Titulo:
Hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura
.
Sumario:
El hemangioendotelioma epitelioide (HEE) es un tumor maligno posiblemente de origen vascular. Su localización usual es los tejidos blandos, mediastino, sistema nervioso central, pleura, pulmones, hígado y hueso. Sin embargo, es extremadamente rara su aparición en el corazón. Se presenta el caso de un paciente masculino de 67 años de edad, quien consulta por disnea progresiva, edema de miembros inferiores y hepatomegalia congestiva dolorosa. Se diagnóstica mediante biopsia HEE cardiaco primario. Posteriormente, se documenta recidiva tumoral, razón por la que fue evaluado por la junta médica de tumores que decidió iniciar quimioterapia (paclitaxel más doxorrubicina liposomal durante 6 ciclos). El paciente continúa en seguimiento por oncología... Ver más
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Revista Colombiana de Hematología y Oncología - 2022
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ASOCIACION COLOMBIANA DE HEMATOLOGIA Y ONCOLOGIA |
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Colombia |
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Revista Colombiana de Hematología y Oncología |
| title |
Hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura |
| spellingShingle |
Hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura Pantoja Rosero, María Elena Rivera-Martínez, Wilfredo Antonio Gómez-Gutiérrez, Rigoberto Santamaría, María Consuelo Mina Hinestroza, Miguel Ángel Portillo Miño, José Dario Hemangiosarcoma corazón quimioterapia adyuvante Epithelioid hemangioendothelioma neoplasms adjuvant chemotherapy |
| title_short |
Hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura |
| title_full |
Hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura |
| title_fullStr |
Hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura |
| title_full_unstemmed |
Hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura |
| title_sort |
hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura |
| title_eng |
Recurrent Primary Cardiac Hemangioendothelioma: Case Report and Literature Review |
| description |
El hemangioendotelioma epitelioide (HEE) es un tumor maligno posiblemente de origen vascular. Su localización usual es los tejidos blandos, mediastino, sistema nervioso central, pleura, pulmones, hígado y hueso. Sin embargo, es extremadamente rara su aparición en el corazón. Se presenta el caso de un paciente masculino de 67 años de edad, quien consulta por disnea progresiva, edema de miembros inferiores y hepatomegalia congestiva dolorosa. Se diagnóstica mediante biopsia HEE cardiaco primario. Posteriormente, se documenta recidiva tumoral, razón por la que fue evaluado por la junta médica de tumores que decidió iniciar quimioterapia (paclitaxel más doxorrubicina liposomal durante 6 ciclos). El paciente continúa en seguimiento por oncología con evidencia de enfermedad estable. El HEE cardiaco es un tumor muy raro. El tratamiento con paclitaxel más doxorrubicina es un esquema de quimioterapia que puede ser considerado en el manejo del HEE cardíaco primario avanzado o recurrente después de la cirugía cardíaca.
|
| description_eng |
Epithelioid hemangioendothelioma (EHE) is a malignant tumor possibly of vascular origin. Its usual location is the soft tissues, mediastinum, central nervous system, pleura, lungs, liver and bone. However, its appearance in the heart is extremely rare. We present the case of a 67-year-old male patient who consulted for progressive dyspnea, edema of the lower limbs and painful congestive hepatomegaly. Primary cardiac HEE is diagnosed by biopsy. Subsequently, tumor recurrence was documented, which is why the Tumor Board, which decided to start chemotherapy (Paclitaxel plus liposomal Doxorubicin for 6 cycles), evaluated him. The patient continues to be monitored by Oncology with evidence of stable disease. Primary cardiac HEE is a very rare tumor. Paclitaxel plus doxorubicin treatment is a chemotherapy regimen that may be considered in the management of advanced or recurrent primary cardiac HEE after cardiac surgery.
