation intensive care units Hypoxia Respiratory Insufficiency High-flow nasal cannula treatment HFNC COVID-19 ventilación no invasiva unidad de cuidados intensivos hipoxemia insuficiencia respiratoria Cánula Nasal de Alto Flujo CNAF 34 1 Artículo de revista Journal article 2022-06-01T00:00:00Z 2022-06-01T00:00:00Z 2022-06-01 application/pdf Asociación Colombiana de Neumología y Cirugía de Tórax Revista Colombiana de Neumología 0121-5426 2538-9513 https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/558 10.30789/rcneumologia.v34.n1.2022.558 https://doi.org/10.30789/rcneumologia.v34.n1.2022.558 spa https://creativecommons.org/licenses/by-nc-sa/4.0/ 11 19 https://revistas.asoneumocito.org/index.php/rcneumologia/article/download/558/506 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_2df8fbb1 http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication |
| institution |
ASOCIACION COLOMBIANA DE NEUMOLOGIA Y CIRUGIA DE TORAX |
| thumbnail |
https://nuevo.metarevistas.org/ASOCIACIONCOLOMBIANADENEUMOLOGIAYCIRUGIADETORAX/logo.png |
| country_str |
Colombia |
| collection |
Revista Colombiana de Neumología |
| description_eng |
Introduction: COVID-19 has generated challenges due to the high demand for health care services, making it necessary to seek ventilatory support alternatives that allow us to fulfill the needs of the population. It is important to have tools that allow to detect the failure of non-invasive ventilatory strategies early and to identify the need for intubation on time.
Objective: Identify the variables associated with failure of high-flow nasal cannula treatment (HFNC) on COVID-19 patients.
Materials and Methods: Analytical observational, cross-sectional study of 68 patients in the intensive care unit with COVID-19, who received treatment with HFNC. The variables of the study were evaluated at three time points, at 24, 48 and 72 hours. A bivariate and multivariate analysis was performed between those who failed and those who were successful.
Results: In the bivariate analysis, the variables that presented a statistically significant relationship at 24h were: No increase in work of breathing (WOB) (p=0.000), normal oxygen saturation (SatO2) (p=0.006). At 48h: No increase in WOB (p=0.014), normal SatO2 (p=0.005), mild to moderate partial pressure arterial oxygen/fraction inspired oxygen ratio (P/F ratio) (p=0.039). At 72h failed: severe P/F ratio (p=0.000), Increased WOB (p=0.001) and ROX index less than 4.88 (p=0.023). According to multivariate analysis the predictive variables for the therapeutic failure at 24h were: FIO2, SatO2, WOB; at 48h: FIO2 and SatO2.
Conclusions: Increased FIO2>70%, increased WOB and SpO2 less than 88% are variables associated with failure of HFNC, and facilitate clinical decisions on whether or not to progress with invasive ventilatory support.
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| author |
Zúñiga Montenegro, Jubel David González Ramos, Daniela Catillo, John James León Giraldo, Hoover Arboleda, Harold |
| spellingShingle |
Zúñiga Montenegro, Jubel David González Ramos, Daniela Catillo, John James León Giraldo, Hoover Arboleda, Harold COVID-19 noninvasive ventilation intensive care units Hypoxia Respiratory Insufficiency High-flow nasal cannula treatment HFNC COVID-19 ventilación no invasiva unidad de cuidados intensivos hipoxemia insuficiencia respiratoria Cánula Nasal de Alto Flujo CNAF |
| author_facet |
Zúñiga Montenegro, Jubel David González Ramos, Daniela Catillo, John James León Giraldo, Hoover Arboleda, Harold |
| topic |
COVID-19 noninvasive ventilation intensive care units Hypoxia Respiratory Insufficiency High-flow nasal cannula treatment HFNC COVID-19 ventilación no invasiva unidad de cuidados intensivos hipoxemia insuficiencia respiratoria Cánula Nasal de Alto Flujo CNAF |
| topic_facet |
COVID-19 noninvasive ventilation intensive care units Hypoxia Respiratory Insufficiency High-flow nasal cannula treatment HFNC COVID-19 ventilación no invasiva unidad de cuidados intensivos hipoxemia insuficiencia respiratoria Cánula Nasal de Alto Flujo CNAF |
| topicspa_str_mv |
COVID-19 ventilación no invasiva unidad de cuidados intensivos hipoxemia insuficiencia respiratoria Cánula Nasal de Alto Flujo CNAF |
| citationvolume |
34 |
| citationissue |
1 |
| publisher |
Asociación Colombiana de Neumología y Cirugía de Tórax |
| ispartofjournal |
Revista Colombiana de Neumología |
| source |
https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/558 |
| language |
spa |
| format |
Article |
| rights |
https://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
| type_driver |
info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_6501 |
| type_version |
info:eu-repo/semantics/publishedVersion |
| type_coarversion |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| type_content |
Text |
| publishDate |
2022-06-01 |
| date_accessioned |
2022-06-01T00:00:00Z |
| date_available |
2022-06-01T00:00:00Z |
| url |
https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/558 |
| url_doi |
https://doi.org/10.30789/rcneumologia.v34.n1.2022.558 |
| issn |
0121-5426 |
| eissn |
2538-9513 |
| doi |
10.30789/rcneumologia.v34.n1.2022.558 |
| citationstartpage |
11 |
| citationendpage |
19 |
| url2_str_mv |
https://revistas.asoneumocito.org/index.php/rcneumologia/article/download/558/506 |
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