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spelling	Background: invasive fungal infections (IFI) are a major cause of mortality and morbidity worldwide. The increased incidence of these fungal infections are associated with an increase in immunosuppressive conditions.Objective: to describe demographic and clinical characteristics of immunosuppressed patients treated with antifungals for suspected invasive fungal infection (IFI) in a tertiary hospital.Materials and methods: in this descriptive cross-sectional study, immunosuppressed patients receiving antifungal treatment during 2012 and 2013, with suspected IFI (aspergillosis, cryptococcosis, mucormicosis and histoplasmosis) were included.Results: 81 patients, predominantly men (66.5%), with a mean age of 43.8 years were analyzed. The most common underlying conditions were lymphoproliferative disorders followed by HIV infection. Angioinvasive aspergillosis (52%) and cryptococcosis (28%) were most frequently suspected. 43% and 85% of patients had abnormal findings on chest radiograph and CT, respectively. 22% of the patients died and 17% required monitoring in the ICU and hemodynamic support. Conclusion: This highlights the importance of a high index of suspicion and early diagnosis of IFI, following an algorithm that enables the timely initiation of antifungal treatment to reduce fatal outcomes. It also identifies the obstacles of getting microbiological confirmation of these pathogens; the difficulties being similar in our institution to those reported elsewhere. Rey Sánchez, MD., Diana Bernal Vaca, MD., Laura Linares Linares, Bact., Melva Yomary Parra Giraldo, Bact., Claudia Marcela Garzón Erazo, MD., Javier Ricardo Valderrama Beltrán, MD., Sandra Liliana Cañas Arboleda, MD., Alejandra aspergillosis cryptococcosis histoplasmosis immunosuppressed invasive fungal infection aspergilosis criptococosis histoplasmosis inmunosuprimidos infección fúngica invasiva 28 1 Núm. 1 , Año 2016 : Revista Colombiana de Neumología Artículo de revista Journal article 2017-03-20T00:00:00Z 2017-03-20T00:00:00Z 2017-03-20 application/pdf Asociación Colombiana de Neumología y Cirugía de Tórax Revista Colombiana de Neumología 0121-5426 2538-9513 https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/159 10.30789/rcneumologia.v28.n1.2016.159 https://doi.org/10.30789/rcneumologia.v28.n1.2016.159 spa https://creativecommons.org/licenses/by-nc-sa/4.0/ Revista Colombiana de Neumología - 2017 10 16 https://revistas.asoneumocito.org/index.php/rcneumologia/article/download/159/150 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_2df8fbb1 http://purl.org/redcol/resource_type/ART info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication
institution	ASOCIACION COLOMBIANA DE NEUMOLOGIA Y CIRUGIA DE TORAX
thumbnail	https://nuevo.metarevistas.org/ASOCIACIONCOLOMBIANADENEUMOLOGIAYCIRUGIADETORAX/logo.png
country_str	Colombia
collection	Revista Colombiana de Neumología
description_eng	Background: invasive fungal infections (IFI) are a major cause of mortality and morbidity worldwide. The increased incidence of these fungal infections are associated with an increase in immunosuppressive conditions.Objective: to describe demographic and clinical characteristics of immunosuppressed patients treated with antifungals for suspected invasive fungal infection (IFI) in a tertiary hospital.Materials and methods: in this descriptive cross-sectional study, immunosuppressed patients receiving antifungal treatment during 2012 and 2013, with suspected IFI (aspergillosis, cryptococcosis, mucormicosis and histoplasmosis) were included.Results: 81 patients, predominantly men (66.5%), with a mean age of 43.8 years were analyzed. The most common underlying conditions were lymphoproliferative disorders followed by HIV infection. Angioinvasive aspergillosis (52%) and cryptococcosis (28%) were most frequently suspected. 43% and 85% of patients had abnormal findings on chest radiograph and CT, respectively. 22% of the patients died and 17% required monitoring in the ICU and hemodynamic support. Conclusion: This highlights the importance of a high index of suspicion and early diagnosis of IFI, following an algorithm that enables the timely initiation of antifungal treatment to reduce fatal outcomes. It also identifies the obstacles of getting microbiological confirmation of these pathogens; the difficulties being similar in our institution to those reported elsewhere.
author	Rey Sánchez, MD., Diana Bernal Vaca, MD., Laura Linares Linares, Bact., Melva Yomary Parra Giraldo, Bact., Claudia Marcela Garzón Erazo, MD., Javier Ricardo Valderrama Beltrán, MD., Sandra Liliana Cañas Arboleda, MD., Alejandra
spellingShingle	Rey Sánchez, MD., Diana Bernal Vaca, MD., Laura Linares Linares, Bact., Melva Yomary Parra Giraldo, Bact., Claudia Marcela Garzón Erazo, MD., Javier Ricardo Valderrama Beltrán, MD., Sandra Liliana Cañas Arboleda, MD., Alejandra aspergillosis cryptococcosis histoplasmosis immunosuppressed invasive fungal infection aspergilosis criptococosis histoplasmosis inmunosuprimidos infección fúngica invasiva
author_facet	Rey Sánchez, MD., Diana Bernal Vaca, MD., Laura Linares Linares, Bact., Melva Yomary Parra Giraldo, Bact., Claudia Marcela Garzón Erazo, MD., Javier Ricardo Valderrama Beltrán, MD., Sandra Liliana Cañas Arboleda, MD., Alejandra
topic	aspergillosis cryptococcosis histoplasmosis immunosuppressed invasive fungal infection aspergilosis criptococosis histoplasmosis inmunosuprimidos infección fúngica invasiva
topic_facet	aspergillosis cryptococcosis histoplasmosis immunosuppressed invasive fungal infection aspergilosis criptococosis histoplasmosis inmunosuprimidos infección fúngica invasiva
topicspa_str_mv	aspergilosis criptococosis histoplasmosis inmunosuprimidos infección fúngica invasiva
citationvolume	28
citationissue	1
citationedition	Núm. 1 , Año 2016 : Revista Colombiana de Neumología
publisher	Asociación Colombiana de Neumología y Cirugía de Tórax
ispartofjournal	Revista Colombiana de Neumología
source	https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/159
language	spa
format	Article
rights	https://creativecommons.org/licenses/by-nc-sa/4.0/ Revista Colombiana de Neumología - 2017 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2
type_driver	info:eu-repo/semantics/article
type_coar	http://purl.org/coar/resource_type/c_6501
type_version	info:eu-repo/semantics/publishedVersion
type_coarversion	http://purl.org/coar/version/c_970fb48d4fbd8a85
type_content	Text
publishDate	2017-03-20
date_accessioned	2017-03-20T00:00:00Z
date_available	2017-03-20T00:00:00Z
url	https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/159
url_doi	https://doi.org/10.30789/rcneumologia.v28.n1.2016.159
issn	0121-5426
eissn	2538-9513
doi	10.30789/rcneumologia.v28.n1.2016.159
citationstartpage	10
citationendpage	16
url2_str_mv	https://revistas.asoneumocito.org/index.php/rcneumologia/article/download/159/150
_version_	1811200699087716352

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