|
| author |
Pantoja Rosero, María Elena Rivera-Martínez, Wilfredo Antonio Gómez-Gutiérrez, Rigoberto Santamaría, María Consuelo Mina Hinestroza, Miguel Ángel Portillo Miño, José Dario |
| author_facet |
Pantoja Rosero, María Elena Rivera-Martínez, Wilfredo Antonio Gómez-Gutiérrez, Rigoberto Santamaría, María Consuelo Mina Hinestroza, Miguel Ángel Portillo Miño, José Dario |
| topicspa_str_mv |
Hemangiosarcoma corazón quimioterapia adyuvante |
| topic |
Hemangiosarcoma corazón quimioterapia adyuvante Epithelioid hemangioendothelioma neoplasms adjuvant chemotherapy |
| topic_facet |
Hemangiosarcoma corazón quimioterapia adyuvante Epithelioid hemangioendothelioma neoplasms adjuvant chemotherapy |
| citationvolume |
9 |
| citationissue |
2 |
| citationedition |
Núm. 2 , Año 2022 : Julio-diciembre |
| publisher |
Asociación Colombiana de Hematología y Oncología (ACHO) |
| ispartofjournal |
Revista Colombiana de Hematología y Oncología |
| source |
https://revista.acho.info/index.php/acho/article/view/403 |
| language |
spa |
| format |
Article |
| rights |
https://creativecommons.org/licenses/by-nc-nd/4.0 Revista Colombiana de Hematología y Oncología - 2022 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0. info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 |
| references |
Requena L, Kutzner H. Hemangioendothelioma. Semin Diagn Pathol [Internet]. 2013;30, 29-44. Disponible en: https:// doi.org/10.1053/j.semdp.2012.01.003 2. Rosenbaum E, Jadeja B, Xu B, Zhang L, Agaram NP, Travis W, Singer S, Tap WD, Antonescu CR. Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets. Mod Pathol [Internet]. 2020;33(4):591-602. Disponible en: https:// doi.org/10.1038/s41379-019-0368-8 3. Wu X, Li B, Zheng C, Hong T, He X. Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study. Eur J Med Res [Internet]. 2019;28;24(1):16. Disponible en: https://doi.org/10.1186/s40001-019-0375-8 4. Stacchiotti S, Frezza AM, Blay JY, et al. Ultra-rare sarcomas: a consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities. Cancer [Internet]. 2021;127(6):2934-2942. Disponible en: https://doi.org/10.1002/cncr.33618. 5. De Pinieux G, Karanian M, Le Loarer F, et al. Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network. PLoS One [Internet]. 2021;16:e0246958. Disponible en: https://doi.org/10.1371/journal.pone.0246958 6. Petrella F, Iacono GL, Monaco F, et al. Mediastinal aortopulmonary paraganglioma. Am Surg [Internet]. 2017;83:153-4. Disponible en: https://doi.org/10.1177/00031348170830050 7. Messias P, Bernardo J, Antunes MJ. Primary left atrial haemangioendothelioma. Thorac Surg [Internet]. 2008;7:9454-6. Disponible en: https://doi.org/10.1510/icvts.2008.184085 8. Leja MJ, Shah DJ, Reardon MJ. Primary cardiac tumors. Tex Heart Inst J [Internet]. 2011;38(3):261-262. PMCID: PMC3113129. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21720466/ 9. Huang W, Li L, Gao J, Gao JB. Epithelioid hemangioendothelioma of the right atrium invaded the superior vena cava: case report and review of literature. Int J Cardiovasc Imaging [Internet]. 2021;37(1):285-290. Disponible en: https://doi.org/doi:10.1007/s10554-020-01963-w 10. Petrella F, Bonalumi G, Andreini G, Camilli ED, Spaggiari L, and Alamanni F,. Primary Epithelioid Hemangioendothelioma of the Heart. Am Surg. 2018;84(6):199-200 11. Moidy MJ, Ibrahim OAM, Ali Khalifa EAI, Helmy SM. Right Atrial Pseudoaneurysm Complicating Epithelioid Hemangioendothelioma. Heart Views [Internet]. 2020;21(2):104-108. Disponible en: https://doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_96_19 12. Zhou X, Li P, Gu X, Zheng F, Zhao J, Zhao L. A case report of right atrial epithelioid hemangioendothelioma with multiple pulmonary metastases. Clin Respir J [Internet]. 2020;14(2):173-178. Disponible en: https://doi.org/10.1111/crj.13121 13. Ko JS, Billings SD. Diagnostically Challenging Epithelioid Vascular Tumors. Surg Pathol Clin [Internet]. 2015;8(3):331-51. Disponible en: https://doi.org/10.1016/j.path.2015.05.001 14. Antonescu, C. Malignant vascular tumors—an update. Mod Pathol [Internet]. 2014;27 (Suppl 1), 30-38. Disponible en: https://doi.org/10.1038/modpathol.2013.176 15. Deyrup AT, Tighiouart M, Montag AG, Weiss SW. