Titulo:
.
Guardado en:
0121-5426
2538-9513
28
2017-07-09
78
93
Revista Colombiana de Neumología - 2017
info:eu-repo/semantics/openAccess
http://purl.org/coar/access_right/c_abf2
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Asthma is a multifactorial and complex desease, with different degrees of risks and severity, as well as the response to treatment. Medications currently available are mostly effective in severe asthma; nonetheless, there is a percentage of patients that have no response to the treatment that guidelines suggest in their recommendations. In the last years there has been researches in inflammatory molecules that contribute in asthma physiopathology and a lot of them have been considered to be possible targets in the management of severe asthma.As a consequence of this, a few monoclonal antibodies have been developed evidencing their effectiveness in the treatment of the disease. The study of these new therapies has allowed the identification of specific inflammatory pathways. This article pretends to offer a critical perspective of the current guidelines for the management of severe asthma, as well to discuss current treatments and the future in spot of the new molecular evidences. Through an adequate characterization, different phenotypes will be recognised and associated with a determinate biomarker, and should be used to select the treatment that can offer the highest effectiveness in this patients. In this way, the treatment will be directed to a personalized medicine. Silva E. MD., Diana L. Ramírez Z., MD., Luis Fernando Serrano R., MD., Carlos Daniel severe asthma monoclonal antibodies treatment phenotype endotype IL-4 IL-13 TSLP IL-5 biomarker asma grave guías de manejo anticuerpos monoclonales fenotipos endotipos interleucinas 4 5 13 linfoproteína tímica estromal biomarcadores 28 2 Artículo de revista Journal article 2017-07-09T16:31:56Z 2017-07-09T16:31:56Z 2017-07-09 application/pdf Asociación Colombiana de Neumología y Cirugía de Tórax Revista Colombiana de Neumología 0121-5426 2538-9513 https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/219 10.30789/rcneumologia.v28.n2.2016.219 https://doi.org/10.30789/rcneumologia.v28.n2.2016.219 spa https://creativecommons.org/licenses/by-nc-sa/4.0/ Revista Colombiana de Neumología - 2017 78 93 https://revistas.asoneumocito.org/index.php/rcneumologia/article/download/219/206 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_dcae04bc http://purl.org/redcol/resource_type/ARTREV info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication |
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ASOCIACION COLOMBIANA DE NEUMOLOGIA Y CIRUGIA DE TORAX |
| thumbnail |
https://nuevo.metarevistas.org/ASOCIACIONCOLOMBIANADENEUMOLOGIAYCIRUGIADETORAX/logo.png |
| country_str |
Colombia |
| collection |
Revista Colombiana de Neumología |
| description_eng |
Asthma is a multifactorial and complex desease, with different degrees of risks and severity, as well as the response to treatment. Medications currently available are mostly effective in severe asthma; nonetheless, there is a percentage of patients that have no response to the treatment that guidelines suggest in their recommendations. In the last years there has been researches in inflammatory molecules that contribute in asthma physiopathology and a lot of them have been considered to be possible targets in the management of severe asthma.As a consequence of this, a few monoclonal antibodies have been developed evidencing their effectiveness in the treatment of the disease. The study of these new therapies has allowed the identification of specific inflammatory pathways. This article pretends to offer a critical perspective of the current guidelines for the management of severe asthma, as well to discuss current treatments and the future in spot of the new molecular evidences. Through an adequate characterization, different phenotypes will be recognised and associated with a determinate biomarker, and should be used to select the treatment that can offer the highest effectiveness in this patients. In this way, the treatment will be directed to a personalized medicine.
|
| author |
Silva E. MD., Diana L. Ramírez Z., MD., Luis Fernando Serrano R., MD., Carlos Daniel |
| spellingShingle |
Silva E. MD., Diana L. Ramírez Z., MD., Luis Fernando Serrano R., MD., Carlos Daniel severe asthma monoclonal antibodies treatment phenotype endotype IL-4 IL-13 TSLP IL-5 biomarker asma grave guías de manejo anticuerpos monoclonales fenotipos endotipos interleucinas 4 linfoproteína tímica estromal biomarcadores |
| author_facet |
Silva E. MD., Diana L. Ramírez Z., MD., Luis Fernando Serrano R., MD., Carlos Daniel |
| topic |
severe asthma monoclonal antibodies treatment phenotype endotype IL-4 IL-13 TSLP IL-5 biomarker asma grave guías de manejo anticuerpos monoclonales fenotipos endotipos interleucinas 4 linfoproteína tímica estromal biomarcadores |
| topic_facet |
severe asthma monoclonal antibodies treatment phenotype endotype IL-4 IL-13 TSLP IL-5 biomarker asma grave guías de manejo anticuerpos monoclonales fenotipos endotipos interleucinas 4 linfoproteína tímica estromal biomarcadores |
| topicspa_str_mv |
asma grave guías de manejo anticuerpos monoclonales fenotipos endotipos interleucinas 4 linfoproteína tímica estromal biomarcadores |
| citationvolume |
28 |
| citationissue |
2 |
| publisher |
Asociación Colombiana de Neumología y Cirugía de Tórax |
| ispartofjournal |
Revista Colombiana de Neumología |
| source |
https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/219 |
| language |
spa |
| format |
Article |
| rights |
https://creativecommons.org/licenses/by-nc-sa/4.0/ Revista Colombiana de Neumología - 2017 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/article |
| type_coar |
http://purl.org/coar/resource_type/c_6501 |
| type_version |
info:eu-repo/semantics/publishedVersion |
| type_coarversion |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| type_content |
Text |
| publishDate |
2017-07-09 |
| date_accessioned |
2017-07-09T16:31:56Z |
| date_available |
2017-07-09T16:31:56Z |
| url |
https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/219 |
| url_doi |
https://doi.org/10.30789/rcneumologia.v28.n2.2016.219 |
| issn |
0121-5426 |
| eissn |
2538-9513 |
| doi |
10.30789/rcneumologia.v28.n2.2016.219 |
| citationstartpage |
78 |
| citationendpage |
93 |
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https://revistas.asoneumocito.org/index.php/rcneumologia/article/download/219/206 |
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