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol [Internet]. 2008;32(6):924-7. Disponible en: https://doi.org/10.1097/pas.0b013e31815bf8e6 16. Antonescu et al. Novel YAP1-TFE3 Fusion Defines a Distinct Subset of Epithelioid Hemangioendothelioma. Genes Chromosomes Cancer [Internet]. 2013;52(8):775-784. Disponible en: https://doi.org/10.1002/gcc.22073 17. Suurmeijer AJH, Dickson BC, Swanson D, Sung YS, Zhang L, Antonescu CR, Suurmeijer et al. Variant WWTR1 gene fusions in epithelioid hemangioendothelioma—A genetic subset associated with cardiac involvement. Genes Chromosomes Cancer [Internet]. 2020;59:389-395. Disponible en: https://doi.org/10. 1002/gcc.22839 18. Stacchiotti S, Miah AB, Frezza AM, et al. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts. ESMO Open [Internet]. 2021;6(3):100170. Disponible en: https://doi.org/10.1016/j.esmoop.2021.100170 19. Errani C, Zhang L, Sung YS, et al. A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer [Internet]. 2011;50:644-653. Disponible en: https://doi.org/10.1002/gcc.20886 20. Safirstein J, Aksenov S, Smith F. Cardiac Epithelioid Hemangioendothelioma with 8-Year Follow up. Cardiovasc Pathol [Internet]. 2007;16(3)183-6. Disponible en: https://doi.org/10.1016/j.carpath.2006.10.003 21. Basso C, Rizzo S, Valente M, Thiene G. Prevalence and pathology of primary cardiac tumors. Cardiovasc Med. 2012;15(1):18-29. 22. Stiller B, Hetzer R, Meyer R, Dittrich S, Pees C,, Meskishvili VA. Primary cardiac tumours: when is surgery necessary? Eur J Cardiothorac Surg [Internet]. 2001;20:1002-6. Disponible en: https://doi.org/10.1016/s1010-7940(01)00951-4 23. Y. Epelboym, et al. Imaging findings in epithelioid hemangioendothelioma. Clin Imaging [Internet]. 2019;58:59-65. Disponible en: https://doi.org/10.1016/j.clinimag.2019.06.002 24. Flucke U, Vogels RJ, de Saint Aubain Somerhausen N, et al. Epithelioid hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol [Internet]. 2014;9:131. Disponible en: https://doi.org/10.1186/1746-1596-9-131 25. S. Arafa, and M. Sanad. Primary cardiac hemangioendothelioma of the mitral valve. Egypt Heart J [Internet]. 2018;70:229-232. Disponible en: https://doi.org/10.1016/j.ehj.2018.06.002 26. Sugimoto T, Yamamoto K, and Yoshii S. A Primary Epithelioid Hemangioendothelioma of the Right Atrium: Report of a Case and Literature Review. Open J Thorac Surg [Internet]. 2013;3:63-7. Disponible en: https://doi.org/10.4236/ojts.2013.32013 27. Stacchiotti S, Simeone N, Lo Vullo S, et al. Activity of sirolimus in patients with progressive epithelioid hemangioendothelioma: a case series analysis within the Italian rare cancer network. Cancer [Internet]. 2021;127:569-576. Disponible en: https://doi.org/10.1002/cncr.33247 28. Lau K, Massad M, Pollak C, et al. Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancer. Chest. 2011;140:1312-1318. 29. Frezza AM, Napolitano A, Miceli R, et al. Clinical prognostic factors in advanced epithelioid haemangioendothelioma: a retrospective series within the Italian Rare Cancers Network. ESMO Open [Internet]. 2021;6:100083. Disponible en: https://doi.org/10.1016/j.esmoop.2021.100083 30. Gaytán-Cortés FC et al. Hemangioendotelioma cardiaco primario: diagnóstico y resección quirúrgica temprana. Rev Med Inst Mex Seguro Soc [Internet]. 2016;54(3):392-6. Disponible en: https://www.medigraphic.com/pdfs/imss/im-2016/im163s.pdf 31. Angelini A, Mavrogenis AF, Gambarotti M, et al. Surgical treatment and results of 62 patients with epithelioid hemangioendothelioma of bone. J Surg Oncol [Internet]. 2014;109(8):791-7. Disponible en: https://doi.org/10.1002/jso.23587 32. Ishibashi H, Takasaki C, Akashi T, Okubo K. Successful excision of epithelioid hemangioendothelioma of the superior vena cava. Ann Thorac Surg [Internet]. 2019; Disponible en: https:// doi.org/10.1016/j.athoracsur.2019.07.027. 33. Allain et al. Surgical Management of an Epithelioid Hemangioendothelioma of the Superior Vena Cava Protruding into the Right Atrium. J Card Surg [Internet]. 2014;29:779-781. Disponible en: https://doi.org/10.1111/jocs.12370 34. Lee SS, Lee JH. Surgical treatment of asymptomatic epithelioid hemangioendothelioma originating from the superior vena cava: a case report. Medicine (Baltimore) [Internet]. 2020;99:16(e19859). Disponible en: http://dx.doi.org/10.1097/MD.0000000000019859 35. Abu Saleh WK, Ramlawi B, Shapira OM, Al Jabbari O, Ravi V, Benjamin R, et al. Improved outcomes with the evolution of a neoadjuvant chemotherapy approach to right heart sarcoma. Ann Thorac Surg [Internet]. 2017;104:90-6. Disponible en: https://doi.org/10.1016/j.athoracsur.2016.10.054 36. Yin K, Zhang Z, Luo R, Ji Y, Zheng D, Lin Y et al. Clinical features and surgical outcomes of pulmonary artery sarcoma. J Thorac Cardiovasc Surg [Internet]. 2018;155:1109-15. Disponible en: https://doi.org/10.1016/j.jtcvs.2017.10.101 37. Mentzel T, Beham A, Calonje E, Katenkamp D, Fletcher CD. Epithelioid hemangioendothelioma of skin and soft tissues: clinicopathologic and immunohistochemical study of 30 cases. Am J Surg Pathol [Internet]. 1997;21(4):363-74. Disponible en: https://doi.org/ 10.1097/00000478-199704000-00001 38. Lazarus A, Fuhrer G, Malekiani C, et al. Primary pleural epithelioid hemangioendothelioma (EHE)—two cases and review of the literature. Clin Respir J [Internet]. 2011;5(1):e1-5. Disponible en: https://doi.org/10.1111/j.1752-699X.2010.00221.x 39. Kim EA, Lele SM, Lackner RP. Primary pleural epithelioid hemangioendothelioma. Ann Thorac Surg [Internet]. 2011;91(1):301-2. Disponible en: https://doi.org/10.1016/j.athoracsur.2010.05.070 40. Zhang XQ, Chen H, Song S, Qin Y, Cai LM, Zhang F. Effective combined therapy for pulmonary epithelioid hemangioendothelioma: A case report. World J Clin Cases [Internet]. 2020;26;8(10):2009-2015. Disponible en: https://doi.org/10.12998/wjcc.v8.i10.2009 41. Din NU, Rahim S, Asghari T, Abdul-Ghafar J, Ahmad Z. Hepatic epithelioid hemangioendothelioma: case series of a rare vascular tumor mimicking metastases. Diagn Pathol [Internet]. 2020;25;15(1):120. Disponible en: https://doi.org/10.1186/s13000-020-01039-2 42. Ye B, Li W, Feng J, Shi J-X, Chen Y, Han B-H. Treatment of pulmonary epithelioid hemangioendothelioma with combination chemotherapy: Report of three cases and review of the literature. Oncol Lett [Internet]. 2013;5:1491-1496. Disponible en: https://doi.org/10.3892/ol.2013.1217 43. Zou, Z., Tao, T., Li, H. et al. mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges. Cell Biosci [Internet]. 2020;10(31):1-11. Disponible en: https://doi.org/10.1186/s13578-020-00396-1 44. Wan X, Helman LJ. The biology behind mTOR inhibition in sarcoma. Oncologist [Internet]. 2007;12(8):1007-1018. Disponible en: https://doi.org/10.1634/theoncologist.12-8-1007 45. Witte S, Weidema M, Kaal S, et al. The heterogeneity of Epithelioid Hemangioendothelioma (EHE): A case series and review of the literature with emphasis on treatment options. Semin Oncol [Internet]. 2021;48(2):111-118. Disponible en: https://doi.org/10.1053/j.seminoncol.2021.04.002 46. Semenisty V, Naroditsky I, Keidar Z, et al. Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma-a suitable treatment option: case report and review of anti-angiogenic treatment options. BMC Cancer [Internet]. 2015;15:402. Disponible en: https://doi.org/10.1186/s12885-015-1395-6 47. Kobayashi N, Shimamura T, Tokuhisa M, et al. Sorafenib monotherapy in a patient with unresectable hepatic epithelioid hemangioendothelioma. Case Rep Oncol [Internet]. 2016;9(1):134-7. Disponible en: https://doi.org/10.1159/000443986 48. Agulnik M, Yarber JL, Okuno SH, et al. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol [Internet]. 2013;24(1):257-63. Disponible en: https://doi.org/10.1093/annonc/mds237 49. Sangro B, Iñarrairaegui M, Fernández-Ros N. Malignant epithelioid hemangioendothelioma of the liver successfully treated with sorafenib. Rare Tumors [Internet]. 2012;4:106-109. Disponible en: https://doi.org/10.4081/rt.2012.e34 50. Stacher E, Gruber-Mösenbacher U, Halbwedl I, et al. The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: new potential therapeutic targets? Lung Cancer [Internet]. 2009;65:49-55. Disponible en: https://doi.org/10.1016/j.lungcan.2008.10.031 51. Chevreau C, Le Cesne A, Ray-Coquard I, Italiano A, Cioffi A, Isambert N et al. Sorafenib in patients with progressive epithelioid hemangioendothelioma: a phase 2 study by the French Sarcoma Group (GSF/GETO). Cancer [Internet]. 2013;119: 2639-2644. Disponible en: https://doi.org/10.1002/cncr.28109 52. Kyriazoglou A, Koutsoukos K, Zagouri F, et al. Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?. Ther Clin Risk Manag [Internet]. 2020;16:141-146. Disponible en: https://doi.org/10.2147/TCRM.S220804 53. Fukuhara S, Tahara H, Hirata Y, Ono K, Hamaoka M, Shimizu S, Hashimoto S, Kuroda S, Ohira M, Ide K, Kobayashi T, Ohdan H. Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review. Clin Case Rep [Internet]. 2019;17;8(1):108-115. Disponible en: https://doi.org/10.1002/ccr3.2558 54. Aksoy EA, Atalar B, Beylergil V, et al. Unresectable epithelioid hemangioendothelioma of the neck region cured by radiotherapy. J Med Cases [Internet]. 2011;2:147-150. Disponible en: https://doi.org/10.4021/jmc216w 55. Cottini M, Lappa A, Donfrancesco S. Primary cardiac hemangioendothelioma in the adult and cardiac involvement in patient with non-cardiac hemangioendothelioma. Review of literature. Cancer Stud Ther J [Internet]. 2017;2:1-6. Disponible en: https://doi.org/10.31038/CST.2017253 |
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Hemangioendotelioma cardiaco primario recurrente: reporte de caso y revisión de la literatura Recurrent Primary Cardiac Hemangioendothelioma: Case Report and Literature Review El hemangioendotelioma epitelioide (HEE) es un tumor maligno posiblemente de origen vascular. Su localización usual es los tejidos blandos, mediastino, sistema nervioso central, pleura, pulmones, hígado y hueso. Sin embargo, es extremadamente rara su aparición en el corazón. Se presenta el caso de un paciente masculino de 67 años de edad, quien consulta por disnea progresiva, edema de miembros inferiores y hepatomegalia congestiva dolorosa. Se diagnóstica mediante biopsia HEE cardiaco primario. Posteriormente, se documenta recidiva tumoral, razón por la que fue evaluado por la junta médica de tumores que decidió iniciar quimioterapia (paclitaxel más doxorrubicina liposomal durante 6 ciclos). El paciente continúa en seguimiento por oncología con evidencia de enfermedad estable. El HEE cardiaco es un tumor muy raro. El tratamiento con paclitaxel más doxorrubicina es un esquema de quimioterapia que puede ser considerado en el manejo del HEE cardíaco primario avanzado o recurrente después de la cirugía cardíaca. Epithelioid hemangioendothelioma (EHE) is a malignant tumor possibly of vascular origin. Its usual location is the soft tissues, mediastinum, central nervous system, pleura, lungs, liver and bone. However, its appearance in the heart is extremely rare. We present the case of a 67-year-old male patient who consulted for progressive dyspnea, edema of the lower limbs and painful congestive hepatomegaly. Primary cardiac HEE is diagnosed by biopsy. Subsequently, tumor recurrence was documented, which is why the Tumor Board, which decided to start chemotherapy (Paclitaxel plus liposomal Doxorubicin for 6 cycles), evaluated him. The patient continues to be monitored by Oncology with evidence of stable disease. Primary cardiac HEE is a very rare tumor. Paclitaxel plus doxorubicin treatment is a chemotherapy regimen that may be considered in the management of advanced or recurrent primary cardiac HEE after cardiac surgery. Pantoja Rosero, María Elena Rivera-Martínez, Wilfredo Antonio Gómez-Gutiérrez, Rigoberto Santamaría, María Consuelo Mina Hinestroza, Miguel Ángel Portillo Miño, José Dario Hemangiosarcoma corazón quimioterapia adyuvante Epithelioid hemangioendothelioma neoplasms adjuvant chemotherapy 9 2 Núm. 2 , Año 2022 : Julio-diciembre Artículo de revista Journal article 2023-02-20T00:00:00Z 2023-02-20T00:00:00Z 2023-02-20 application/pdf Asociación Colombiana de Hematología y Oncología (ACHO) Revista Colombiana de Hematología y Oncología 2256-2877 2256-2915 https://revista.acho.info/index.php/acho/article/view/403 10.51643/22562915.403 https://doi.org/10.51643/22562915.403 spa https://creativecommons.org/licenses/by-nc-nd/4.0 Revista Colombiana de Hematología y Oncología - 2022 Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0. Requena L, Kutzner H. Hemangioendothelioma. Semin Diagn Pathol [Internet]. 2013;30, 29-44. Disponible en: https:// doi.org/10.1053/j.semdp.2012.01.003 2. Rosenbaum E, Jadeja B, Xu B, Zhang L, Agaram NP, Travis W, Singer S, Tap WD, Antonescu CR. Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets. Mod Pathol [Internet]. 2020;33(4):591-602. Disponible en: https:// doi.org/10.1038/s41379-019-0368-8 3. Wu X, Li B, Zheng C, Hong T, He X. Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study. Eur J Med Res [Internet]. 2019;28;24(1):16. Disponible en: https://doi.org/10.1186/s40001-019-0375-8 4. Stacchiotti S, Frezza AM, Blay JY, et al. Ultra-rare sarcomas: a consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities. Cancer [Internet]. 2021;127(6):2934-2942. Disponible en: https://doi.org/10.1002/cncr.33618. 5. De Pinieux G, Karanian M, Le Loarer F, et al. Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network. PLoS One [Internet]. 2021;16:e0246958. Disponible en: https://doi.org/10.1371/journal.pone.0246958 6. Petrella F, Iacono GL, Monaco F, et al. Mediastinal aortopulmonary paraganglioma. Am Surg [Internet]. 2017;83:153-4. Disponible en: https://doi.org/10.1177/00031348170830050 7. Messias P, Bernardo J, Antunes MJ. Primary left atrial haemangioendothelioma. Thorac Surg [Internet]. 2008;7:9454-6. Disponible en: https://doi.org/10.1510/icvts.2008.184085 8. Leja MJ, Shah DJ, Reardon MJ. Primary cardiac tumors. Tex Heart Inst J [Internet]. 2011;38(3):261-262. PMCID: PMC3113129. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21720466/ 9. Huang W, Li L, Gao J, Gao JB. Epithelioid hemangioendothelioma of the right atrium invaded the superior vena cava: case report and review of literature. Int J Cardiovasc Imaging [Internet]. 2021;37(1):285-290. Disponible en: https://doi.org/doi:10.1007/s10554-020-01963-w 10. Petrella F, Bonalumi G, Andreini G, Camilli ED, Spaggiari L, and Alamanni F,. Primary Epithelioid Hemangioendothelioma of the Heart. Am Surg. 2018;84(6):199-200 11. Moidy MJ, Ibrahim OAM, Ali Khalifa EAI, Helmy SM. Right Atrial Pseudoaneurysm Complicating Epithelioid Hemangioendothelioma. Heart Views [Internet]. 2020;21(2):104-108. Disponible en: https://doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_96_19 12. Zhou X, Li P, Gu X, Zheng F, Zhao J, Zhao L. A case report of right atrial epithelioid hemangioendothelioma with multiple pulmonary metastases. Clin Respir J [Internet]. 2020;14(2):173-178. Disponible en: https://doi.org/10.1111/crj.13121 13. Ko JS, Billings SD. Diagnostically Challenging Epithelioid Vascular Tumors. Surg Pathol Clin [Internet]. 2015;8(3):331-51. Disponible en: https://doi.org/10.1016/j.path.2015.05.001 14. Antonescu, C. Malignant vascular tumors—an update. Mod Pathol [Internet]. 2014;27 (Suppl 1), 30-38. Disponible en: https://doi.org/10.1038/modpathol.2013.176 15. Deyrup AT, Tighiouart M, Montag AG, Weiss SW. Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. Am J Surg Pathol [Internet]. 2008;32(6):924-7. Disponible en: https://doi.org/10.1097/pas.0b013e31815bf8e6 16. Antonescu et al. Novel YAP1-TFE3 Fusion Defines a Distinct Subset of Epithelioid Hemangioendothelioma. Genes Chromosomes Cancer [Internet]. 2013;52(8):775-784. Disponible en: https://doi.org/10.1002/gcc.22073 17. Suurmeijer AJH, Dickson BC, Swanson D, Sung YS, Zhang L, Antonescu CR, Suurmeijer et al. Variant WWTR1 gene fusions in epithelioid hemangioendothelioma—A genetic subset associated with cardiac involvement. Genes Chromosomes Cancer [Internet]. 2020;59:389-395. Disponible en: https://doi.org/10. 1002/gcc.22839 18. Stacchiotti S, Miah AB, Frezza AM, et al. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts. ESMO Open [Internet]. 2021;6(3):100170. Disponible en: https://doi.org/10.1016/j.esmoop.2021.100170 19. Errani C, Zhang L, Sung YS, et al. A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosomes Cancer [Internet]. 2011;50:644-653. Disponible en: https://doi.org/10.1002/gcc.20886 20. Safirstein J, Aksenov S, Smith F. Cardiac Epithelioid Hemangioendothelioma with 8-Year Follow up. Cardiovasc Pathol [Internet]. 2007;16(3)183-6. Disponible en: https://doi.org/10.1016/j.carpath.2006.10.003 21. Basso C, Rizzo S, Valente M, Thiene G. Prevalence and pathology of primary cardiac tumors. Cardiovasc Med. 2012;15(1):18-29. 22. Stiller B, Hetzer R, Meyer R, Dittrich S, Pees C,, Meskishvili VA. Primary cardiac tumours: when is surgery necessary? Eur J Cardiothorac Surg [Internet]. 2001;20:1002-6. Disponible en: https://doi.org/10.1016/s1010-7940(01)00951-4 23. Y. Epelboym, et al. Imaging findings in epithelioid hemangioendothelioma. Clin Imaging [Internet]. 2019;58:59-65. Disponible en: https://doi.org/10.1016/j.clinimag.2019.06.002 24. Flucke U, Vogels RJ, de Saint Aubain Somerhausen N, et al. Epithelioid hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol [Internet]. 2014;9:131. Disponible en: https://doi.org/10.1186/1746-1596-9-131 25. S. Arafa, and M. Sanad. Primary cardiac hemangioendothelioma of the mitral valve. Egypt Heart J [Internet]. 2018;70:229-232. Disponible en: https://doi.org/10.1016/j.ehj.2018.06.002 26. Sugimoto T, Yamamoto K, and Yoshii S. A Primary Epithelioid Hemangioendothelioma of the Right Atrium: Report of a Case and Literature Review. Open J Thorac Surg [Internet]. 2013;3:63-7. Disponible en: https://doi.org/10.4236/ojts.2013.32013 27. Stacchiotti S, Simeone N, Lo Vullo S, et al. Activity of sirolimus in patients with progressive epithelioid hemangioendothelioma: a case series analysis within the Italian rare cancer network. Cancer [Internet]. 2021;127:569-576. Disponible en: https://doi.org/10.1002/cncr.33247 28. Lau K, Massad M, Pollak C, et al. Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancer. Chest. 2011;140:1312-1318. 29. Frezza AM, Napolitano A, Miceli R, et al. Clinical prognostic factors in advanced epithelioid haemangioendothelioma: a retrospective series within the Italian Rare Cancers Network. ESMO Open [Internet]. 2021;6:100083. Disponible en: https://doi.org/10.1016/j.esmoop.2021.100083 30. Gaytán-Cortés FC et al. Hemangioendotelioma cardiaco primario: diagnóstico y resección quirúrgica temprana. Rev Med Inst Mex Seguro Soc [Internet]. 2016;54(3):392-6. Disponible en: https://www.medigraphic.com/pdfs/imss/im-2016/im163s.pdf 31. Angelini A, Mavrogenis AF, Gambarotti M, et al. Surgical treatment and results of 62 patients with epithelioid hemangioendothelioma of bone. J Surg Oncol [Internet]. 2014;109(8):791-7. Disponible en: https://doi.org/10.1002/jso.23587 32. Ishibashi H, Takasaki C, Akashi T, Okubo K. Successful excision of epithelioid hemangioendothelioma of the superior vena cava. Ann Thorac Surg [Internet]. 2019; Disponible en: https:// doi.org/10.1016/j.athoracsur.2019.07.027. 33. Allain et al. Surgical Management of an Epithelioid Hemangioendothelioma of the Superior Vena Cava Protruding into the Right Atrium. J Card Surg [Internet]. 2014;29:779-781. Disponible en: https://doi.org/10.1111/jocs.12370 34. Lee SS, Lee JH. Surgical treatment of asymptomatic epithelioid hemangioendothelioma originating from the superior vena cava: a case report. Medicine (Baltimore) [Internet]. 2020;99:16(e19859). Disponible en: http://dx.doi.org/10.1097/MD.0000000000019859 35. Abu Saleh WK, Ramlawi B, Shapira OM, Al Jabbari O, Ravi V, Benjamin R, et al. Improved outcomes with the evolution of a neoadjuvant chemotherapy approach to right heart sarcoma. Ann Thorac Surg [Internet]. 2017;104:90-6. Disponible en: https://doi.org/10.1016/j.athoracsur.2016.10.054 36. Yin K, Zhang Z, Luo R, Ji Y, Zheng D, Lin Y et al. Clinical features and surgical outcomes of pulmonary artery sarcoma. J Thorac Cardiovasc Surg [Internet]. 2018;155:1109-15. Disponible en: https://doi.org/10.1016/j.jtcvs.2017.10.101 37. Mentzel T, Beham A, Calonje E, Katenkamp D, Fletcher CD. Epithelioid hemangioendothelioma of skin and soft tissues: clinicopathologic and immunohistochemical study of 30 cases. Am J Surg Pathol [Internet]. 1997;21(4):363-74. Disponible en: https://doi.org/ 10.1097/00000478-199704000-00001 38. Lazarus A, Fuhrer G, Malekiani C, et al. Primary pleural epithelioid hemangioendothelioma (EHE)—two cases and review of the literature. Clin Respir J [Internet]. 2011;5(1):e1-5. Disponible en: https://doi.org/10.1111/j.1752-699X.2010.00221.x 39. Kim EA, Lele SM, Lackner RP. Primary pleural epithelioid hemangioendothelioma. Ann Thorac Surg [Internet]. 2011;91(1):301-2. Disponible en: https://doi.org/10.1016/j.athoracsur.2010.05.070 40. Zhang XQ, Chen H, Song S, Qin Y, Cai LM, Zhang F. Effective combined therapy for pulmonary epithelioid hemangioendothelioma: A case report. World J Clin Cases [Internet]. 2020;26;8(10):2009-2015. Disponible en: https://doi.org/10.12998/wjcc.v8.i10.2009 41. Din NU, Rahim S, Asghari T, Abdul-Ghafar J, Ahmad Z. Hepatic epithelioid hemangioendothelioma: case series of a rare vascular tumor mimicking metastases. Diagn Pathol [Internet]. 2020;25;15(1):120. Disponible en: https://doi.org/10.1186/s13000-020-01039-2 42. Ye B, Li W, Feng J, Shi J-X, Chen Y, Han B-H. Treatment of pulmonary epithelioid hemangioendothelioma with combination chemotherapy: Report of three cases and review of the literature. Oncol Lett [Internet]. 2013;5:1491-1496. Disponible en: https://doi.org/10.3892/ol.2013.1217 43. Zou, Z., Tao, T., Li, H. et al. mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges. Cell Biosci [Internet]. 2020;10(31):1-11. Disponible en: https://doi.org/10.1186/s13578-020-00396-1 44. Wan X, Helman LJ. The biology behind mTOR inhibition in sarcoma. Oncologist [Internet]. 2007;12(8):1007-1018. Disponible en: https://doi.org/10.1634/theoncologist.12-8-1007 45. Witte S, Weidema M, Kaal S, et al. The heterogeneity of Epithelioid Hemangioendothelioma (EHE): A case series and review of the literature with emphasis on treatment options. Semin Oncol [Internet]. 2021;48(2):111-118. Disponible en: https://doi.org/10.1053/j.seminoncol.2021.04.002 46. Semenisty V, Naroditsky I, Keidar Z, et al. Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma-a suitable treatment option: case report and review of anti-angiogenic treatment options. BMC Cancer [Internet]. 2015;15:402. Disponible en: https://doi.org/10.1186/s12885-015-1395-6 47. Kobayashi N, Shimamura T, Tokuhisa M, et al. Sorafenib monotherapy in a patient with unresectable hepatic epithelioid hemangioendothelioma. Case Rep Oncol [Internet]. 2016;9(1):134-7. Disponible en: https://doi.org/10.1159/000443986 48. Agulnik M, Yarber JL, Okuno SH, et al. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol [Internet]. 2013;24(1):257-63. Disponible en: https://doi.org/10.1093/annonc/mds237 49. Sangro B, Iñarrairaegui M, Fernández-Ros N. Malignant epithelioid hemangioendothelioma of the liver successfully treated with sorafenib. Rare Tumors [Internet]. 2012;4:106-109. Disponible en: https://doi.org/10.4081/rt.2012.e34 50. Stacher E, Gruber-Mösenbacher U, Halbwedl I, et al. The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: new potential therapeutic targets? Lung Cancer [Internet]. 2009;65:49-55. Disponible en: https://doi.org/10.1016/j.lungcan.2008.10.031 51. Chevreau C, Le Cesne A, Ray-Coquard I, Italiano A, Cioffi A, Isambert N et al. Sorafenib in patients with progressive epithelioid hemangioendothelioma: a phase 2 study by the French Sarcoma Group (GSF/GETO). Cancer [Internet]. 2013;119: 2639-2644. Disponible en: https://doi.org/10.1002/cncr.28109 52. Kyriazoglou A, Koutsoukos K, Zagouri F, et al. Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?. Ther Clin Risk Manag [Internet]. 2020;16:141-146. Disponible en: https://doi.org/10.2147/TCRM.S220804 53. Fukuhara S, Tahara H, Hirata Y, Ono K, Hamaoka M, Shimizu S, Hashimoto S, Kuroda S, Ohira M, Ide K, Kobayashi T, Ohdan H. Hepatic epithelioid hemangioendothelioma successfully treated with living donor liver transplantation: A case report and literature review. Clin Case Rep [Internet]. 2019;17;8(1):108-115. Disponible en: https://doi.org/10.1002/ccr3.2558 54. Aksoy EA, Atalar B, Beylergil V, et al. Unresectable epithelioid hemangioendothelioma of the neck region cured by radiotherapy. J Med Cases [Internet]. 2011;2:147-150. Disponible en: https://doi.org/10.4021/jmc216w 55. Cottini M, Lappa A, Donfrancesco S. Primary cardiac hemangioendothelioma in the adult and cardiac involvement in patient with non-cardiac hemangioendothelioma. Review of literature. Cancer Stud Ther J [Internet]. 2017;2:1-6. Disponible en: https://doi.org/10.31038/CST.2017253 https://revista.acho.info/index.php/acho/article/download/403/469 info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 http://purl.org/redcol/resource_type/ARTREF info:eu-repo/semantics/publishedVersion http://purl.org/coar/version/c_970fb48d4fbd8a85 info:eu-repo/semantics/openAccess http://purl.org/coar/access_right/c_abf2 Text Publication |